C. Yang, F.W. DelRio, H. Ma, A.R. Killaars, L.P. Basta, K.A. Kyburz, and K.S. Anseth, "Spatially patterned matrix elasticity directs stem cell fate," Proc. Natl. Acad. Sci. U.S.A, 2016, 113(31), E4439-E4445.

K.M. Mabry, M.E. Schroeder, S.Z. Payne, K.S. Anseth, "Three-Dimensional High-Throughput Cell Encapsulation Platform to Study Changes in Cell-Matrix Interactions", ACS applied materials & interfaces, 2016.

C.M Magin, D.L. Alge, K.S Anseth, "Bio-inspired 3D microenvironments: a new dimension in tissue engineering", Biomedical Materials, 11, 2, 022001.

A.M. Rosales and K.S. Anseth, "The design of reversible hydrogels to capture extracellular matrix dynamics," Nature Reviews Materials, 2016, 1, 15012.

K.M. Mabry, S.Z. Payne, and K.S. Anseth, "Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype," Biomaterials, 2016, 74, 31-41.

E.M. Nehls, A.M. Rosales, and K.S. Anseth, "Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel viaazobenzene/cyclodextrin complex tethers" Journal of Materials Chemistry B, 2016, 4, 1035-1039

M.A. Azagarsamy, I.A. Marozas, S. Spaans, and K.S. Anseth "Photoregulated Hydrazone-Based Hydrogel Formation for Biochemically Patterning 3D Cellular Microenvironments," ACS Macro Letters, 2016, 5, 19-23.


B.V. Sridhar, E.A. Dailing, J.L. Brock, J.W. Stansbury, M.A. Randolph, K.S. Anseth "A Biosynthetic Scaffold that Facilitates Chondrocyte-Mediated Degradation and Promotes Articular Cartilage Extracellular Matrix Deposition," Regenerative Engineering and Translational Medicine 2015, 1, 1-11. 

J.C. Grim, I.A. Marozas, and K.S. Anseth "Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels," Journal of Controlled Release 2015.

J.L. Leight, E.Y. Tokuda, C.E. Jones, A.J. Lin, and K.S. Anseth "Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition," Proceedings of the National Academy of Sciences 2015, 112(17), 5366-5371.

K.J.R. Lewis, M.W. Tibbitt, Y. Zhao, K. Branchfield, X. Sun, V. Balasubramanian, and K.S. Anseth, "In vitro model alveoli from photodegradable microsphere templates," Biomaterials Science 2015, 3, 821-832.

K.M. Mabry, R.L. Lawrence, and K.S. Anseth, "Dynamic stiffening of poly (ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment," Biomaterials 2015, 49, 47-56.

K.A. Kyburz and K.S. Anseth, "Synthetic Mimics of the Extracellular Matrix: How Simple is Complex Enough?," Annals of Biomedical Engineering 2015, 43(3), 489-500.

A.M. Rosales, K.M. Mabry, E.M. Nehls, and K.S. Anseth, "Photoresponsive Elastic Properties of Azobenzene-Containing Poly(ethylene-glycol)-based Hydrogels." Biomacromolecules 2015, 16(3), 798-806.

B.V. Sridhar, J.L. Brock, J.S. Silver, J.L. Leight, M.A. Randolph, and K.S. Anseth, "Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition," Advanced Healthcare Materials 2015, 4(5), 635-781.


B.V. Sridhar, N.R. Doyle, M.A. Randolph, and K.S. Anseth, "Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production," Journal of Biomedical Materials Research (2014).

H. Wang, L.A. Leinwand, and K.S. Anseth, "Cardiac valve cells and their microenvironment—insights from in vitro studies," Nature Reviews Cardiology (2014).

D.D. McKinnon, D.W. Domaille, T.E. Brown, K.A. Kyburz, E. Kiyotake, J.N. Cha, and K.S. Anseth, "Measuring cellular forces using bis-aliphatic hydrazone crosslinked stress-relaxing hydrogels," Soft Matter (2014).

H. Wang, L.A. Leinwand, and K.S. Anseth, "Roles of transforming growth factor-1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation," FASEB J (2014).

D.D. McKinnon, T.E. Brown, K.A. Kyburz, E. Kiyotake, and K.S. Anseth, "Design and Characterization of a Synthetically Accessible, Photodegradable Hydrogel for User-Directed Formation of Neural Networks," Biomacromolecules (2014).

M.A. Azagarsamy, D.D. McKinnon, D.L. Alge, and K.S. Anseth, "Coumarin-Based Photodegradable Hydrogel: Design, Synthesis, Gelation, and Degradation Kinetics," ACS Macro Letters (2014).

S.P. Singh, M.P. Schwartz, J.Y. Lee, B.D. Fairbanks, and K.S. Anseth, "A Peptide Functionalized Poly(ethylene glycol) (PEG) Hydrogel for Investigating the Influence of Biochemical and Biophysical Matrix Properties on Tumor Cell Migration," Biomaterials Science (2014).

D.D. McKinnon, D.W. Domaille, J.N. Cha, and K.S. Anseth, "Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies," Chemistry of Materials (2014).

C. Yang, M.W. Tibbitt, L. Basta, and K.S. Anseth, "Mechanical memory and dosing influence stem cell fate," Nature Materials (2014).

E.Y. Tokuda, J.L. Leight, and K.S. Anseth, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness," Biomaterials (2014).

N.R. Gandavarapu, M.A. Azagarsamy, and K.S. Anseth, "Photo-Click Living Strategy for Controlled, Reversible Exchange of Biochemical Ligands," Advanced Materials (2014).

C.M. Kirschner, D.L. Alge, S.T. Gould, and K.S. Anseth, "Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype," Advanced Healthcare Materials (2014).

S.T. Gould, E.E. Matherly, J.N. Smith, D.D. Heistad, and K.S. Anseth, "The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation," Biomaterials (2014).


S.T. Gould and K.S. Anseth, "Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels," Journal of Tissue Engineering and Regenerative Medicine (2013).

A.B. Bernard, R.Z. Chapman, and K.S. Anseth, "Controlled local presentation of matrix proteins in microparticle-laden cell aggregates," Biotechnology and Bioengineering (2013).

E.S. Witze, M.K. Connacher, S. Houel, M.P. Schwartz, M.K. Morphew, L. Reid, D.B. Sacks, K.S. Anseth, and N.G. Ahn, "Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge," Developmental Cell, 26 (6), 645-6657 (2013).

M.P. Schwartz, R.R. Rogers, S.P. Singh, J.Y. Lee, S.G. Loveland, J.T. Koepsel, E.S. Witze, S.I. Montanez-Sauri, K.E. Sung, E.Y. Tokuda, Y. Sharma, L.M. Everhart, E.H. Nguyen, M.H. Zaman, D.J. Beebe, N.G. Ahn, W.L. Murphy, and K.S. Anseth, "A Quantitative Comparison of Human HT-1080 Fibrosarcoma Cells and Primary Human Dermal Fibroblasts Identifies a 3D Migration Mechanism with Properties Unique to the Transformed Phenotype," PLoS ONE (2013).

N.R. Gandavarapu, D.L. Alge and K.S. Anseth, "Osteogenic differentiation of human mesenchymal stem cells on α5 integrin binding peptide hydrogels is dependent on substrate elasticity," Biomaterials Science (2013).

D.L. Alge and K.S. Anseth, "Bioactive Hydrogels: Lighting the Way," Nature Materials (2013).

H. Wang, M.W. Tibbitt, S.J. Langer, L.A. Leinwand, and K.S. Anseth, "Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway," Proceedings of the National Academy of Sciences (2013).

M.A. Azagarsamy and K.S. Anseth, "Wavelength-Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins," Angewandte Chemie (2013).

D.D. McKinnon, D.W. Domaille, J.N. Cha, and K.S. Anseth, "Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems," Advanced Materials (2013).

D.L. Alge, D.F. Donohue, and K.S. Anseth, "Facile and Efficient Lewis Acid Catalyzed Synthesis of an Asymmetric Tetrazine Useful for Bio-Orthogonal Click Chemistry Applications," Tetrahedron Letters (2013).

H. Wang, B. Sridhar, L.A. Leinwand, and K.S. Anseth, "Characterization of Cell Subpopulations Expressing Progenitor Cell Markers in Porcine Cardiac Valves," PLoS ONE 8(7): e69667 (2013).

J.L. Leight, D.L. Alge, A.J. Maier, and K.S. Anseth, "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate," Biomaterials (2013).

S.T. Gould, S. Srigunapalan, C.A. Simmons, and K.S. Anseth, "Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease," Circulation Research (2013).

K.C. Koehler, D.L. Alge, K.S. Anseth, and C.N. Bowman, "Development of a Novel Maleimide Amino Acid for Use as a Tool for Peptide Conjugation and Modification," International Journal of Peptide Research and Therapeutics (2013).

M.W. Tibbitt, A.M. Kloxin, L.A. Sawicki, and K.S. Anseth, "Mechanical Properties and Degradation of Chain and Step-Polymerized Photodegradable Hydrogels," Macromolecules, 46 (7), 2785-2792 (2013).

K.J.R. Lewis and K.S. Anseth, "Hydrogel Scaffolds to Study Cell Biology in Four Dimensions," MRS Bulletin, 38 (3), 260-268 (2013).

D.A. Alge, M.A. Azagarsamy, D.F. Donohue, and K.S. Anseth, "Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry," Biomacromolecules (2013).

M.W. Tibbitt, A.M. Kloxin, and K.S. Anseth, "Modeling Controlled Photodegradation in Optically Thick Hydrogels," Journal of Polymer Science Part A: Polymer Chemistry (2013).

J-L. Ruan, N.L. Tulloch, V. Muskheli, E.E. Genova, P.D. Mariner, K.S. Anseth, and C.E. Murry, "An Improved Cryosection Method for Polyethylene Glycol Hydrogels Used in Tissue Engineering," Tissue Engineering Part C: Methods (2013).

K.C. Koehler, D.A. Alge, K.S. Anseth, and C.N. Bowman, "A Diels-Alder Modulated Approach to Control and Sustain the Release of Dexamethasone and Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells," Biomaterials (2013).

K.C. Koehler, K.S. Anseth, and C.N. Bowman, "Diels–Alder Mediated Controlled Release from a Poly(ethylene glycol) Based Hydrogel," Biomacromolecules, 14 (2), 538-547 (2013).

K.A. Kyburz and K.S. Anseth, "Three-Dimensional hMSC Motility within Peptide-Functionalized PEG-Based Hydrogels of Varying Adhesivity and Crosslinking Density," Acta Biomaterialia (2013).

D.D. McKinnon, A.M Kloxin, and K.S. Anseth, "Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons," Biomaterials Science, 1 (5), 460-469 (2013).

C.M. Kirschner and K.S. Anseth, " Hydrogels in Healthcare: From Static to Dynamic Material Microenvironments," Acta Materialia, 61, 931-944 (2013).

M.A. Azagarsamy and K.S. Anseth, "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds," ACS Macro Letters, 2, 5-9 (2013)

K.M. Schultz and K.S. Anseth, "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle Tracking Microrheology," Soft Matter, 9 (5), 1570-1579 (2013).

R. Shenvoy, M.W. Tibbitt, K.S. Anseth, and C.N. Bowman, "Formation of Core-Shell Particles by Interfacial Radical Polymerization Initiated by a Glucose Oxidase-Mediated Redox System," Chemistry of Materials, 25 (5), 761-767 (2013).

P.D. Mariner, J.M. Wudel, D.E. Miller, E.E. Genova, S.O. Streubel, and K.S. Anseth, "Synthetic Hydrogel Scaffold is an Effective Vehicle for Delivery of INFUSE (rhBMP2) to Critical-Sized Calvaria Bone Defects in Rats," Journal of Orthopaedic Research, 31 (3), 401-406 (2012).

C.M. Kirschner and K.S. Anseth, "In Situ Control of Cell Substrate Microtopographies Using Photolabile Hydrogels," Small, 9 (4), 578-584 (2012).

N.R. Gandavarapu, P.D. Mariner, M.P. Schwartz, and K.S. Anseth, "Extracellular Matrix Protein Adsorption to Phosphate-Functionalized Gels from Serum Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells," Acta Biomaterialia, 9 (1), 4525-4534 (2013).


B.J. Adzima, C.J. Kloxin, C.A. DeForest, K.S. Anseth, and C.N. Bowman, "3D Photofixation Lithography in Diels-Alder Networks," Macromolecular Rapid Comminications, 33, 2092-2096 (2012).

C. Yang, P.D. Mariner, J.N. Nahreini, and K.S. Anseth, "Cell-Mediated Delivery of Glutocorticoids from Thiol-Ene Hydrogels," Journal of Controlled Release, 162, 612-618 (2012).

J.D. McCall, J.E. Luoma, and K.S Anseth, "Covalently Tethered Transforming Growth Factor Beta in PEG Hydrogels Promotes Chondrogenic Differentiation of Encapsulated Human Mesenchymal Stem Cells," Drug Delivery and Translation Research, 2 (5), 305-312 (2012).

M.W. Tibbitt and K.S. Anseth, "Dynamic Microenvironments: The Fourth Dimension," Science Translational Medicine, 4, 160ps24 (2012).

A.M. Kloxin, K.J.R. Lewis, C.A. DeForest, G. Seedorf, M.W. Tibbitt, V. Balasubramaniam, and K.S. Anseth, "Responsive Culture Platform to Examine the Influence of Microgeometry on Cell Function in 3D," Integrative Biology, 4 (12), 1540-1549 (2012).

Q.Y. Guo, X.B. Wang, M.W. Tibbitt, K.S. Anseth, D.J. Montell, and J.H. Elisseef, "Light Activated Cell Migration in Synthetic Extracellular Matrices," Biomaterials, 33 (32), 8040-8046 (2012).

C.A. DeForest and K.S. Anseth, "Bioactive Hydrogels for Regenerative Medicine," Annual Review of Chemical and Biomolecular Engineering, 3, 421-444 (2012).

S. Pedron, X. Peinado, F. Catalina, P. Bosch, K.S. Anseth, and C. Abrusci, "Combinatorial Approach for Fabrication of Coatings to Control Bacterial Adhesion," Journal of Biomaterials Science-Polymer Edition, 23 (12), 1613-1628 (2012).

A.B. Bernard, C.C. Lin, and K.S. Anseth, "A Microwell Culture Platform for the Aggregation of Pancreatic Beta-Cells," Tissue Engineering Part C-Methods, 18 (8), 583-592 (2012).

J.D. McCall and K.S. Anseth, "Thiol-Ene Photopolymerizations Provide a Facile Method to Encapsulate Proteins and Maintain their Bioactivity," Biomacromolecules, 13 (8), 2410-2417 (2012).

S.T. Gould, N.J. Darling, and K.S. Anseth, “Small Peptide Functionalized Thiol-Ene Hydrogels as Culture Substrates for Understanding Valvular Interstitial Cell Activation and de novo Tissue Deposition,” Acta Biomaterialia, 8 (9), 3201-3209 (2012).

M.A. Azagarsamy, N.R. Gandavarappu, and K.S. Anseth, "Versatile Cell Culture Scaffolds Via Bio-Orthogonal Click Reactions," Material Matters, 7 (3), 35-38 (2012).

M.A. Azagarsamy, D.L. Alge, S.J. Radhakrishnan, M.W. Tibbitt, and K.S Anseth, "Photocontrolled Nanoparticles for On-Demand Release of Proteins," Biomacromolecules, 13 (8), 2219-2224 (2012).

H. Wang, S.M. Haeger, A.M. Kloxin, L.A. Leinwand, and K.S. Anseth, "Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-Mediated Reduction in Substrate Modulus," PLoS ONE, 7 (7), e39969 (2012).

M.W. Tibbitt, B.W. Han, A.M. Kloxin, and K.S. Anseth, "Synthesis and Application of Photodegradable Microspheres for Spatiotemporal Control of Protein Delivery," Journal of Biomedical Materials Research Part A, 100A (7), 1647-1654 (2012).

J.R. Popp, J.J. Roberts, D.V. Gallagher, K.S. Anseth, S.J. Bryant, and T.P. Quinn, "An Instrumented Bioreactor for Mechanical Stimulation and Real-Time, Nondestructive Evaluation of Engineered Cartilage Tissue," Journal of Medical Devices-Transactions of the ASME, 6 (2), UNSP 021006 (2012).

P.S. Hume, J. He, K. Haskins, and K.S. Anseth, "Strategies to Reduce Dendritic Cell Activation through Functional Biomaterial Design," Biomaterials, 33 (14), 3615-3625 (2012).

P.D. Mariner, E. Johannesen, and K.S. Anseth, "Manipulation of miRNA Activity Accelerates Osteogenic Differentiation of hMSCs in Engineered 3D Scaffolds," Journal of Tissue Engineered and Regenerative Medicine, 6 (4), 314-324 (2012).

C.A. DeForest and K.S. Anseth, "Photoreversible Patterning of Biomolecules within Click-Based Hydrogels," Angewandte Chemie-International Edition, 51 (8), 1816-1819 (2012).


C.A. DeForest and K.S. Anseth, "Cytocompatible Click-Based Hydrogels with Dynamically Tunable Properties Through Orthogonal Photoconjugation and Photocleavage Reactions," Nature Chemistry, 3 (12), 925-931 (2011).

P.S. Hume and K.S. Anseth, "Polymerizable Superoxide Dismutase Mimic Protects Cells Encapsulated in Poly(ethylene glycol) Hydrogels from Reactive Oxygen Species-Mediated Damage," Journal of Biomedical Materials Research Part A, 99A (1), 29-37 (2011).

P.S. Hume, C.N. Bowman, and K.S. Anseth, "Functionalized PEG Hydrogels Through Reactive Dip-Coating for the Formation of Immunoactive Barriers," Biomaterials, 32 (26), 6204-6212 (2011).

B.J. Berron, L.M. Johnson, X. Ba, J.D. McCall, N.J. Alvey, K.S. Anseth, and C.N. Bowman, "Glucose Oxidase-Mediated Polymerization as a Platform for Dual-Mode Signal Amplification and Biodetection," Biotechnology and Bioengineering, 108 (7), 1521-1528 (2011).

S.B. Anderson, C.C. Lin, D.V. Kuntzler, and K.S. Anseth, "The Performance of Human Mesenchymal Stems Cells Encapsulated in Cell-Degradable Polymer-Peptide Hydrogels," Biomaterials, 32 (14), 3564-3574 (2011).

B.D. Fairbanks, S.P. Singh, C.N. Bowman, and K.S. Anseth, "Photodegradable, Photoadaptable Hydrogels via Radical-Mediated Disulfide Fragmentation Reaction," Macromolecules, 44 (8), 2444-2450 (2011).

E.A. Sims, C.A. DeForest, and K.S. Anseth, "A Mild, Large-Scale Synthesis of 1,3-Cyclooctanedione: Expanding Access to Difluorinated Cyclooctyne for Copper-Free Click Chemistry," Tetrahedron Letters, 52 (16), 1871-1873 (2011).

C.C. Lin and K.S. Anseth, "Cell-Cell Communication Mimicry with Poly(ethylene glycol) Hydrogels for Enchancing Beta-Cell Function," PNAS, 108 (16), 6380-6385 (2011).

J.D. McCall, C.C. Lin, C.J., and K.S. Anseth, "Affinity Peptides Protect Transforming Growth Factor Beta During Encapsulation in Poly(ethylene glycol) Hydrogels," Biomacromolecules, 12 (4), 1051-1057 (2011).

B.J. Adzima, Y. Tao, C.J. Kloxin, C.A. DeForest, K.S. Anseth, and C.N. Bowman, "Spatial and Temporal Control of the Alkyne-Azide Cycloaddition by Photoinitiated Cu(II) Reduction," Nature Chemistry, 3 (3), 256-259 (2011).

R.K. Sivamani, M.P. Schwartz, K.S. Anseth, and R.R. Isseroff, "Keratinocyte Proximity and Contact can Play a Significant Role in Determining Mesenchymal Stem Cell Fate in Human Tissue," FASEB Journal, 25 (1), 122-131 (2011).

S. Pedron, C. Peinado, P. Bosch, J.A. Benton, and K.S. Anseth, "Microfluidic Approaches for the fabrication of Gradient Crosslinked Networks Based on Poly(ethylene glycol) and Hyperbranched Polymers for the Manipulation of Cell Interactions," Journal of Biomedical Materials Research Part A, 96A (1), 196-203 (2011).


A.M. Kloxin, M.W. Tibbitt, and K.S. Anseth, "Synthesis of Photodegradable Hydrogels as Dynamically Tunable Cell Culture Platforms," Nature Protocols, 5 (12), 1867-1887 (2010).

M.W. Tibbitt, A.M. Kloxin, K.U. Dyamenahalli, and K.S. Anseth, "Controlled Two-photon Photodegradation of PEG Hydrogels to Study and Manipulate Subcellular Interactions on Soft Materials," Soft Matter, 6 (20), 5100-5108 (2010).

A.M. Kloxin, C.J. Kloxin, C.N. Bowman, and K.S. Anseth, "Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination," Advanced Materials, 22 (13), 3484-3494 (2010).

B.D. Fairbanks, E.A. Sims, K.S. Anseth, and C.N. Bowman, "Reaction Rates and Mechanisms for Radical, Photoinitiated Addition of Thiols to Alkynes, and Implications for Thiol-yne Photopolymerizations and Click Reactions," Macromolecules 43 (9), 4113-4119 (2010).

C.A. DeForest, E.A. Sims, and K.S. Anseth, "Peptide-Functionalized Click Hydrogels with Independently Tunable Mechanics and Chemical Functionality for 3D Cell Culture," Chemistry of Materials, 22, 4783-4790 (2010).

L.M. Johnson, C.A. DeForest, A. Pendurti, K.S. Anseth, and C.N. Bowman, "Formation of Three-Dimensional Hydrogel Multilayers Using Enzyme-Mediated Redox Chain Initiation," ASC Appl Mater Interfaces, 2 (7), 1963-1972 (2010).

M.C. Lawson, K.C. Hoth, C.A. DeForest, C.N. Bowman, and K.S. Anseth, "Inhibition of Staphylococcus epidermidis Biofilms using Polymerizable Vancomycin Derivatives," Clin Orthop Relat Res, 468(8), 2081-2091 (2010).

A.A. Aimetti, K.R. Feaver, and K.S. Anseth, "Synthesis of Cyclic, Multivalent Arg-Gly-Asp Using Sequential Thiol-ene/Thiol-yne Photoreactions," Chemical Communications, 46 (31), 5781-3 (2010).

A.A. Aimetti, R.K. Shoemaker, C.-C. Lin, and K.S. Anseth, "On-resin Peptide Macrocyclization Using Thiol-ene Click Chemistry," Chemical Communications, 46 (23), 4061-4063 (2010).

M.P. Schwartz, B.D. Fairbanks, R.E. Rogers, R. Rangarajan, M.H. Zaman, and K.S. Anseth, "A Synthetic Strategy for Mimicking the Extracellular Matrix Provides New Insight About Tumor Cell Migration," Integrative Biology, 2, 32-40 (2010).

P.S. Hume and K.S. Anseth, "Induced Local T Cell Apoptosis with Anti-FAS-Functionalized Polymeric Coatings Fabricated Via Surface-Initiated Photopolymerizations," Biomaterials, 31, 3166-3174 (2010).

C.-C. Lin, P.D. Boyer, A.A. Aimetti, and K.S. Anseth, "Regulated MCP-1 Diffusion in Affinity Hydrogels for Enhancing Immuno-isolation," Journal of Controlled Release, 142 (3), 384-391 (2010).


J.A. Benton, C.A. DeForest, V. Vivekanandan, and K.S. Anseth, "Photocrosslinking of Geletin Macromers to Synthesize Porous Hydrogels that Promote Valvular Interstitial Cell Function," Tissue Engineering Part A, 15(11), 3221-3230 (2009).

B.D. Fairbanks, M.P. Schwartz, C.N. Bowman, and K.S. Anseth, "Photoinitiated Polymerization of PEG-diacrylate with Lithium phenyl-2,4,6-trimethylbenzoylphosphinate: Polymerization Rate and Cytocompatibility," Biomaterials, 30, 6702-6707 (2009).

M.C. Lawson, R. Shoemaker, K.B. Hoth, C.N. Bowman, and K.S. Anseth, "Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure-Function Evaluation," Biomacromolecules, 10, 2221-2234 (2009).

B.D. Fairbanks, M.P. Schwartz, A. E. Halevi, C.R. Nuttleman, C.N. Bowman, and K.S. Anseth, "A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photoolymerization," Advanced Materials, 21(48), 5005-5010 (2009).

J.A. Benton, B.D. Fairbanks, and K.S. Anseth, "Characterization of Valvular Interstitial Cell Function in Three Dimensional Matrix Metalloproteinase Degradable PEG Hydrogels," Biomaterials, 30, 6593-6603 (2009).

A.A. Aimetti, A.J. Machen, and K.S. Anseth, "Poly(ethylene glycol) Hydrogels Formed by Thiol-ene Photopolymerization for Enzyme-Responsive Protein Delivery," Biomaterials, 30, 6048-6054 (2009).

C.-C. Lin and K.S. Anseth, "Glucagon-like Peptide-1 Functionalized PEG Hydrogels Promote Survival and Function of Encapsulated Pancreatic β-cells," Biomacromolecules, 10, 2460-2467(2009).

A.M. Kloxin, J.A. Benton, and K.S. Anseth, "In Situ Elasticity Modulation with Dynamic Substrates to Direct Cell Phenotype," Biomaterials, 31 (2009).

A.M. Kloxin, M.W. Tibbitt, A.M. Kasko, J.F. Fairbairn, and K.S. Anseth, "Tunable Hydrogels for External Manipulation of Cellular Microenvironments Through Controlled Photodegradation," Advanced Materials, 21, (2009).

M.W. Tibbitt and K.S. Anseth, "Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture," Biotechinology and Bioengineering, 103, 655-663 (2009).

C.A. DeForest, B.D. Polizzotti, and K.S. Anseth, "Sequential Click Reactions for Synthesizing and Patterning Three-Dimensional Cell Microenvironments," Nature Materials, 8, 659-664 (2009).

C.-C. Lin, A.T. Metters, and K.S. Anseth, "Functional PEG-Peptide Hydrogels to Modulate Local Inflammation Induced by the Pro-Inflammatory Cytokine TNFα," Biomaterials, 30, 4907-4914 (2009).

C.-C. Lin and K.S. Anseth, "Controlling Affinity Binding in Peptide Functionalized Poly(ethylene glycol) Hydrogels," Advanced Functional Materials, 19, 2325-2331 (2009).

A.A. Aimetti, M.W. Tibbitt, and K.S. Anseth, "Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels ," Biomacromolecules, 10(6):1484-9 (2009).

A.M. Kloxin, A.M. Kasko, C.N. Salinas, and K.S. Anseth, "Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties," Science, 324, 59-63 (2009).

C.-C. Lin and K.S. Anseth, "PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine," Pharmaceutical Research, 26, 631-43 (2009).

B.D. Fairbanks, T.F. Scott, C.J. Kloxin, K.S. Anseth, and C.N. Bowman "Thiol-Yne Photopolymerization: Novel Mechanism, Kinetics, and Step-Growth Formation of Highly Cross-Linked Networks," Macromolecules, 42, 211-17 (2009).

M.A. Rice, K.R. Waters, and K.S. Anseth, "Ultrasound Monitoring of Cartilaginous Matrix Evolution in Degradable PEG Hydrogels," Acta Biomaterialia, 5, 152-61 (2009).


L.M. Weber, K.N. Hayda, and K.S. Anseth, "Cell-Matrix Interactions Improve beta-Cell Survival and Insulin Secretion in Three-Dimensional Culture," Tissue Engineering Part A, 14, 1959-68 (2008).

J.A. Benton, H.B. Kern, and K.S. Anseth, "Substrate Properties Influence Calcification in Valvular Interstitial Cell Culture,"Journal of Heart Valve Disease, 17, 689-99 (2008).

C.Y. Cheung, S.J. McCartney, and K.S. Anseth, "Synthesis of Polymerizable Superoxide Dismutase Mimetics to Reduce Reactive Oxygen Species Damage in Transplanted Biomedical Devices," Advanced Functional Materials, 18, 3119-26 (2008).

V.S. Khire, A.M. Kloxin, C.L. Couch, K.S. Anseth, and C.N. Bowman, "Synthesis, Characterization and Cleavage of Linear Polymers Attached to Silica Nanoparticles Formed Using Thiol-Acrylate Conjugate Addition Reactions," Journal of Polymer Science Part A-Polymer Chemistry, 46, 6896-6906 (2008).

M.A. Rice, P.M. Homier, K.R. Waters, and K.S. Anseth, "Effects of Directed Gel Degradation and Collagenase Digestion on the Integration of Neocartilage Produced by Chondrocytes Encapsulated in Hydrogel Carriers," Journal of Tissue Engineering and Regenerative Medicine, 2, 418-29 (2008).

L.M. Weber and K.S. Anseth, "Hydrogel Encapsulation Environments Functionalized with Extracellular Matrix Interactions Increase Islet Insulin Secretion," Matrix Biology, 27, 667-73 (2008).

D.S.W. Benoit, M.P. Schwartz, A.R. Durney, and K.S. Anseth, "Small Functional Groups for Controlled Differentiation of Hydrogel-Encapsulated Human Mesenchymal Stem Cells," Nature Materials, 10, 816-23 (2008).

C.N. Salinas and K.S. Anseth, "Mixed Mode Thiol-Acrylate Photopolymerization for the Synthesis of PEG-Peptide Hydrogels," Macromolecules, 41, 6019-26 (2008).

A.M. Kloxin and K.S. Anseth, "Protein Gels on the Move," Nature, 7205, 705-6(2008).

C.N. Salinas and K.S. Anseth, "The Influence of the RGD Peptide Motif and its Contextual Presentation in PEG Gels on Human Mesenchymal Stem Cell Viability," Journal of Tissue Engineering and Regenerative Medicine, 2, 296-304 (2008).

A.E. Rydholm, N.L. Held, D.S.W. Benoit, C.N. Bowman, and K.S. Anseth, "Modifying Network Chemistry in Thiol-Acrylate Photopolymers Through Postpolymerization Functionalization to Control Cell-Material Interactions," Journal of Biomedical Materials Research Part A, 86A, 23-30 (2008).

M.C. Cushing, P.D. Mariner, J.T. Liao, E.A. Sims, and K.S. Anseth, "Fibroblast Growth Factor Represses Smad-Mediated Myofibroblast Activation in Aortic Valvular Interstitial Cells," FASEB Journal, 22, 1769-77 (2008).

D.N. Shah, S.M. Recktenwall-Work, and K.S. Anseth, "The Effect of Bioactive Hydrogels on the Secretion of Extracellular Matrix Molecules by Valvular Interstitial Cells," Biomaterials, 29, 2060-72 (2008).

H.M. Simms, C.N. Bowman, and K.S. Anseth, "Using Living Radical Polymerization to Enable Facile Incorporation of Materials in Microfluidic Cell Culture Devices," Biomaterials, 29, 2228-36 (2008).

C.N. Salinas and K.S. Anseth, "The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities," Biomaterials, 29, 2370-77 (2008).

B.D. Polizzotti, B.D. Fairbanks, and K.S. Anseth, "Three-dimensional Biochemical Patterning of Click-based Composite Hydrogels via Thiolene Photopolymerization," Biomacromolecules, 9, 1084-7 (2008).

C.R. Nuttelman, M.A. Rice, A.E. Rydholm, D.N. Shah, and K.S. Anseth, "Macromolecular Monomers for the Synthesis of Hydrogel Niches and Their Application in Cell Encapsulation and Tissue Engineering," Progress in Polymer Science, 33, 167-79 (2008).

L.M. Weber, C.Y. Cheung, and K.S. Anseth, "Multifunctional pancreatic islet encapsulation barriers achieved via multilayer PEG hydrogels,"Cell Transplantation, 16, 1049-57 (2008).


D.S.W. Benoit, S.D. Collins, and K.S. Anseth, "Multifunctional Hydrogels that Promote Osteogenic Human Mesenchymal Stem Cell Differentiation Through Stimulation and Sequestering of Bone Morphogenic Protein 2," Advanced Functional Materials, 17, 2085-93 (2007).

M.C. Lawson, C.N. Bowman, and K.S. Anseth, "Vancomycin Derivative Photopolymerization to Titanium Kills S. epidermidis," Clinical Orthopaedics and Related Research, 461, 96-105 (2007).

M.C. Cushing, J-T. Liao, M.P. Jaeggli, and K.S. Anseth, "Material-Based Regulation of the Myofibroblast Phenotype," Biomaterials, 28, 3378-87 (2007).

K.K. Macdonald, C.Y. Cheung, and K.S. Anseth, "Cellular Delivery of TGF-beta1 Promotes Osteoinductive Signalling for Bone Regeneration," Journal of Engineering and Regenerative Medicine, 1, 314-17 (2007).

A.E. Rydholm, S.K. Reddy, K.S. Anseth, and C.N. Bowman "Development and Characterization of Degradable Thiol-Allyl Ether Photopolymers," Polymer, 48, 4589-4600 (2007).

A.W. Watkins, S.L. Southard, and K.S. Anseth, "Characterizing Multilaminated Hydrogels with Spatially Varying Network Structure and Solute Loading Using Confocal Laser Scanning Microscopy," Acta Biomaterialia, 3, 439-448 (2007).

A.E. Rydholm, K.S. Anseth, and C.N. Bowman "Effects of Neighboring Sulfides and pH on Ester Hydrolysis in Thiol-Acrylate Photopolymers," Acta Biomaterialia, 3, 449-455 (2007).

L.M. Weber, K.N. Hayda, K. Haskins, and K.S. Anseth, "The Effects of Cell-Matrix Interactions on Encapsulated Beta-Cell Function within Hydrogels Functionalized with Matrix-Derived Adhesive Peptides," Biomaterials, 28, 3004-11 (2007).

C.N. Salinas, B.B. Cole, A.M. Kasko, and K.S. Anseth, "Chondrogenic Differentiation Potential of Human Mesenchymal Stem Cells Photoencapsulated within Poly(ethylene glycol)-Arginine-Glycine-Aspartic Acid-Serine Thiol-Methacrylate Mixed-Mode Networks," Tissue Engineering, 13, 1025-34 (2007).

M.C. Cushing and K.S. Anseth, "Hydrogel Cell Cultures," Science, 316, 1133-34 (2007).

D.S.W. Benoit, M.C. Tripodi, J.O. Blanchette, S.J. Langer, L.A. Leinwand, and K.S. Anseth, "Integrin-Linked Kinase Production Prevents Anoikis in Human Mesenchymal Stem Cells," Journal of Biomedical Materials Research Part A, 81A, 269-278 (2007).

M.J. Mahoney and K.S. Anseth, "Contrasting Effects of Collagen and bFGF-2 on Neural Cell Function in Degradable Synthetic PEG Hydrogels," Journal of Biomedical Materials Research Part A, 81A, 1133-34 (2007).

E.M. Christenson, K.S. Anseth, J.J.P. van den Beucken, C.K. Chan, B. Ercan, J.A. Jansen, C.T. Laurencin, W.J. Li, R. Murugan, L.S. Nair, S. Ramakrishna, R.S. Tuan, T.J. Webster and A.G. Mikos, "Nanobiomaterial Applications in Orthopaedics," Journal of Orthopaedic Research, 25, 11-22 (2007).

J.A. Cooper, W.J. Li, L.O. Bailey, S.D. Hudson, S. Lin-Gibson, K.S. Anseth, R.S. Tuan and N.R. Washburn, "Encapsulated Chondrocyte Response in a Pulsatile Flow Bioreactor," Acta Biomaterialia,3, 13-21 (2007).

D.S.W. Benoit, A.R. Durney, and K.S. Anseth, "The Effects of Heparin-functionalized PEG Hydrogels on Three-dimensional Human Mesenchymal Stem Cell Osteogenic Differentiation," Biomaterials, 28, 66-77 (2007).

R.P. Sebra, S.K. Reddy, K.S. Masters, C.N. Bowman, and K.S. Anseth, "Controlled Polymerization Chemistry to Graft Architectures that Influence Cell-Material Interactions," Acta Biomaterialia,3, 151-161 (2007).

M.A. Rice and K.S. Anseth, "Controlling Cartilaginous Matrix Evolution in Hydrogels with Degradation Triggered by Exogenous Addition of an Enzyme," Tissue Engineering, 13,683-691 (2007).

K.W. Riddle, H.J. Kong, K.J. Leach, C. Fischbach, C.Y. Cheung, K.S. Anseth, and D.J. Mooney, "Modifying the Proliferative State of Target Cells to Control DNA Expression and Identifying Cell Types Transfected In Vivo," Molecular Therapy, 15, 361-8 (2007).


M.J. Mahoney and K.S. Anseth, "Contrasting Effects of Collagen and bFGF-2 on Neural Cell Function in Degradable Synthetic PEG Hydrogels," Journal of Biomedical Materials Research, 81A, 269-78 (2006).

A.E. Rydholm, S.K. Reddy, K.S. Anseth, and C.N. Bowman, "Controlling Network Structure in Degradable Thiol-Acrylate Biomaterials to Tune Mass Loss Behavior," Biomacromolecules, 7,2827-36 (2006).

V.S. Khire, D.S.W. Benoit, K.S. Anseth, and C.N. Bowman, "Ultrathin gradient films using thiol-ene polymerizations," Journal of Polymer Science, Polymer Chemistry, 44, 7027-39 (2006).

D.S.W. Benoit, C.R. Nuttelman, S.D. Collins, and K.S. Anseth, "Synthesis and Characterization of a Fluvastatin-Releasing Hydrogel Delivery System to Modulate hMSC Differentiation and Functions for Bone Regeneration," Biomaterials, 27, 6102-10 (2006).

M.A. Rice, J. Sanchez-Adams, and K.S. Anseth, "Exogenously Triggered, Enzymatic Degradation of Photopolymerized Hydrogels with Polycaprolactone Subunits: Experimental Observation and Modelling of Mass Loss Behavior," Biomacromolecules, 7(6): 1968-1975, (2006).

C.Y. Cheung and K.S. Anseth, "Synthesis of immunoisolation barriers that provide localized immunosuppression for encapsulated pancreatic islets," BioconjugateChemistry, 17, 1036-42 (2006).

V.S. Khire, A.W. Harant, A.W. Watkins, K.S. Anseth, and C.N. Bowman, "Ultrathin Patterned Polymer Films on Surfaces using Thiol-ene Polymerizations," Macromolecules, 39, 5081-86 (2006).

R.P. Sebra, K.S. Anseth, and C.N. Bowman, "Integrated surface modification of fully polymeric microfluidic devices using living radical photopolymerization chemistry," Journal of Polymer Science, Polymer Chemistry, 44, 1404-13 (2006).

L.M. Weber, J. He, B. Bradley, K. Haskins, and K.S. Anseth, "PEG-based hydrogels as an in vitroencapsulation platform for testing controlled beta cell microenvironments," ActaBiomaterialia, 2, 1-8 (2006).

C.R. Nuttelman, A.M. Kloxin, and K.S. Anseth, "Temporal Changes in PEG Hydrogel Structure Influence Human Mesenchymal Stem Cell Proliferation and Matrix Mineralization," Advances in Experimental Medicine and Biology, in press (2006).

C.R. Nuttelman, M.C. Tripodi, and K.S. Anseth, "Dexamethasone-Functionalized Gels Induce Osteogenic Differentiation of Encapsulated hMSCs," Journal of Biomedical Materials Research, 76A, 183-95 (2006).

K.T. Haraldsson, J.B. Hutchison, R.P. Sebra, B.T. Good, K.S. Anseth, and C.N. Bowman, "3D polymeric microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP)," Sensors and Actuators B, 113, 454-60 (2006).

D.S.W. Benoit, A.R. Durney, and K.S. Anseth, "Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation," Tissue Engineering, 12, 1663-1673 (2006).

M.J. Mahoney and K.S. Anseth, "Three-Dimensional Growth and Function of Neural Tissue in Degradable Polyethylene Glycol Hydrogels," Biomaterials, 27, 2665-74 (2006).

C.R. Nuttelman, D.S.W. Benoit, M.C. Tripodi, and K.S. Anseth, "The Effects of Ethylene Glycol Methacrylate Phosphate in PEG Hydrogels on Mineralization and Viability of Encapsulated hMSCs," Biomaterials, 27, 1377-1386 (2006).

R.P. Sebra, K.S. Masters, C.Y. Cheung, C.N. Bowman, and K.S. Anseth, "Detection of Antigens in Biologically Complex Fluid with Photografted Whole Antibodies," Analytical Chemistry, 78,3144-51 (2006).


J.B. Hutchison, P.F. Stark, C.J. Hawker, and K.S. Anseth, "Polymerizable Living Free Radical Initiators as a Platform to Synthesize Functional Networks," Chemistry of Materials, 17, 4789-97 (2005).

D.S.W. Benoit and K.S. Anseth, "Heparin Functionalized PEG Hydrogels that Modulate Protein Adsorption for hMSC Adhesion and Differentiation," Acta Biomaterialia, 1, 461-470 (2005).

S.K. Reddy, K.S. Anseth, and C.N. Bowman, "Modeling of Network Degradation in Mixed Step-Chain Growth Polymerizations," Polymer, 46, 4212-22 (2005).

C.R. Nuttelman, M.C. Tripodi, and K.S. Anseth, "Synthetic Hydrogel Niches that Promote hMSC Viability," Matrix Biology, 24, 208-18 (2005).

M.C. Cushing, K.S. Masters, L.A. Leinwand, and K.S. Anseth, "Serum Deprivation Improves Seeding and Repopulation of Acellular Matrices with Valvular Interstitial Cells," Journal of Biomedical Materials Research, 75A, 232-41 (2005).

S.K. Reddy, R.P. Sebra, K.S. Anseth, and C.N. Bowman, "Living Radical Photopolymerization Induced Grafting on Thiol-Ene Based Substrates," Journal of Polymer Science, Part A: Polymer Chemistry, 43, 2134-44 (2005).

D.S.W. Benoit and K.S. Anseth, "The Effect on Osteoblast Function of Colocalized RGD and PHSRN Epitopes on PEG Surfaces," Biomaterials, 26, 5209-20 (2005).

H.S. Simms, C.M. Brotherton, B.T. Good, R.H. Davis, K.S. Anseth, and C.N. Bowman, "In Situ Fabrication of Macroporous Polymer Networks within Microfluidic Devices by Living Radical Photopolymerization and Leaching," Lab on a Chip, 5, 151-57 (2005).

A.E. Rydholm, C.N. Bowman, and K.S. Anseth, "Degradable Thiol-Acrylate Photopolymers: Polymerization and Degradation Behavior of an In Situ Forming Biomaterial," Biomaterials, 26, 4495-506 (2005).

S.J. Bryant, J.A. Arthur, and K.S. Anseth, "Incorporation of Tissue-Specific Molecules Alters Chondrocyte Metabolism and Gene Expression in Photocrosslinked Hydrogels," Acta Biomaterialia, 1, 243-52 (2005).

A.W. Watkins and K.S. Anseth, "Investigation of Molecular Transport and Distributions in Poly(ethylene glycol) Hydrogels with Confocal Laser Scanning Microscopy," Macromolecules, 38, 1326-34 (2005).

T.M. Lovestead, J.A. Burdick, K.S. Anseth, and C.N. Bowman, "Understanding Multivinyl Monomer Photopolymerization Kinetics through Modeling and GPC Investigation of Degradable Networks," Polymer, 16, 6226-34 (2005).

K.S. Masters, D.N. Shah, L.A. Leinwand, and K.S. Anseth, "Crosslinked Hyaluronan Scaffolds as a Biologically Active Carrier for Valvular Interstitial Cells," Biomaterials, 26, 2517-25 (2005).


J. B. Hutchison, A. Lindquist and K.S. Anseth, "Off-Lattice Simulation of Multifunctional Monomer Polymerizations: Effects of Monomer Mobility, Structure, and Functionality on Structural Evolution at Low Conversion," Journal of Physical Chemistry B, 108, 11097-11104 (2004).

D.J. Quick, K.K. Macdonald, and K.S. Anseth, "Delivering DNA from Photocrosslinked, Surface-eroding Polyanhydrides," Journal of Controlled Release, 97, 333-43 (2004).

J.B. Hutchison, K.T. Haraldsson, B.T. Good, R.P. Sebra, N. Luo, K.S. Anseth, and C.N. Bowman, "Robust Polymer Microfluidic Device Fabrication Via Contact Liquid Photolithographic Polymerization (CLiPP)," Lab on a Chip, 4, 658-62 (2004).

J.B. Hutchison, A.S. Lindquist, and K.S. Anseth, "Experimental Characterization of Structural Features during Radical Chain Homopolymerization of Multifunctional Monomers Prior to Macroscopic Gelation: Application to Methacrylic Anhydride," Macromolecules, 37, 3823-31 (2004).

S.J. Bryant, K.A. Davis-Arehart, N. Luo, R.K. Shoemaker, J.A. Arthur, and K.S. Anseth, "Synthesis and Characterization of Photopolymerized Multifunctional Hydrogels: Water-soluble Poly(vinyl alcohol) and Chondroitin Sulfate Macromers for Chondrocyte Encapsulation," Macromolecules, 37, 6726-33 (2004).

K.S. Masters, D.N. Shah, G. Walker, L.A. Leinwand, and K.S. Anseth, "Designing Scaffolds for Valvular Interstitial Cells: Cell Adhesion and Function on Naturally-Derived Materials," Journal of Biomedical Materials Research, 71A, 172-80 (2004).

M.A. Rice and K.S. Anseth, "Encapsulating Chondrocytes in Copolymer Gels: Bimodal Degradation Kinetics Influence Cell Phenotype and Extracellular Matrix Development," Journal of Biomedical Materials Research, 70A, 560-68 (2004).

S.J. Bryant, T.T. Chowdhury, K.S. Anseth, D.A. Lee and D.L. Bader, "Crosslinking Density Influences the Morphology of Chondrocytes Photoencapsulated in PEG Hydrogels During the Application of Compressive Strain," Journal of Orthopaedic Research, 22, 1143-49 (2004).

S.J. Bryant, R.J. Bender, K.L. Durand, and K.S. Anseth,"Encapsulating Chondrocytes in Degrading PEG Hydrogels with High Modulus: Engineering Gel Structural Changes to Facilitate Cartilaginous Tissue Production," Biotechnology and Bioengineering, 86, 747-55 (2004).

G.A. Walker, K.S. Masters, D.N. Shah, K.S. Anseth, and L.A. Leinwand, "Valvular Myofibroblast Activation by TGF-beta: Implications for Pathological ECM Remodeling in Heart Valve Disease," Circulation Research, 95, 253-60 (2004).

P.J. Martens, C.N. Bowman, and K.S. Anseth,"Degradable Networks Formed from Multifunctional Poly(Vinyl Alcohol) Macromers: Comparison of Results from a Generalized Bulk-Degradation Model for Polymer Networks and Experimental Data," Polymer, 45, 3377-3387 (2004).

D.J. Quick and K.S. Anseth, "DNA Delivery from Photocrosslinked PEG Hydrogels: Encapsulation Efficiency, Release Profiles, and DNA Quality," Journal of Controlled Release, 96(2), 341-51 (2004).

C.R. Nuttelman, M.C. Tripodi, and K.S. Anseth, "In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells Photoencapsulated in PEG Hydrogels," Journal of Biomedical Materials Research, 68A(4), 773-82 (2004).

S.J. Bryant, T.T. Chowdhury, D.A. Lee, D.L. Bader, and K.S. Anseth, "Crosslinking Density Influences Chondrocyte Metabolism in Dynamically Loaded Photocrosslinked PEG Hydrogels," Annals of Biomedical Engineering, 32, 407-17, (2004).


M.A. Randolph, K.S. Anseth, and M.J. Yaremchuk, "Tissue Engineering of Cartilage,"Clinics in Plastic Surgery, 30,519-37 (2003).

D.J. Quick and K.S. Anseth, "Gene Delivery in Tissue Engineering: A Photopolymer Platform to Co-encapsulate Cells and Plasmid DNA," Pharmaceutical Research, 20, 1730-37 (2003).

N. Luo, A.T. Metters, J.B. Hutchison, C.N. Bowman, and K.S. Anseth, "A Methacrylated Photoinferter as a Chemical Basis for Microlithography: Micropatterning Based on Photo-Grafting Polymerization," Macromolecules, 36, 6739-45 (2003).

S.J. Bryant, K.L. Durand, and K.S. Anseth, "Manipulations in Hydrogel Chemistry Control Photoencapsulated Chondrocyte Behavior and their Extracellular Matrix Production," Journal of Biomedical Materials Research, 67, 1430-36 (2003).

J. Owens, K.S. Anseth, and T.W. Randolph, "Mechanism of Microparticle Formation in the Compressed Antisolvent Precipitation and Photopolymerization Process," Langmuir, 19, 3926-34 (2003).

A.W. Watkins and K.S. Anseth, "Copolymerization of Photocrosslinkable Anhydride Monomers for Use as a Biodegradable Bone Cement,"Journal of Biomaterials Science, Polymer Edition, 14,267-78 (2003).

J.A. Burdick, T.M. Lovestead, and K.S. Anseth, "Kinetic Chain Lengths in Highly Crosslinked Networks Formed by the Photoinitiated Polymerization of Degradable Divinyl Monomers: A GPC Investigation," Biomacromolecules, 4, 149-56 (2003).

K.A. Davis, J.A. Burdick, and K.S. Anseth, "Photoinitiated Crosslinked Degradable Copolymer Networks for Tissue Engineering Applications," Biomaterials, 24, 2485-95 (2003).

A.K. Poshusta, J.A. Burdick, D.J. Mortisen, R.F. Padera, D. Ruehlman, M.J. Yaszemski, and K.S. Anseth, "Histocompatibility of Photocrosslinked Polyanhydrides: A Novel In Situ Forming Orthopaedic Biomaterial," Journal of Biomedical Materials Research, 64A,62-69 (2003).

P.J. Martens, S.J. Bryant, and K.S. Anseth, "Tailoring the Degradation of Hydrogels Formed from Multivinyl Poly(ethylene glycol) and Poly(vinyl alcohol) Macromers for Cartilage Tissue Engineering," Biomacromolecules, 4, 283-92 (2003).

S.J. Bryant and K.S. Anseth, "Controlling the Spatial Distribution of ECM Components in Degradable PEG Hydrogels for Tissue Engineering Cartilage," Journal of Biomedical Materials Research, 64A, 70-79 (2003).


K.A. Davis and K.S. Anseth, "Controlled Release from Crosslinked Degradable Networks," Critical Reviews in Therapeutic Drug Carrier Systems, 19,385-423 (2002).

J.A. Burdick, R.F. Padera, J.V. Huang, and K.S. Anseth, "An Investigation of the Cytotoxicity and Histocompatibility of In SituForming Lactic Acid Based Orthopaedic Biomaterials," Journal of Biomedical Materials Research, Applied Biomaterials, 63, 484-91 (2002).

J.A. Burdick, D. Frankel, W.S. Dernell, and K.S. Anseth, "An Initial Investigation of Photocurable 3-Dimensional Lactic Acid Based Scaffolds in a Critical-Sized Cranial Defect," Biomaterials, 24, 1613-20 (2003).

J.A. Burdick, M.N. Mason, A.D. Hinman, K. Thorne, and K.S. Anseth, "Delivery of Osteoinductive Growth Factors from Degradable PEG Hydrogels Influences Osteoblast Differentiation and Mineralization," Journal of Controlled Release, 83, 53-63 (2002).

P. Martens, T. Holland and K.S. Anseth, "Synthesis and Characterization of Degradable Hydrogels Formed from Acrylate Modified Poly(Vinyl Alcohol) Macromers," Polymer, 43, 6093-6100 (2002).

A.K. Poshusta, C.N. Bowman, and K.S. Anseth, "Application of a Kinetic Gelation Simulation to the Characterization ofIn SituCrosslinking Biomaterials,"Journal of Biomaterials Science, Polymer Edition,13,797-815 (2002).

J.A. Burdick and K.S. Anseth, "Photoencapsulation of Osteoblasts in Injectable RGD-Modified PEG Hydrogels for Bone Tissue Engineering Applications," Biomaterials, 23, 4315-23 (2002).

S.J. Bryant and K.S. Anseth, "Hydrogel Properties Influence ECM Production by Chondrocytes Photoencapsulated in Poly(ethylene glycol) Hydrogels," Journal of Biomedical Materials Research, 59,63-72 (2002).

K.S. Anseth and J.A. Burdick, "New Directions in Photopolymerizable Biomaterials," MRS Bulletin, 1-7, (Feb., 2002).

C.R. Nuttelman, S.M. Henry, and K.S. Anseth, "Synthesis and Characterization of Photocrosslinkable, Degradable Poly(vinyl alcohol)-based Tissue Engineering Scaffolds," Biomaterials, 23,3617-26 (2002).

J.L Owens, K.S. Anseth, and T.W. Randolph, "Compressed Antisolvent Precipitation and Polymerization to Form Highly Crosslinked Polymer Particles," Macromolecules, 35, 4289-96 (2002).

N. Luo, J.B. Hutchison, K.S. Anseth, and C.N. Bowman, "Synthesis of A Novel Methacrylic Monomer-Iniferter and Its Application in Surface Photo-Grafting on Crosslinked Polymer Substrates,"Journal of Polymer Science Part A: Polymer Chemistry, 40,1885-91 (2002).

N. Luo, J.B. Hutchison, K.S. Anseth, and C.N. Bowman, "Surface-Initiated Photopolymerization of Poly(ethylene glycol) Methyl Ether Methacrylate on a Diethyldithiocarbamate-Mediated Polymer Substrate," Macromolecules, 35,2487-93 (2002).

K.S. Anseth, A.T. Metters, S.J. Bryant, P.J. Martens, J.H. Elisseeff,  and C.N. Bowman, "In SituForming Degradable Networks and Their Application in Tissue Engineering and Drug Delivery," Journal of Controlled Release, 78, 199-209 (2002).


L. Liew, W. Zhang, L. An, S. Shah, R. Luo, Y. Liu, T. Cross, M.L. Dunn, V. Bright, J.W. Daily, R. Raj and K.S. Anseth,"Ceramic MEMS: New Materials, Innovative Processing and Future Applications," American Ceramic Society Bulletin, 80, 25-30 (2001).

J.A. Burdick, M.N. Mason, and K.S. Anseth, "In Situ Forming Lactic Acid Based Orthopaedic Biomaterials: Influence of Oligomer Chemistry on Osteoblast Attachment and Function," Journal of Biomaterials Science, Polymer Edition, 12,1253-65 (2001).

C.R. Nuttelman, D.J. Mortisen, S.M. Henry, and K.S. Anseth, "Attachment of Fibronectin to Poly(Vinyl Alcohol) Hydrogels Promotes NIH3T3 Cell Adhesion, Proliferation, and Migration," Journal of Biomedical Materials Research, 57, 217-223 (2001).

J.B. Hutchison and K.S. Anseth, "An Off-Lattice Approach to Simulate Radical Chain Polymerization of Tetrafunctional Monomers," Macromolecular Theory and Simulations, 10, 600-607 (2001).

M. N. Mason, A.T. Metters, C.N. Bowman, and K.S. Anseth, "Predicting Controlled-Release Behavior of Degradable PLA-b-PEG-b-PLA Hydrogels," Macromolecules, 34, 4630-35 (2001).

J.A. Burdick, L.M. Philpott, and K.S. Anseth, "Synthesis and Characterization of Tetrafunctional Lactic Acid Oligomers: A Potential In Situ Forming Orthopaedic Biomaterial," Journal of Polymer Science, A, Polymer Chemistry, 39, 683-92 (2001).

P. Martens, A.T. Metters, K.S. Anseth, and C.N. Bowman, "A Generalized Bulk-Degradation Model for Hydrogel Networks Formed from Multi Vinyl Cross-linking Molecules," Journal of Physical Chemistry B, 105, 5131-38 (2001).

A.T. Metters, C.N. Bowman, and K.S. Anseth, "A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks: Incorporating Network Non-Idealities," Journal of Physical Chemistry B, 105, 8069-8076 (2001).

J.A. Burdick, A.J. Peterson, and K.S. Anseth, "Conversion and Temperature Profiles During the Photoinitiated Polymerization of Thick Orthopaedic Biomaterials," Biomaterials, 22, 1779-86 (2001).

A.K. Poshusta and K.S. Anseth, "Photopolymerized Biomaterials for Applications in the Temporomandibular Joint,"Cells Tissues Organs,169, 272-78 (2001).

D.J. Quick and K.S. Anseth, "Polymerizations of Multifunctional Anhydride Monomers to Form Highly Crosslinked Degradable Networks," Macromolecular Rapid Communications, 22, 564-72 (2001).

A.T. Metters, C.N. Bowman, and K.S. Anseth, "Verification of Scaling Laws for Degrading PLA-b-PEG-b-PLA Hydrogels," AIChE Journal, 47, 1432-37 (2001).

S.J. Bryant and K.S. Anseth, "The Effect of Scaffold Thickness on Tissue Engineered Cartilage in Photocrosslinked Poly(ethylene oxide) Hydrogels," Biomaterials, 22, 619-26 (2001).


A.T. Metters, K.S. Anseth and C.N. Bowman, "A Statistical Kinetic Model for the Bulk-Degradation of PEG-b-PLA Hydrogel Networks," Journal of Physical Chemistry B, 104, 7043-49 (2000).

P. Martens and K.S. Anseth, "Characterization of Hydrogels Formed from Acrylate Modified Poly (Vinyl Alcohol) Macromers," Polymer, 41, 7715-22 (2000).

A.K. Burkoth, J.A. Burdick, and K.S. Anseth, "Surface and Bulk Modifications to Photocrosslinked Polyanhydrides to Control Degradation Behavior," Journal of Biomedical Materials Research, 51, 352-59 (2000).

A.K. Burkoth and K.S. Anseth, "A Review of Photocrosslinked Polyanhydrides: In Situ Forming Degradable Networks," Biomaterials, 21, 2395-2404 (2000).

J. Elisseeff, W. McIntosh, K.S. Anseth, S. Riley, P. Ragan and R. Langer, "Photoencapsulation of Chondrocytes in Poly(Ethylene Oxide)-Based Semi-Interpenetrating Networks," Journal of Biomedical Materials Research, 51, 164-171 (2000).

S. Lu and K.S. Anseth, "Release Behavior of High Molecular Weight Solutes From Poly(ethylene glycol)-Based Degradable Networks," Macromolecules, 33, 2509-2515 (2000).

A.T. Metters, K.S. Anseth, and C.N. Bowman, "Fundamental Studies of a Novel, Biodegradable PEG-b-PLA Hydrogel," Polymer, 41, 3993-4004 (2000).

S. Lu, W.F. Ramirez, and K.S. Anseth, "Photopolymerized, Multilaminated Matrix Devices with Optimized Nonuniform Initial Concentration Profiles to Control Drug Release," Journal of Pharmaceutical Sciences, 89, 45-51 (2000).

J.S. Young, K.D. Gonzales, and K.S. Anseth, "Photopolymers in Orthopedics: Characterization of Novel Crosslinked Polyanhydrides," Biomaterials, 21, 1181-88 (2000).

S.J. Bryant, C.R. Nuttelman, and K.S. Anseth, "Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts," Journal of Biomaterials Science. Polymer Edition, 11, 439-57 (2000).