July 8, 2013
Jen Leight showed spatially resolved cellularly MMP activity through a FRET reporter peptide. She showed increased MMP expression in response to TGF-beta and higher substrate modulus. This is an excellent follow-up to her June Employee of the Month Award! Congratulations Jen!
J.L. Leight, D.L. Alge, A.J. Maier, and K.S. Anseth, "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrat," Biomaterials (2013)