Chris Koehler and Daniel Alge's paper "A Diels-Alder Modulated Approach to Control and Sustain the Release of Dexamethasone and Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells" was highlighted in Mesenchymal Cell News

April 4, 2013

From Mesenchymal Cell News:

Researchers report a new approach to controlled drug release based upon exploiting the dynamic equilibrium that exists between Diels-Alder reactants and products, demonstrating the release of a furan containing dexamethasone peptide from a maleimide containing hydrogel. Using a reaction-diffusion model, the release kinetics were tuned to achieve sustained concentrations conducive to osteogenic differentiation of human mesenchymal stem cells.