Pat Hume showed that immunosuppressive factors maintain their activity when tethered to a hydrogel and reduce markers of dendritic cell activation. The figure shows reduced levels of IL-12 expression in dendritic cells seeded upon hydrogels functionalized with immunosuppressive proteins TGF-B1 and IL-10.
P.S. Hume, J. He, K. Haskins, and K.S. Anseth, "Strategies to Reduce Dendritic Cell Activation through Functional Biomaterial Design," Biomaterials, 33 (14), 3615-3625 (2012).