Mark Opp
Integrative Physiology

Dr. Opp is a Professor in the Department of Integrative Physiology.  He received his PhD in Zoology from Washington State University in 1987.  After post-doctoral training at the University of Tennessee Memphis, he obtained an Assistant Professor faculty appointment in the Department of Psychiatry & Behavioral Sciences at the University of Texas Medical Branch in Galveston, TX.  In 2000, he was appointed Professor in the Department of Anesthesiology at the University of Michigan, Ann Arbor, MI.  Dr. Opp was recruited to the Department of Anesthesiology & Pain Medicine at the University of Washington, Seattle, WA, in 2010, where he served as Vice Chair for Basic Research and Director of Grants Administration.  In 2017, he joined the faculty of the Department of Integrative Physiology at UCB.  Dr. Opp’s research programs aim to elucidate sleep-immune interactions, specifically the role of chronic insufficient sleep in inflammatory disease.  Current projects use mouse models to determine mechanisms by which sleep disruption contributes to musculoskeletal pain, traumatic brain injury, and metabolic dysregulation.

Selected Publications

Sutton, B. C., and M. R. Opp.  Sleep fragmentation exacerbates mechanical hypersensitivity and alters subsequent sleep-wake behavior in a mouse model of musculoskeletal sensitization.  SLEEP 37: 515-524, 2014.

Ingiosi, A. M., R. M. Raymond, M. N. Pavlova, and M. R. Opp.  Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep. Brain, Behav. Immunity: 48: 244-257, 2015.

Ho, J. M., R. P. Barf, and M. R. Opp. Effects of sleep disruption and high fat intake on glucose metabolism in mice.  Psychoneuroendocrinology 68: 47-56, 2016.

Ingiosi, A. M., and M. R. Opp.  Sleep and immunomodulatory responses to systemic lipopolysaccharide in mice selectively expressing interleukin-1 receptor 1 on neurons or astrocytes. GLIA 64: 780-791. 2016.

Thomasy, H. E., H. Y. Febinger, K. M. Ringgold, C. Gemma, and M. R. Opp. Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury. Neurobiol. Sleep Circadian Rhythms. 2: 71-84, 2017.

Ho, Jacqueline, N. H. Ducich, N-Q. K. Nguyen, and M. R. Opp.  Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice.  Neurobiology of Sleep and Circadian Rhythms (