Antimicrobial-resistance is a growing global health concern with deaths from antimicrobial-resistant infections predicted to outnumber cancer deaths by the year 2050. Our group postulates that harnessing the body’s natural response to pathogen invasion by controlling innate immune cell function could be an effective way to combat infection. However, to precisely control cell function, we first need a better understanding of the signals that drive the innate immune response to infection. Our group works at the intersection of engineering and immunology, using our knowledge of design principles and immune cell biology to investigate the innate immune response to infection. We design biomimetic microfluidic models inspired by in vivo biology to investigate human immune cell behavior in a physiologically relevant environment. This work is carried out with the goal of discovering new targets to control immune cell recruitment, resolution, and anti-microbial function.