Publications

Publications from the Hind Lab at University of Colorado Boulder
  1. Owens JM, Weppner HK, Ignes-Romeu A, Burleson J#, and Hind LE. “Interleukin-6 Concentration Regulates the Neutrophil Response to Diverse Bacteria.” Frontiers of Immunology. Accepted.
  2. Calo CJ, Patil T#, Fouts J#, Ginter EL, Radke M, Weppner HK, Owens J, Hind LE+. “Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection-on-a-Chip Model.” Advanced NanoBiomed Research. Accepted.
  3. Weppner HK, Singh MA#, Katsnelson EN, Douin DJ, McCarter MD, Tobin RP, Hind LE+. “M-MDSCs Impair Neutrophil Migration in the Infectious Microenvironment.” JLB. 2025 Dec 1;117(12):qaif165. Doi:10.1093/jleuko/qaif165.
  4. Ignes-Romeu A and Hind LE+. “Innate Immune Crosstalk: The Central Role of Neutrophils and Macrophages in ANCA-Associated Vasculitis.” Molecular Biology of the Cell. 2025 Oct 29:mbcE25080392. Doi:10.1091/mbc.E25-08-0392.
  5. Calo CJ, Radke M, Patil T#, Hind LE+. “Regulation of Neutrophil Function by the Extracellular Matrix.” Biochemical Society Transactions. Review. 2025 Oct 16:BST20253020. Doi: 10.1042/BST20253020.
  6. Wiggin N, Cook C, Black M, Cadena I, Rahal-Arabi S, Asnes C, Ivanova Y, Hettiaratchi MH, Hind LE, Fogg K+. “Empowering high-throughput high-content analysis of microphysiological models: Open-source software for automated image analysis of microvessel formation and cell invasion.” Cellular and Molecular Bioengineering. 2024 Oct 10;17(5):369-383. Doi: 10.1007/s12195-024-00821-2.
  7. Ignes-Romeu A, Weppner H, Kaur T, Singh M#, Hind LE+. “Macrophages limit Neutrophil Extravasation in an Infection-on-a-Chip Model.” Cellular and Molecular Bioengineering. 2024 Jul 20;17(4):279-293. Doi:10.1007/s12195-024-00813-2.
  8. Calo CJ, Patil T#, Palizzi M#, Wheeler N#, Hind LE+. “Collagen Concentration Regulates Neutrophil Extravasation and Migration in Response to Infection in an Endothelium Dependent Manner.” Frontiers in Immunology. 2024 Jul 3:15:1405364.
  9. Richardson IM, Calo CJ, Ginter EL, Niehaus E#, Pacheco KA#, Hind LE+. “Diverse Bacteria Elicit Distinct Neutrophil Responses in a Physiologically Relevant Model of Infection.” iScience, 2023 Dec 2;27(1):108627.
  10. Richardson IM*, Calo CJ*, Hind LE+. “Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection,” Frontiers in Immunology, 2021 Apr 27;12:661537. 
Publications from Previous Institutions
  1. Klemm LC, Denu RA, Hind LE, Rocha-Gregg BL, Burkard ME, Huttenlocher A. “Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells.” Molecular Biology of the Cell, 2021 Aug 15;32(17):1545-1556.
  2. Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Beebe DJ. “A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment,” Integrative Biology, 2021 Apr 20;13(4):87-97.
  3. Hind LE, Giese MA, Schoen TJ, Keller NP, Beebe DJ, Huttenlocher A. “Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model,” Cellular and Molecular Bioengineering, 2020 Oct 13;14(2):133-145.
  4. McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. “Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control,” Lab Chip, 2019 Nov 7;19(21):3697-3705.
  5. Giese MA*, Hind LE*, Huttenlocher A. “Neutrophil plasticity in the tumor microenvironment,” Blood, 2019 May 16;133(20):2159-2167. *These authors contributed equally.
  6. Hind LE and Huttenlocher A. “Neutrophil Reverse Migration and a Chemokinetic Resolution,” Developmental Cell, 2018 Nov 19; 47(4):404-405.
  7. Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. “Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P. aeruginosa,” Blood, 2018 Oct 25;132(17):1818-1828.
  8. Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ. “An Accessible Organotypic Microvessel Model using iPSC-Derived Endothelium,” Advanced Healthcare Materials. 2018 Jan;7(2).
  9. Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. “Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues,” Cell Reports. 2017 May 23; 19(8): 1572-1585.
  10. Hind LE, Lurier EB, Dembo M, Spiller KL, Hammer DA. “Effect of M1-M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages,” Cellular and molecular bioengineering. 2016 September; 9(3):455-465.
  11. Hind LE, Vincent WJ, Huttenlocher A. “Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration,” Developmental Cell. 2016 Jul 25;38(2):161-9.
  12. Yamahashi Y*, Cavnar PJ*, Hind LE*, Berthier E, Bennin DA, Beebe D, Huttenlocher A. “Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D,” Biomedical Microdevices. 2015 Oct;17(5):100. *These authors contributed equally.
  13. Hind LE, Dembo M, Hammer DA, “Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness,” Integrative Biology, 2015 Apr; 7(4):447-453.
  14. Hind LE, MacKay JL, Cox D, Hammer, DA, “Two-dimensional motility of a macrophage cell line on microcontact-printed fibronectin,” Cytoskeleton, 2014 Sep; 71(9):542-554.
  15. Kamat NP, Liao Z, Moses LE, Rawson J, Therien MJ, Dmocjowski IJ, Hammer DA, “Sensing membrane stress with near IR-emissive porphyrins,” Proc Natl Acad Sci, 2011 Aug 23; 108(34).
  16. Mettallo CM, Azarin SM, Moses LE, Ji L, de Pablo JJ, Palecek SP. “Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs,” Tissue Engineering, Vol. A, (2009).