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This project examines the effect of individual and aggregate cardiovascular (CVD) risk factors on hearing using electronic health records from the University of Colorado School of Medicine (UCHealth) electronic health records. We will apply machine learning and statistical modeling to evaluate sex-based differences in CVD-related hearing loss to better understand which risk factor combinations are most detrimental to hearing health. We will generate sex-specific audiometric phenotypes associated with individual and aggregate CVD risk factors. Our approach to assessing hearing outcomes stands to improve early identification and intervention for at-risk patient populations. This work is being completed with Co-PI Dr. Melinda Anderson (University of Colorado School of Medicine) and statistical collaborator Dr. Eric Vance (CU Boulder, Applied Mathematics). This study is a retrospective review of health records and we are not enrolling new participants.
This project is funded by an Emerging Research Grant (Hearing Health Foundation). There are some risk factors for cardiovascular disease (such as tobacco smoking, diabetes, and hypertension) that also affect hearing. This study is designed for us to learn more about how these risk factors impact the hearing mechanism. We are seeking adults aged 18-55 years for this study. We are looking for people without risk factors as well as those with one or more of the following: (1) diabetes, (2) hypertension [or on medication], (3) high cholesterol [or on medication], and (4) tobacco smoking. The study involves a blood draw and approximately four hours of hearing testing. You can sleep through some of these tests. Free parking and compensation is provided. Please contact us if you are interested!
This is an ongoing AuD capstone study by Jennifer Masters. Hearing loss is associated with many risk factors for cardiovascular disease. These risk factors include tobacco smoking, diabetes, hypertension, and high cholesterol. This study will examine how these risk factors affect the hearing mechanism. The end product will be a comparison of audiological assessments of individuals with optimal health and individuals that have a high risk for cardiovascular disease. We are seeking adults aged 18-55 years for this study. We are looking for people without risk factors as well as those with one or more of the following: (1) diabetes, (2) hypertension [or on medication], (3) high cholesterol [or on medication], and (4) tobacco smoking. The study involves a blood draw and approximately four hours of hearing testing. You can sleep through some of these tests. Free parking and compensation is provided. Please contact us if you are interested!
This is an ongoing AuD capstone study by Eric Kinney. C-Reactive Protein is a marker for inflammation in the body that has been found to be a risk factor for cardiovascular disease. The purpose of this capstone project was to explore the association between inflammation, and its effect on the auditory system. Specifically, I am looking at blood levels of C-Reactive Protein, and how that relates to auditory profiles and the magnitude of 2f1-f2 distortion product otoacoustic emissions. This small scale analysis (N=32) will provide a comprehensive literature review on the topic and pave the way for a larger future analysis of how inflammation may lead to cochleopathy.
Hearing loss and cardiovascular disease risk profiles in the Hispanic Community Health Study/Study of Latinos
This project was funded by an Innovative Seed Grant (CU Boulder) and Emerging Research Grant (Hearing Health Foundation). This is a population-based study designed to explore the effects of cardiovascular disease risk factors on hearing in Hispanic/Latino individuals. We are not recruiting participants for this study.
This epidemiological study will explore the relationship between cochear function and cardiovascularr disease risk factors. In particular, we are interested in relationships with smoking, diabetes, high cholesterol, and hypertension. This study will use data from the Jackson Heart Study, which was designed to better understand cardiovascular disease risk and related health outcomes in African Americans. We are not recruiting participants for this study.
This project explored the effects of marijuana smoking on auditory function in young adults. We used distortion product otoacoustic emissions and electrophysiological tests to evaluate auditory function. This study is no longer enrolling participants. We are currently writing papers to report our findings.
This is a completed AuD capstone study by Samantha Brumbach. This work was supported in part by a University Fellowship from the Department of Speech, Language, and Hearing Sciences and the Beverly Sears Graduate Student Grant from the University of Colorado Boulder. There is some evidence to suggest that combusted cannabis use may increase one's risk for cardiovascular disease. As the link between hearing loss and other cardiovascular disease risk factors (tobacco smoking, diabetes, etc) are well supported this study was designed to determine if there is an association between long term combusted cannabis use and hearing loss. The study involved an extensive case history and several hours of hearing tests for both subjects that report regular cannabis use and subjects that report no history of cannabis use. The results of this study are currently being reviewed and we are no longer enrolling participants.
Optimizing Stimulus Frequency Ratio for Elicitation of the f2-f1 Distortion Product Otoacoustic Emission
Distortion product otoacoustic emissions (DPOAEs) at the frequency 2f1-f2 have been commonly studied. However, the DPOAE at f2-f1 has shown promise to detect certain cochleopathies, particularly endolymphatic hydrops. This investigation explored the optimal stimulus frequency ratio to elicit the f2-f1 DPOAE in young adult humans. We found that narrow elicitors are optimal.
Annotating Primary Scientific Literature – Professional Development Opportunity for Grad Students and Postdocs
Formal training in communicating scientific findings to a general audience is not generally part of the curriculum for graduate students, nor is it formally taught to postdoctoral fellows. However, we know that scientific communication is an important part of the job function for professional scientists. We designed and taught a class for graduate students and postdoctoral fellows on annotating primary scientific literature. This course increased confidence in scientific communication ability and increased readability of primary scientific literature.