Conservation and similarity of immunity

Conservation and similarity of bacterial and eukaryotic innate immunity

Feb. 28, 2024

Ledvina, HE, ➤Whiteley, AT | Nature Reviews Microbiology 2024

Bacteria Synthesize 2',3'-cGAMP

Bacterial cGAS-like enzymes produce 2′,3′-cGAMP to activate an ion channel that restricts phage replication

July 26, 2023

Tak U, Walth P, ➤Whiteley AT | BioRxiv 2023

Kibby et al 2023 Cell Artwork

Bacterial NLR-related proteins protect against phage

May 8, 2023

Kibby EM, Conte AN, Burroughs AN, Nagy TA, Vargas JA, Whalen LA, Aravind L, ➤Whiteley AT | Cell 2023

Ledivina and Ye et al Nature 2023

An E1–E2 fusion protein primes antiviral immune signalling in bacteria

Feb. 8, 2023

Ledvina HE*, Ye Q*, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD†, ➤Whiteley AT† (*equal contribution, †co-cor. author) | Nature 2023

JB Commentary

The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity

Nov. 19, 2020

Kibby EM, ➤Whiteley AT. | J. Bacteriology 2020

Graphical Abstract

CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

July 9, 2020

Lowey B, ➤Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. | Cell. 2020

CD-NTase Tree

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

March 1, 2019

➤Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ*, Kranzusch PJ* | Nature. 2019