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The Aaron Whiteley Research Group

The Aaron Whiteley Research Group

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  • Join Us!

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Welcome to the Whiteley Lab!

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What we do

Our immune system is the barrier that keeps pathogens, such as viruses and bacteria, from replicating in our bodies and causing disease. Virtually all organisms have some sort of immune system. Bacteria have an immune system that stops bacterial viruses (phages). Interestingly, the immune systems of humans and bacteria use similar “molecular machines” to recognize and respond to invading threats. Our lab studies these machines and the interplay between hosts and their pathogens in both humans and bacteria. The ultimate goal of our work is to better understand infectious diseases to enable development the next generation of therapeutics. Find more detail on our research here!

 

 

What we publish

Full List

 

Ledivina and Ye et al Nature 2023

An E1–E2 fusion protein primes antiviral immune signalling in bacteria

Feb. 8, 2023

Ledvina HE*, Ye Q*, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD†, ➤Whiteley AT† (*equal contribution, †co-cor. author) | Nature 2023

Read more about An E1–E2 fusion protein primes antiviral immune signalling in bacteria

Kibby et al BioRxiv 2022

Bacterial NLR-related proteins protect against phage

July 20, 2022

Kibby EM, Conte AN, Burroughs AN, Nagy TA, Vargas JA, Aravind L, ➤Whiteley AT | BioRxiv 2022

Read more about Bacterial NLR-related proteins protect against phage

JB Commentary

The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity

Nov. 19, 2020

Kibby EM, ➤Whiteley AT. | J. Bacteriology 2020

Read more about The linguistics of bacterial conflict systems reveal ancient origins of eukaryotic innate immunity

CD-NTase Tree

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

March 1, 2019

➤Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ*, Kranzusch PJ* | Nature. 2019

Read more about Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

 

 

Who we are

Our lab is a mixture of Ph.D. students, postdocs, scientists, undergraduates, and a guy named Aaron, all interested in microbiology. Find more about each of us here!

Lab whiteboard

JSCBB

 

Where we are

Situated at the foot of Colorado's Front Range and a mile high in elevation, our lab can be found in the new Jennie Smoly Caruthers Biotechnology Building (JSCBB). Our neighbors include labs from the Department of Biochemistry, the BioFrontiers Institute, and the Department of Chemical and Biological Engineering.


                                          
Publications

 


                                          
Research Topics

 


                                          
Team Members


                                          
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The Aaron Whiteley Research Group

University of Colorado Boulder
Department Biochemistry
Jennie Smoly Caruthers Biotechnology Building (JSCBB)
Boulder, Colorado

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University of Colorado Boulder

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