Xiuyang Xia, Ludwig-Maximilians-Universität München

Linker-mediated designed self-assembly and superselectivity

Using multiple weak bindings to form effectively strong interactions, namely multivalent interactions, constitutes the cornerstone of various biological processes. Compared to conventional multivalent bindings, indirect linker-mediated bridging provides new axes for regulating interactions by adjusting both the density and specificity of linkers. In this context, linkers are defined as small, dual-ended molecules capable of transiently and reversibly binding to receptors and ligands on host and guest structures, respectively. This creates bridges that connect these entities. The specificity of the linkers also enables in situ programmability, allowing for the precise “stitching” together of building blocks in synthetic multicomponent systems by introducing specific linkers.

I will present our recent work on the linker-mediated designed assembly of DNA-coated colloids and the superselectivity observed in linker-mediated multivalent nanoparticle adsorption. I will discuss the intriguing entropy-induced phase behaviors resulting from both valence-limited and multivalent natures. Additionally, I will highlight the potential application of the designed precise fabrication on nanoscale, as well as the design of new sensors to detect biomarkers.