Gehrels, Emily - Harvard University

From strand displacement to colloidal dancers: using DNA to program novel interactions

We present an experimental system of DNA-functionalized colloidal particles which exhibit directed motion (‘dancing’) along patterned substrates in response to temperature cycling. We take advantage of toehold exchange in the design of the DNA sequences that mediate the colloidal interactions to produce broadened, flat, or even re-entrant binding and unbinding transitions between the particles and substrate. Using this new freedom of design, we devise systems where, by thermal ratcheting, we can externally control the direction of motion and sequence of steps of the colloidal dancer.