(University of Puerto Rico—Mayaguez)
Research Project Description.
Proteins containing disordered domains perform many important cellular functions. My lab currently has two main projects, one to dissect the role of tubulin's C-terminal tail in microtubule structure and functions. The second focuses on selective transport through the nuclear pore complex. We are use microscopy, nuclear magentic resonance and other biophysical techniques complemented with modeling to approach these systems. This work includes using in cell NMR, a technique to study the structure and dynamics of proteins within living cells.