Publications
Colon Plaza S, Su TT. Ionizing radiation induces cells with past caspase activity that contribute to the adult organ in Drosophila and show reduced Loss of Heterozygosity. Cell Death Discov. 2024 Jan 5;10(1):6. doi: 10.1038/s41420-023-01769-4. PMID: 38182576
Brown J, Su TT. E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced Loss of Heterozygosity in Drosophila melanogaster. Genetics. 2023 Oct 24:iyad192. doi: 10.1093/genetics/iyad192. PMID: 37874851
Su TT. How to initiate tissue regeneration by generating mutually exclusive cell states. PLoS Biol. 2023 Jun 6;21(6):e3002155. doi: 10.1371/journal.pbio.3002155. PMID: 37279465; PMCID: PMC10243753. PMID: 37279465
Gomes NP, Frederick B, Jacobsen JR, Chapnick D, Su TT. A high throughput screen with a clonogenic endpoint to identify radiation modulators of cancer. Radiat Res. 2023 Feb 1;199(2):132-147. doi: 10.1667/RADE-22-00086.1. PMID: 36583948
Ledru M, Clark CC A, Brown J, Verghese S, Ferrara S, Goodspeed A and Su TT. Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila. PLoS Genet. 2022 Jan 6;18(1):e1009989. PMID: 34990447
Colon-Plaza S, Su TT. Non-Apoptotic Role of Apoptotic Caspases in the Drosophila Nervous System. Front Cell Dev Biol. 2022 Feb 9;10:839358. PMID: 35223857
Brown J, Bush I, Bozon J and Su TT. Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms. PLoS Genet. 2020 Oct 19;16(10):e1009056. PMID: 33075096
Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben D. Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. Radiation Res. 2020 Nov 10;194(5):519-531. PMID: 32936912
Keysar SB, Gomes N, Miller B, Jackson BC, Le PN, Morton JJ, Reisinger J, Chimed TS, Gomez KE, Nieto C, Frederick B, Pronk GJ, Somerset HL, Tan AC, Wang XJ, Raben D, Su TT*, Jimeno A*. (*co-corresponding authors). Inhibiting translation elongation with SVC112 suppresses cancer stem cells and inhibits growth in head and neck squamous carcinoma. Cancer Res. 2020 Jan 7. pii: canres.3232.2019. PMID: 31911553
Tin Tin Su. What Drosophila Can Teach Us About Radiation Biology of Human Cancers. Adv Exp Med Biol. 2019;1167:225-236. PMID: 31520358
Tin Tin Su. Drug screening in Drosophila; why, when, and when not?. Wiley Interdiscip Rev Dev Biol. 2019 Nov;8(6):e346, WIREs Developmental Biology. PMID: 31056843
Monn Monn Myat, Dheveline Louis, Andreas Mavrommatis, Latoya Collins, Jamal Mattis, Michelle Ledru, Shilpi Verghese, and Tin Tin Su. Regulators of cell movement during development and regeneration in Drosophila. Open Biology (The Royal Society). 2019 May 31;9(5):180245. PMID: 31039676
Summative Report on Internal Evaluation for LEAP, Leadership Education for Advancement and Promotion In Equity in STEM: Measurements, Methodologies, & Metrics for Research & Evaluation. Patricia Rankin, Joyce McCarl Nielsen, Carol Lynch, Todd Gleeson, Tin Tin Su, and Sandra Laursen. https://ssrn.com/abstract=3344658 (posted March 05 2019). Full Article Here
Verghese, S. and Su TT. Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila. PLoS Genet. 2018 Nov 21;14(11):e1007659. PMID: 30462636
Tin Tin Su. Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different. Open Biology (Royal Society), 28 November 2018.DOI: 10.1098/rsob.180157. PMID: 30487302
Robert J. Duronio, Patrick H. O'Farrell, Greenfield Sluder, Tin Tin Su. Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research. Disease Models and Mechanisms, 2017 10: 1381-1389; doi: 10.1242/dmm.031203.Full Article Here
Verghese, S. and Su TT. STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila. PLoS Genetics, 2017 Oct 13. PMID: 29028797
Verghese, S. and Su TT. Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation. PLoS Biology, 2016 Sep 1;14(9):e1002536. PMID: 27584613
Stickel SA, Gomes NP (co-first authors), Frederick B, Raben D, Su TT. Bouvardin Is A Radiation Modulator With A Novel Mechanism Of Action. Radiation Research, Oct;184(4):392-403. PMID: 26414509
Xing Y, Su TT, Ruohola-Baker H. Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster. Nat Commun. 2015 May 11;6:7058. PMID: 25959206
Tin Tin Su. Non-autonomous consequences of cell death and other perks of being metazoan. AIMS Genetics (review) Volume 2, Issue 1, Pages: 54 - 69, 2015. Open Access
Amber Bilak, Lyle Uyetake and Tin Tin Su. Dying cells protect survivors from radiation-induced cell death in Drosophila. PLoS Genetics, PLoS Genet. 2014 Mar 27;10(3):e1004220. PMID: 24675716
Stefanie Stickel and Tin Tin Su. Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins. Bio Open,. 2014 Mar 15;3(3):201-9. PMID:24570398
Stefanie Stickel, Nathan Gomes and Tin Tin Su. The Role of Translational Regulation in Survival after Radiation Damage; an Opportunity for Proteomics Analysis. Proteomes 2014, 2(2), 272-290. Open Access
van Bergeijk P, Heimiller J, Uyetake L, Su TT. Genome-Wide Expression Analysis Identifies a Modulator of Ionizing Radiation-Induced p53-Independent Apoptosis in Drosophila melanogaster. PLoS One. 2012;7(5):e36539. PMID:22666323
M. Gladstone*, B. Frederick*, D. Zheng, A. Edwards, P. Yoon, S. Stickel, T. DeLaney, D. C. Chan, D. Raben, T. T. Su. A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer. (*shared first authors) Disease Models and Mechanisms. 2012 May;5(3):342-50. PMID:22344740
A. Edwards*, Mara Gladstone*, P. Yoon, D. Raben, Barbara Frederick, T. T. Su, Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells, Disease Models and Mechanisms. (*shared first authors) 2011 Jul;4(4):496-503. Epub 2011 Apr 18. PubMed ID:21504911
Smith MK, Trujillo C, Su TT. The benefits of using clickers in small-enrollment seminar-style biology courses. CBE Life Sci Educ. 2011 Spring;10(1):14-7. PMID:21364096
M. Gladstone & T. T. Su. Radiation Responses and Resistance. International Review of Cell and Molecular Biology, 2012;299:235-53. PMID:22959305
M. Gladstone & T. T. Su. Chemical genetics and drug screening in Drosophila cancer models. J. Genetics and Genomics, 2011 Oct 20;38(10):497-504. PMID:22035870
Su TT. Safeguarding genetic information in Drosophila. Chromosoma. 2011 Dec;120(6):547-55. doi: 10.1007/s00412-011-0342-9. Epub 2011 Sep 17. PMID:21927823
M. Gladstone & T. T. Su. Screening for radiation sensitizers of Drosophila checkpoint mutants. Methods Mol Biol., 2011;782:105-17. PMID:21870288
A. Wichmann, L. Uyetake and T. T. Su. E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila, Dev Biol. 2010 346(1):80-9. PMID:20659447
T. T. Su. 2010. The effect of a DNA damaging agent on embryonic cell cycles of the cnidarian Hydractinia PLoS One. 2010 Jul 23;5(7):e11760. PMID:20668699
Su TT. Heterochromatin replication: better late than ever. Curr Biol. 2010 Dec 7;20(23):R1018-20. PMID:21145016
K. Garcia, J. Stumpff, T. Duncan, and T. T. Su. Tyrosines in the Kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity. Current Biology 2009 19:1670-6. PMID:19800237
M. K. Smith, W. B. Wood, W. K. Adams, C. Wieman, J. K. Knight, N. Guild, T. T. Su. Why Peer Discussion Improves Student Performance on In-Class Concept Questions. Science, 323, 122 (2009). PMID:19119232
A. Bilak and T. T. Su. Regulation of Drosophila melanogaster pro-apoptotic gene hid. APOPTOSIS. 2009 Aug;14(8):943-9. PMID:19554451
Jaklevic B, Uyetake L, Wichmann A, Bilak A, English CN, Su TT. Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. Dev Biol. 2008 Aug 1;320(1):122-30. PubMed ID:18550049
Yi X, Lemstra W, Vos MJ, Shang Y, Kampinga HH, Su TT, Sibon OC. A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress. Cytometry A. 2008 Jul;73(7):637-42. PubMed ID:18496848
Garcia K, Su TT. Cell cycle regulation. Fly (meeting report). PubMed ID:18820450
J. LaRocque, Jaklevic B, Su TT, J. Sekelsky. Drosophila ATR in double-strand break repair. Genetics. 2007 Mar;175(3):1023-33. Epub 2006 Dec 28. PubMed ID:17194776
Garcia K, Wichmann, A., Su TT. Cell cycle regulation. Fly (meeting report) 1:2, 125-131; March/April 2007. PubMed ID:19378458
Kristin Garcia, Tod Duncan and T. T. Su. Analysis of the Cell Division Cycle in Drosophila. Methods, 2007 Feb;41(2):198-205. PubMed ID:17189862
Jaklevic B, Uyetake L, Lemstra W, Chang J, Leary W, Edwards A, Vidwans SJ, Sibon O, Su TT. Contribution of Growth and Cell Cycle Checkpoints to Radiation Survival in Drosophila. (2006) Genetics. 174(4):1963-72. Epub 2006 Oct 8. PubMed ID:17028317
Wichmann, A., Jaklevic, B. and T. T. Su, Ionizing Radiation induces caspase-dependent but Chk2 and p53-independent cell death in Drosophila melanogaster. (2006) PNAS 103(26):9952-7. PubMed ID:16785441
T. T. Su. Cellular Responses to DNA Damage; One Signal, Multiple Choices. (2006) Annual Reviews in Genetics, 2006;40:187-208. PubMed ID:16805666
J. Stumpff, D. R. Kellogg, K. Krohne and T. T. Su. Drosophila Wee1 interacts with Members of -TuRC and is required for proper mitotic spindle morphogenesis and positioning. (2005) Curr Bio, 15; 1525-34. PubMed ID:16139207
A. Purdy, L. Uyetake, M. G. Cordeiro, T. T. Su. Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1). (2005) J. Cell Sci. 118: 3305-3315. PubMed ID:16079276
de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC. Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable. (2005) J Cell Sci.118:1833-42. PubMed ID:15860729
Stumpff J, Duncan T, Homola E, Campbell SD, Su TT. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. (2004) Curr Biol. 14:2143-8. PubMed ID:15589158
B. Jaklevic and T. T. Su, Relative contribution of DNA repair, cell cycle checkpoints and cell death to survival after DNA damage in Drosophila larvae. (2004) Curr. Biol., Jan 6;14(1):23-32. PubMed ID:14711410
Jaklevic B, Purdy A, Su TT. Control of mitotic entry after DNA damage in Drosophila. Methods Mol Biol. 2004;280:245-56. PubMed ID:15187258
Purdy A, Su TT. Telomeres: not all breaks are equal. Curr Biol. 2004 Aug 10;14(15):R613-4. PubMed ID:15296775
Duncan T, Su TT. Embryogenesis: coordinating cell division with gastrulation. Curr Biol. 2004 Apr 20;14(8):R305-7. PubMed ID:15084299
Patrick H. O'Farrell, Jason Stumpff and Tin Tin Su. Embryonic cleavage cycles: how is a mouse like a fly? (2004) Curr. Biol. Jan 6;14(1):R35-45. PubMed ID:14711435
Su, T.T., and Stumpff, J. (2004). Promiscuity rules? The dispensability of cyclin E and Cdk2. Sci STKE 2004, 224: pe11. PubMed ID:15026579
B. De Felice, R. R. Wilson, P. Mondola, G. Matrone, S. Damiano, C. Garbi, L. Nezi, and T. T. Su. Characterization of DIP1, a novel nuclear protein in Drosophila melanogaster. (2003) Biochemical and Biophysical Research Communications, 307:224-228. PubMed ID:12859943
A. Laurençon, A. Purdy, J. Sekelsky, R. S. Hawley and T. T. Su. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR (2003) Genetics, 164; 589-601. PubMed ID:12807779
B. Jaklevic and T. T. Su. Cell Turnover: Flexible Coupling Meets Needs of Development. (2003) Current Biology, 13:R805-7. PubMed ID:14561421
M. Garner, S. van Kreeveld and T. T. Su. mei-41 and bub1 block mitosis at two distinct steps in response to incomplete DNA replication in Drosophila embryos. (2001) Current Biology,11; 1595-1599. PubMed ID:11676920
T. T. Su, D. H. Parry, B. Donahoe, C-T. Chien, P. H. O'Farrell, A. Purdy. Cell cycle roles for two 14-3-3 proteins during Drosophila development (2001) J. Cell Science, 114; 3445-3454. PubMed ID:11682604
Su, T. T. and Jaklevic, B. DNA damage leads to a Cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula. Curr Biol 2001, 11:8-17. PubMed ID:11166174
Su, T. T. How, when and why cells get rid of Cyclin A. (2001) Current Biology, 11; R467-469. PDF here (citation missing from PubMed)
Vidwans, S. J. and Su, T. T. Cycling through development in Drosophila and other metazoa. Nature Cell. Biol. 2001. 3; E35-39. PubMed ID:11146648
Su, T. T. Walker, J, and Stumpff, J. Activating the DNA damage checkpoint in a developmental context. Curr Biol 2000 Feb 10;10(3):119-26. PubMed ID:10679321
Su, T. T. The regulation of cell growth and proliferation during organogenesis. In Vivo. 2000 Jan-Feb;14(1):141-8. PubMed ID:10757071
Su, T. T. and Vidwans S. J. DNA defects target the centrosome. Nat Cell Biol. 2000 Feb;2(2):E28-9. PubMed ID:10655600
Su, T. T. Immunoblotting of proteins from single Drosophila embryos. In 'Drosophila Protocols'. Edited by Sullivan, Ashburner and Hawley. 2000. Cold Spring Harbor Press. (book chapter, not in PubMed).
Tin Tin's papers from her post-doc with Pat O'Farrell
Su, T. T. Campbell, S. D., and O'Farrell, P. H. Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events. (1999) Current Biology, 9:919-922. PubMed ID:10469601
Su, T. T. and O'Farrell, P. H., Size control: Cell proliferation does not equal growth. (1998) Current Biology, 8:R687-R689. PubMed ID:9768354
Su, T. T. Sprenger, F., DiGregorio, P., Campbell, S. D., and O'Farrell, P. H. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. (1998) Genes & Dev., 12: 1495-1503. PubMed ID:9585509
Su, T. T. Campbell, S. D., and O'Farrell, P. H. Cell cycle program in germ cells of the Drosophila embryo, Dev. Biol., (1998) 196; 160-170. PubMed ID:9576829
Su, T. T. and O'Farrell, P. H. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. (1998) J. Cell. Biol, 140; 451-460. PubMed ID:9456309
Su, T. T. and O'Farrell, P. H. Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. (1997) J. Cell. Biol. 139; 13-21. PubMed ID:9314525
Su, T. T., Yakubovich, N. and O'Farrell, P. H. Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis. (1997) GENE, 192;283-289. PubMed ID:9224901
Su., T. T. Feger, G. and O'Farrell, P. H. Drosophila MCM protein complexes. (1996) Mol. Biol. Cell. 7; 319-329. PubMed ID:8688561
Feger G, Vaessin H, Su TT, Wolff E, Jan LY, Jan YN. dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. (1995) EMBO J. 14:5387-98. PubMed ID:7489728
Su, T. T., Follette, P. J. and O'Farrell, P. H. Qualifying for the license to replicate. (1995) Cell 81; 825-828. PubMed ID:7781058