Monica Hall

Education: B.S. Chemistry, University of Louisville, 2004

Ph.D. Genetics and Molecular Biology, Emory University, 2011

I am exploiting a novel satellite cell fate mapping approach to track nuclei into myofibers in vivo for young and aged mouse skeletal muscle. I am investigating satellite cell population heterogeneity regarding the following questions: How many times do satellite cells divide? How many progeny fuse? At what rate are myonuclei lost during homeostasis and aging? I hypothesis that alterations in satellite cell fate during aging hinders tissue homeostasis and long term maintenance of muscle. My approach also permits biological interrogation of satellite cells via retroviral-mediated gene expression, therefore, upon addressing initial questions, I will target molecular players involved in satellite cell fate. Understanding the mechanisms that control satellite cell fate would allow for the therapeutic manipulation and redirection of satellite cells to efficiently maintain skeletal muscle during aging. Before joining the Olwin Group, I was awarded a doctorate in Genetics and Molecular Biology at Emory University for my research in Dr. Grace Pavlath’s laboratory where I uncovered a role for nuclear transport receptors in regulating skeletal muscle growth. When not in the laboratory, my fiancé and I enjoy activities such as skiing, hiking and spending time with our felines and Monty, our 50 lb. Asian Water Monitor, a lizard species that is second largest by weight after the Komodo Dragon.