Publications

2023

Lee LA, Barrick SK, Meller A, Walklate J, Lotthammer JM, Tay JW, Stump WT, Bowman G, Geeves MA, Greenberg MJ, Leinwand LA. (2023) Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles. J Biol Chem 299(1):102657. PMCID: PMC9800208
Martin TG, Juarros M, Leinwand LA. (2023) Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential. Nat Rev Cardiol. PMID: 36596855. Online ahead of print.
Gotthardt M, Badillo-Lisakowski V, Parikh V, Ashley E, Fuertado M, Carmo-Fonseca M, Schudy S, Meder B, Grosch M, Steinmetz LM, Crocini C, Leinwand LA. (2023) Cardiac Splicing as a Diagnostic and Therapeutic Target. Nat Rev Cardiol. PMID: 36653465. Online ahead of print.
Meller A, Lotthammer JM, Smith LG, Novak B, Lee LA, Kuhn CC, Greenberg L, Leinwand LA, Greenberg MJ, Bowman G. (2023) Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains. Elife 12:e83602. PMCID: PMC9995120
Lee LA, Barrick SK, Buvoli AE, Walklate J, Stump WT, Geeves M, Greenberg MJ, Leinwand LA. Distinct effects of two hearing loss-associated mutations in the sarcomeric myosin MYH7b. J Biol Chem (in press)
Liang Q, Chan YC, Toscano J, Bjorkman KK, Leinwand LA, Parker R, Nesbitt DJ, Ye J. Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection. J Breath Res (in press)
Russell AJ, DuVall M, Barthel B, Qian Y, Peter AK, Stamper B, Hunt K, Schlachter S, Robertson B, Van Deusen A, Rodriguez HM, Vera C, Su Y, Claflin DR, Brooks SV, Nghiem P, Rutledge A, Patsalos A, Nagy Laszlo, Sweeney HL, Leinwand LA, Koch K. Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy. J Clin Investig (in press)

2022

Aguado BA, Walker CJ, Grim JC, Schroeder ME, Batan D, Vogt BJ, Gonzales Rodriguez A, Schwisow JA, Moulton KS, Weiss RM, Heistad DD, Leinwand LA, Anseth KS. (2022) Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts. Circulation 145(7):513-530. PMCID: PMC8844107
Lehman S, Crocini C, Leinwand LA. (2022) Targeting the sarcomere in inherited cardiomyopathies. Nat Rev Cardiol. 19(6):353-363. PMCID: PMC9119933
Magida JA, Tan Y, Wall CE, Harrison BC, Marr TG, Peter AK, Riquelme CA, Leinwand LA. (2022) Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage. J Gen Physiol. 154(4):e202113008. PMCID: PMC8958269
Muehleman D, Crocini C, Swearingen A, Ozeroff C, Leinwand LA. (2022) Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific. Am J Physiol Heart Circ Physiol. 322(5):H785-H797. PMCID: PMC8993523
Axelsson Raja A, Wakimoto H, DeLaughter D, Reichart D, Gorham J, Conner D, Probst CK, Sakai N, Knipe RS, Montesi S, Shea B, Adam LP, Leinwand LA, Wan W, Choi ES, Seidman CE, Tager AM, Seidman JG, Ho CY. (2022) Ablation of Lysophosphatidic Acid Receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. Proc Natl Acad Sci USA. 119(28): e2204174119. PMCID: PMC9282378
Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe K, Bristow M, Buttrick PM, Song K. (2022) A cardiomyocyte-specific long noncoding RNA regulates alternative splicing of the Triadin gene in the heart. Circulation 146(9):699-714. PMCID: PMC9427731
Walker CJ, Bishop C, Ramirez D, Aguado BA, Schroeder ME, Crocini C, Schwisow J, Moulton K, Macdougall L, Weiss RM, Allen MA, Dowell R, Leinwand LA, Anseth KS. (2022) Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling. Bioeng Transl Med 7(3):e10394. PMCID: PMC9472021
Tan Y, Martin TG, Harrison BC, Leinwand LA. (2022) Utility of the Burmese Python as a Model for Studying Plasticity of Extreme Physiological Systems. J Muscle Res Cell Motil. PMID: 36316565. Online ahead of print.

2021

Lakdawala N, Olivotto I, Day S, Han L, Ashley E, Michels M, Ingles J, Semsarian C, Jacoby D, Jefferies J, Colan S, Costa Pereira A, Rossano J, Wittekind S, Ware J, Saberi S, Helms S, Cirino S, Leinwand LA, Seidman C, Ho C. (2021) Associations between female sex, sarcomere variants and clinical outcomes in hypertrophic cardiomyopathy. Circ Genom Precis Med 14(1):e003062. PMID: 33284039
Johnson CA, McGreig JE, Jeanfavre ST, Walklate J, Vera CD, Mulvihill D, Baines AJ, Ridout M, Leinwand LA, Wass MN, Geeves MA. (2021) Identification of sequence changes in myosin II that adjust muscle contraction velocity. PLoS Biol 19(6):e3001248. PMCID: PMC8191873
Bjorkman K, Saldi TK, Lasda E, Bauer LC, Kovarik J, Gonzales PK, Fink MR, Tat KL, Hager CR, Davis JC, Ozeroff CD, Brisson GR, Larremore DB, Leinwand LA, McQueen MB, Parker R. (2021) Higher viral load drives infrequent severe acute respiratory syndrome coronavirus 2 transmission between asymptomatic residence hall roommates. J Infect Dis. 224(8):1316-1324. PMCID: PMC8861368
Yang Q, Meyerson NR, Clark SK, Paige CL, Fattor WT, Gilchrist AR, Barbachano-Guerrero A, Healy BG, Worden-Sapper ER, Wu SS, Muhlrad D, Decker CJ, Saldi TK, Lasda E, Gonzales PK, Fink MR, Tat KL, Hager CR, Davis JC, Ozeroff CD, Brisson GR, McQueen MB, Leinwand LA, Parker R, Sawyer SL. (2021) Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers. Elife 10:e65113. PMCID: PMC8057811
Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. (2021) Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng 5(12):1485-1499. PMCID: PMC9102466
Yang Q, Saldi TK, Lasda E, Decker CJ, Paige CL, Muhlrad D, Gonzales PK, Fink MR, Tat KL, Hager CR, Davis JC, Ozeroff CD, Meyerson NR, Clark SK, Fattor WT, Gilchrist AR, Barbachano-Guerrero A, Worden-Sapper ER, Wu SS, Brisson GR, McQueen MB, Dowell RD, Leinwand LA, Parker R, Sawyer SL. (2021) Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities. Proc Natl Acad Sci USA 118(21):e2104547118. PMCID: PMC8166196
Broadwell LJ, Smallegan MJ, Rigby KM, Navarro-Arriola JS, Montogomery RL, Rinn JL, Leinwand LA. (2021) Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart. J Biol Chem 296:100694. PMCID: PMC8141895
Peter AK, Walker CJ, Ceccato T, Trexler CL, Ozeroff CD, Lugo K, Perry AR, Anseth KS, Leinwand LA. (2021) Cardiac Fibroblasts Mediate a Sexually Dimorphic Fibrotic Response to β‐Adrenergic Stimulation. J Am Heart Assoc 10(11):e018876. PMCID: PMC8483546
Walker CJ, Schroeder ME, Aguado BA, Anseth KS, Leinwand LA. (2021) Matters of the heart: cellular sex differences. J Mol Cell Cardiol 160:42-55. PMCID: PMC8571046
Lee LA, Broadwell LJ, Buvoli M, Leinwand LA. (2021) Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. J Am Heart Assoc 10(14):e020965. PMCID: PMC8483497
Reeves K, Leibig J, Feula A, Saldi T, Lasda E, Johnson W, Lilienfeld J, Maggi J, Pulley K, Wilkerson PJ, Real B, Zak G, Davis J, Fink M, Gonzalez P, Hager C, Ozeroff C, Tat K, Alkire M, Butler C, Coe E, Darby J, Freeman N, Heuer H, Jones JR, Karr M, Key S, Maxwell K, Nelson L, Saldana E, Shea R, Salveson L, Tomlinson K, Vargas-Barriga J, Vigil B, Brisson G, Parker R, Leinwand LA, Bjorkman K, Mansfeldt C. (2021) High-resolution within-sewer SARS-CoV-2 surveillance facilitates informed intervention. Water Res 204:117613. PMCID: PMC8402945

2020

Iñigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin C, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg, EE. (2020) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15. PMCID: PMC6994285
Crocini C, Walker CJ, Anseth KS, Leinwand LA. (2020) Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness. Prog Biophys Mol Biol. 154:71-79. PMCID: PMC6864260
Bjorkman K, Guess M, Harrison B, Polmear M, Peter A, Leinwand LA. (2020) miR-206 enforces a slow muscle phenotype. J Cell Sci 133(15):jcs243162. PMCID: PMC7438006
Ceccato T, Starbuck R, Hall J, Walker CJ, Brown T, Killgore J, Anseth KS, Leinwand LA. (2020) Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment. J Am Heart Assoc 9(19):e017025. PMCID: PMC7792426

2019

Lee LA, Karabina AS, Broadwell LJ, Leinwand LA. (2019) The ancient sarcomeric myosins found in specialized muscles. Skelet. Muscle 9(1):7. PMID:30836986.
Günay KA, Ceccato TL, Silver JS, Bannister KL, Bednarski OJ, Leinwand LA, Anseth KS. (2019) PEG-Anthracene hydrogels as an on-demand stiffening matrix to study mechanobiology. Angew. Chem. 10.1002/ange.201901989. PMID: 31119851. PMC:6660351.
Vera CD, Johnson CA, Walklate J, Adhikari A, Ujfalusi Z, Svicevic M, Mijailovich S, Combs A, Langer SJ, Ruppel KM, Spudich JA, Leinwand LA, Geeves MA. (2019) Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. J Biol Chem. 294(46):17451-17462. PMID:31582565.
Johnson CA, Walklate J, Svicevic M, Mijailovich S, Vera C, Karabina A, Leinwand LA, Geeves MA. (2019) The ATPase cycle of human muscle myosin 2 isoforms: Adaptation of a single mechanochemical cycle for different physiological roles. J Biol Chem. 294(39):14267-14278. PMID: 31387944. PMC:6768639.
Muehleman D, Swearingen AR, Leinwand LA. Regression from pathological hypertrophy is sexually dimorphic and stimulus-specific. bioRxiv 678540 doi: https://doi.org/10.1101/678540
Wan W, Bjorkman K, Choi ES, Panepento A, Anseth KS, Leinwand LA. (2019) Cardiac myocytes respond differentially and synergistically to matrix stiffness and topography. bioRxiv 682930 doi: https://doi.org/10.1101/682930
Johnson CA, McGreig JE, Jeanfavre ST, Walklate J, Vera CD, Mulvihill D, Baines AJ, Ridout M, Leinwand LA, Wass MN, Geeves MA. Identification of sequence changes in myosin II that adjust muscle contraction velocity. bioRxiv 680413 doi: https://doi.org/10.1101/680413.
Peter AK, Rossi AC, Buvoli M, Ozeroff CD, Crocini C, Perry AR, Buvoli AE, Lee LA, Leinwand LA. (2019) Expression of normally repressed myosin heavy chain 7b in the mammalian heart induces dilated cardiomyopathy. J Am Heart Assoc. 8(15):e013318. PMID:31364453.
Wilson GCK, Buvoli A, Buvoli M, Woulfe KC, Walker LA, Leinwand LA. (2019) Novel model of distal myopathy caused by the myosin rod mutation R1500P disrupts acto-myosin binding. bioRxiv 760272; doi: https://doi.org/10.1101/760272.
Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan A, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. (2019) Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med 11(509). PMID:31511425. PMC:6754739.
Bjorkman K, Buvoli M, Pugach EK, Polmear MM, Leinwand LA. (2019) miR-1/206 down-regulates splicing factor Srsf9 to promote C2C12 differentiation. Skelet. Muscle 9(1):31. PMID: 31791406.
Liu Y, Afzal J, Vakrou S, Greenland GV, Talbot CC, Hebl VG, Guan Y, Karmali R, Tardiff JC, Leinwand LA, Olgin JE, Das S, Fukunaga R, Abraham MR. (2019) Differences in miR29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy. Front Cardiovasc Med, 6:170. PMCID: PMC6928121.

2018

Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Dilated cardiomyopathy myosin mutants have reduced force-generating capacity. (2018) J Biol Chem. 293(23):9017-9029. PMID: 29666183
Chung E, Haizlip KM, Leinwand LA. Pregnancy late in rodent life has detrimental effects on the heart. (2018) Am J Physiol Heart Circ Physiol. PMID: 29750565.
Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. (2018) JCI Insight. 3(6). pii: 94493. PMID: 29563334

2017

Luckey SW, Haines C, Konhilas JP, Luczak E, Messmer-Kratzsch A, Leinwand LA. Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy. (2017) Exp Biol Med (Maywood). 1535370217731503. PMID: 28901173.
Trexler CL, Odell AT, Jeong MY, Dowell RD, Leinwand LA. Transcriptome and functional profile of cardiac myocytes is influenced by biological sex. (2017) Circ Cardiovasc Genet. 5, pii: 3001770. PMID:29030402.
Peter AK, Crocini C, Leinwand LA. Expanding our scientific horizons: utilization of unique model organisms in biological research. (2017) EMBO J. 36(16):2311-2314. PMID:28694243.
Wan W, Leinwand LA. Computational approach to measuring myocyte disarray in animal models of heart disease. (2017) Curr Protoc Hum Genet. 93:15.11, 1-15. PMID:28384401.
Vega RB, Konhilas JP, Kelly DP, Leinwand LA. Molecular mechanisms underlying cardiac adaptation to exercise. (2017) Cell Metab. 25(5):1012-1026. PMID:28467921.
Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthels KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. (2017) J Endocrinol. 232(3):475-491. PMID:28053000.

2016

Schiaffino S, Murgia M, Leinwand LA, Reggiani C. Letter to the editor: Comments on Stuart et al. (2016): “Myosin content of individual human muscle fibers isolated by laser capture microdissection”. (2016) Am J Physiol Cell Physiol. 311(6):C1048-C1049. PMID:27956413.
Peter A, Bjerke M, Leinwand LA. Biology of the Cardiac Myocyte in Heart Disease. (2016) Mol. Biol. of the Cell. 27(14):2149-60. PMID: 27418636.
Feinstein-Linial M, Buvoli M, Buvoli A, Sadeh M, Dabby R, Dayan D, Leinwand LA, Birk O. Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture. (2016) BMC Medical Genetics. 17(1):57. PMID:27519903.
Pugach E, Blenck C, Dragavon JM, Langer SL, Leinwand LA. Estrogen receptor profiling and activity in cardiac myocytes. (2016) Mol Cell Endocrinol S0303-7207(16)30153-8. PMID:27164442.
Walklate J, Vera C, Bloemink M, Geeves MA, Leinwand LA. The most prevalent Freeman-Sheldon Syndrome mutations in human embryonic myosin motor share functional defects. (2016) J. Biol. Chem. 291:10318-31.
Blenck C, Harvey P, Reckelhoff JF, Leinwand LA. (2016) The importance of biological sex and estrogen in rodent models of cardiovascular health and disease. Cir Res 2016 118(8):1294-312. PMID:2708111
Green EM, Wakimoto H, Anderson RL, Evanchik M, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE. (2016) A small molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science 351:617-21. PMID:26912705.

2015

Nag S, Sommese R, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel K, Spudich^,JA. (2015) Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Science Advances. 1(9):e1500511, PMID: 26601291.
Pugach EK, Richmond PA, Azofeifa JG, Dowell RD, Leinwand LA. (2015) Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic. J Mol. Cell. Cardiol. 86:54-61. PMID: 26141530.
Taylor K, Buvoli M, Korkmaz E, Buvoli A, Zheng Y, Heinze N, Cui Q, Leinwand LA, Rayment I. (2015) Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc. Natl. Acad. Sci. USA 112 (29), PMID: 26150528.
Schiaffino S, Rossi A, Smerdu V, Leinwand LA, Reggiani C. (2015) Developmental myosins: expression patterns and functional significance. Skel. Muscle 15; 5:22. PMID: 26180627.
Hajj GP, Lund DD, Chu Y, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Doshi H, Leinwand LA, Heistad D, Weiss RM. (2015) Spontaneous aortic regurgitation and valvular cardiomyopathy in mice. Arter.Thromb. Vasc. Biol. 35(7):1653-62. PMID: 25997932.
Guess MG, Barthel KKB, Harrison BC, Leinwand LA. (2015) miR-30 family microRNAs regulate myogenesis and provide negative feedback on the microRNA pathway. PLoS One. 17; 10(2):e0118229. PMID: 25689854.
Harvey P, Leinwand LA. (2015) Estrogen enhances cardiotoxicity induced by Sunitnib by regulation of drug transport and metabolism. Cardiovascular Research 107(1):66-77. PMID: 26009590.
Konhilas J, Chen H, Luczak E, McKee L, Regan J, Watson P, Stauffer B, Khalpey Z, McKinsey T, Horn T, LaFleur B, Leinwand LA. (2015) Diet and sex modify exercise and cardiac adaptation in the mouse. Am. J. Physiol. Heart Circ. Physiol. 308(2):H135-45. PMID: 25398983.

2014

Wang H, Leinwand LA, Anseth KS. (2014) Cardiac valve cells and their microenvironment-insights from in vitro studies. Nature Reviews Cardiology 11(12):715-27. PMID: 25311230.
Haizlip K, Harrison B, Leinwand LA. (2015) Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology. 30(1):30-9. PMID: 25559153.
Harvey, P.A., Wall, C., Luckey, S.W., Langer, S. and Leinwand, L.A. (2014) The Python Project: a unique model for extending research opportunities to undergraduate students. CBE – Life Sciences Education. 13 (4):698-710. PMID: 25452492.
Harvey PA, Leinwand LA. (2015) Dietary phytoestrogens present in soy dramatically increase cardiotoxicity in male mice receiving a chemotherapeutic tyrosine kinase inhibitor. Mol. Cell. Endocrinol. 399:330-5. PMID: 25458703.
Wang H, Leinwand LA, Anseth KS. (2014) Roles of TGF-β1 and OB-cadherin in cardiac valve myofibroblast differentiation. FASEB J. 2014 Oct;28(10):4551-62, PMID: 25008089.
Burns K, Byrne B, Gelb B, Kuhn B, Leinwand LA, Mital S, Pearson G, Rodefeld M, Rossano J, Stauffer, B., Taylor, M., Towbin, J. and A. Redington. (2014) New Mechanistic and Therapeutic Targets for Pediatric Heart Failure: Report from a National Heart, Lung, and Blood Institute Working Group. Circulation. 130(1):79-86. PMID:24982119
Magida JA, Leinwand LA. (2014) Metabolic crosstalk between heart and liver impacts familial hypertrophic cardiomyopathy. EMBO Mol. Med. 6(4):482-95. PMCID:24567073.
Chung E, Leinwand LA. (2014) Pregnancy as a cardiac stress model. Cardiovascular Research. 101(4):561-70. PMCID:24448313.
Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand LA, Geeves MA. (2014) The hypertrophic cardiomyopathy myosin mutation R453C alters ATP-binding and hydrolysis of human cardiac β-myosin. J. Biol. Chem. 289(8):5158-67. PMID: 24344137.

2013

Wang H, Tibbitt MW, Langer SJ, Leinwand LA, Anseth KS. (2013) Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway. Proc. Natl. Acad. Sci. 110(48):19336-41. PMCID:24218588.
Harvey PA, Leinwand LA. (2013) Cardiac atrophy and remodeling. In: Cellular and Molecular Pathobiology of Cardiovascular Disease. M.S. Willis, J.W. Homeister and J.R. Stone (Eds), Elsevier. 3:37-50.
Kucherlapati R, Leinwand LA. (2013) Frank Ruddle (1929-2013). Am J Hum Genet. 92(6):839-40. PMCID:PMC3675234
Barthel KBB, Harvey PA, Leinwand LA. (2013) Diet and Exercise Are Potent Modulators of Cardiovascular Disease in Women. In E.E. Spangenburg (Ed.), Integrative Biology of Women's Health. 10:175-204.
Wang H, Sridhar B, Leinwand LA, Anseth KS. (2013) Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves. PLoS ONE. 8(7):e69667. doi: 10.1371/journal.pone.0069667. PMCID:PMC3720586.
Bloemink MJ, Deacon JC, Resnicow DI, Leinwand LA, Geeves MA. (2013) The superfast human extra-ocular myosin is kinetically distinct from the fast skeletal IIa, IIb and IId isoforms. J. Biol. Chem. 288:27469-79. PMID:23908353.
Chung E, Yeung F, Leinwand LA. (2013) Calcineurin activity is required for cardiac remodeling in pregnancy. Cardiovascular Research. 100(3):402-10. PMCID: PMC3826703.
Sommese RF, Sung J, Nag S, Sutton S, Deacon J, Choe E, Leinwand LA, Ruppel K, Spudich JA. (2013) Molecular consequences of the R453C hypertrophic cardiomyopathy mutation. Proc. Natl. Acad. Sci. 110(31):12607-12. PMCID:PMC3732973.
Guess MG, Barthel KKB, Pugach EK, Leinwand LA. (2013) Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging. Skeletal Muscle. 3(1):19 doi:10.1186/2044-5040-3-19. PMCID:PMC3750807.
Harrison BC, Leinwand LA. (2013) Invited Review. Young at heart: GDF11 reverses age-related cardiac hypertrophy. Cell. 53(4):743-5. PMID:23663775.
Xu R, Andres-Mateos E, Majias R, MacDonald EM, Leinwand LA, Merriman DK, Fink RHA, Cohn RD. (2013) Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Experimental Neurology. 247:392-401. PMCID:PMC3706566.
Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Hedderick EF, Marr TG, Lin BM, Hourde C, Leinwand LA, Kuhl D, Föller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD. (2013) Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostatis and prevent atrophy. EMBO Mol Med. 5(1):80-91. PMCID:PMC3569655.

2012

Ruas JL, White JP, Brannan KT, Harrison B, Greene NP, Wu J, Kleiner S, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM. (2012) A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151(6):1319-31. PMCID:PMC3520615.
Andres-Mateos E, Majias R, Soleimani A, Lin BM, Burks TN, Marx R, Lin B, Zellars RC, Zhang Y, Huso DL, Marr TG, Leinwand LA, Merriman DK, Cohn RD. (2012) Imparied skeletal muscle regeneration in the absence of figrosis during hibernation in 13-lined ground squirrels. PLoS ONE 7(11):348884. PMCID:PMC3498346.
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. (2012) The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 492(7428):285-9. PMCID:PMC3521872.

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