Postdoctoral Research Associate

M.D./Ph.D., University of Pavia, Italy, 1983, 1989

In the past years my research has been primarily focused on the myosin structural determinants that guide myosin assembly into the sacomere, as well as on the pathological effects of β-myosin mutations causing cardiac and skeletal myopathies. I primarily use live-cell imaging to study the proper incorporation of WT and mutant fluorescent myosin molecules into the sarcomere, monitor their trafficking, and determine their turnover in cardiac cells. Moreover, I study the structure-function relationship of myosin in collaboration with Dr. Ivan Rayment  (University of Wisconsin)