Selected Publications:

Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates.

Stengel G, Kuchta RD.

J Virol. 2011 Jan;85(2):957-67.

Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.

Urban M, Joubert N, Purse BW, Hocek M, Kuchta RD.

Biochemistry. 2010 Feb 2;49(4):727-35

High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo.

Stengel G, Urban M, Purse BW, Kuchta RD.

Anal Chem. 2009 Nov 1;81(21):9079-85.

Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation.

Cavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RD.

Biochemistry. 2009 Nov 3;48(43):10199-207.

Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha.

Cavanaugh NA, Kuchta RD.

J Biol Chem. 2009 Jan 16;284(3):1523-32.

Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.

Beckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RD.

Biochemistry. 2007 Jan 16;46(2):448-