Solvent Guides

The following references should be available to affiliates of the Unversity of Colorado Boulder when accessed on the UCB wireless network. For individuals at other institutions, many of these should be available through your own organization's subscription to online journals. 

American Chemical Society Solvent Selection Tool

Developed by the ACS GCI Pharmaceutical Roundtable, this Solvent Selection Tool allows you to select solvents based on their physical properties

MIT "Green" Alternatives Wizard

Search for a chemical to replace, a process to replace, an alternative chemical, or an alternative process using the Massachusetts Institute of Technology Green Alternatives Wizard.

General Green Solvent Information

Capello, Christian, Ulrich Fischer, and Konrad Hungerbuhler. “What is a green solvent? A comprehensive framework for the environmental assessment of solvents.” Green Chemistry 9 (2007): 927-934. Web. DOI: 10.1039/B617536H

Jessop, Philip G. “Searching for green solvents.” Green Chemistry 13 (2011): 1391-1398. Web. DOI: 10.1039/c0gc00797h

Solvent Guides

Alfonsi, Kim. et. al. “Green chemistry tools to influence a medicinal chemistry and research chemistry based organization.” Green Chemistry 10 (2008): 31-36. Web. DOI: 10.1039/b711717e

American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable Solvent Selection Guide Version 2.0 issued March 21, 2011. https://www.acs.org/content/dam/acsorg/greenchemistry/industriainnovatio...

Henderson, Richard K. et. al. “Expanding GSK’s solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry.” Green Chemistry 13 (2011): 854-862. Web. DOI: 10.1039/c0gc00918k

MacMillan, Donna S. et. al. “Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide.” Green Chemistry 15 (2013): 596-600. Web. DOI: 10.1039/c2gc36900a

McGonagle, Fiona I. et. al. “Development of a solvent selection guide for aldehyde-based direct reductive amination processes.” Green Chemistry 15 (2013): 1159-1165. Web. DOI: 10.1039/c3gc40359a

Prat, Denis, et. al. "CHEM21 selection guide of classical- and less classical-solvents." Green Chemistry 18 (2016) 288-296. Web. DOI: 10.1039/c5gc01008j

Prat, Denis, et. al. “Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes.” Organic Process Research & Development 17 (2013): 1517-1525. Web. DOI: 10.1021/op4002565