LaRocca TJ, Mariani A, Watkins LR, Link CD. (2019) TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes. Neurobiol Dis. Jun 21;132:104514. doi: 10.1016
Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V. α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease. (2019) Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8895-8900. doi: 10.1073/pnas.1820585116. Epub 2019 Apr 19.
Saldi TK, Gonzales PK, LaRocca TJ, Link CD (2019) Neurodegeneration, Heterochromatin, and Double-Stranded RNA. J. Experimental Neuroscience Feb 14;13:1179069519830697. doi: 10.1177/1179069519830697
Guerrero-Gómez D, Mora-Lorca JA, Sáenz-Narciso B, Naranjo-Galindo FJ, Muñoz-Lobato F, Parrado-Fernández C, Goikolea J, Cedazo-Minguez Á, Link CD, Neri C, Sequedo MD, Vázquez-Manrique RP, Fernández-Suárez E, Goder V, Pané R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A. (2019) Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation. Cell Death Differ. Feb 15. doi: 10.1038/s41418-018-0270-9.
Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. (2019) Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.
Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD. (2018) In vivo induction of membrane damage by β-amyloid peptide oligomers.
Acta Neuropathol Commun. Nov 29;6(1):131. doi: 10.1186/s40478-018-0634-x.
Gonzales PK, Roberts CM, Fonte V, Jacobsen C, Stein GH, Link CD. (2018) Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21. PLoS One. Mar 27;13(3):e0194581. doi: 10.1371
Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD. (2018) The C. elegans ortholog of TDP-43 regulates the chromatin localization of the heterochromatin protein 1 homolog, HPL-2. Mol Cell Biol. May 14. pii: MCB.00668-17. doi: 10.1128
Van Treeck B, Protter DSW, Matheny T, Khong A, Link CD, Parker R. (2018) RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2734-2739. doi: 10.1073/pnas.1800038115
Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD. (2017) Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Hum Mol Genet Jun 16. Sep 1;26(17):3421-3431
Henze A, Homann T, Rohn I, Aschner M, Link CD, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J. (2016) Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin. Sci Rep. 6:37346. doi: 10.1038/srep37346.
Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD. (2016) Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 353(6300):708-12. doi:10.1126/science.aaf7791.
Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL. (2016) DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. (2016) PLoS Genet. 12(7):e1006133. doi: 10.1371/journal.pgen.1006133.
Kokona B, May CA, Cunningham NR, Richmond L, Jay Garcia F, Durante JC, Ulrich KM, Roberts CM, Link CD, Stafford WF, Laue TM, Fairman R. (2016) Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection. Protein Sci. (3):605-17. doi: 10.1002/pro.2854.
Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. (2016) C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience 19(5):668-677
Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, Baker MC, Perkerson RB, van Blitterswijk M, Stetler CT, Rademakers R, Link CD, Dickson DW, Boylan KB, Li H, Petrucelli L. (2015) Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. Nature Neuroscience 18(8):1175-82.
Saldi TK, Ash PEA, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. (2014) TDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J Dec 17;33(24):2947-66.
Hassan WM, Dostal V, Yerg JE, Link CD. Identifying Ab-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. (2014) Neurobiology of Aging Feb;36(2):857-66.
Machino K, Link CD, Wang S, Murakami H, Murakami S. (2014) A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons. Front Genet. Jul 4;5:202. doi: 10.3389
Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shepard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A. (2013) Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases. Antioxid Redox Signal. Jan 10;20(2):217-35.
Lublin, AL and Link, CD. Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity. (2013) Drug Discov Today Technol. Spring;10(1):e115-9. doi: 10.1016/j.ddtec.2012.02.002
Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. (2012) Progranulin regulates neuronal outgrowth independent of sortilin. Mol Neurodegener.. Jul 10;7:33
Cacho-Valadez B, Muñoz-Lobato F, Pedrajas JR, Cabello J, Fierro-González JC, Navas P, Swoboda P, Link C. D, Miranda-Vizuete A. (2012) The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity. Antioxid Redox Signal. Jun 15;16(12):1384-400.
Link C. D, Saldi T. K. Cell death by glutamine repeats? (2012) Science. Feb 24;335(6071):926-7.
Cotella D, Hernandez-Enriquez B, Wu X, Li R, Pan Z, Leveille J, Link C.D., Oddo S, Sesti F. (2012) Toxic role of K+ channel oxidation in mammalian brain.
J Neurosci. Mar 21;32(12):4133-44
Fonte V., Dostal V., Roberts C.M., Gonzales P., Lacor P., Magrane J., Dingwell N., Fan E.Y., Silverman M.A., Stein G.H., Link C.D. (2011) A glycine zipper motif mediates the formation of toxic b-amyloid oligomers in vitro and in vivo. Mol Neurodegener. 2011 Aug 23;6(1):61.
Mendenhall A.R., Wu D., Park S.K., Cypser JR, Tedesco PM, Link C.D., Phillips P.C., Johnson T.E. (2011) Genetic dissection of late-life fertility in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. Aug;66(8):842-54.
McColl, G., Rogers, A.N., Alavez, S., Hubbard, A.E., Melov, S., Link, C.D., Bush, A.I., Kapahi, P., Lithgow, G.J. (2010) Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans. Cell Metab;12(3):260-72.
Ash, P.E., Zhang, Y.J., Roberts, C.M., Saldi, T., Hutter. H., Buratti, E., Petrucelli, L., Link, C.D. (2010) Neurotoxic effects of TDP-43 overexpression in C. elegans Hum Mol Genet. 2010 Aug 15;19(16):3206-18.
Dostal, V. and Link C.D. (2010) Assaying b-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. Oct 9;(44).
Dostal, V., Roberts, C.M., Link, C.D. (2010) Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of b-amyloid Peptide Toxicity. Genetics Nov;186(3):857-66.
Dosanjh, L.E., Brown, M. K., Rao, G, Link C. D., Luo Y. (2010) Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta. J Alzheimers Dis. 19(2):681-90
Teschendorf, D. and Link, C. D. (2009) What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Molecular Neurodegeneration Sept 28;4(1):38
Park S. K., Link C. D., Johnson T. E. (2009) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. Feb;24(2):383-92.
Hassan, W. M., Merin, D. A., Fonte V., Link, C. D. (2009) AIP-1 ameliorates b-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum Mol Genet. Aug 1;18(15):2739-47.
Zhang, Y. J., Xu Y. .F, Cook, C., Gendron, T. F., Roettges, P., Link, C. D., Lin, W. L., Tong, J., Castanedes-Casey, M., Ash, P., Gass, J., Rangachari, V., Buratti, E., Baralle, F., Golde, T. E., Dickson, D. W., Petrucelli, L. (2009) Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc Natl Acad Sci U S A. May 5;106(18):7607-12.
Link, C.D., Fonte, V., Roberts C.M., Hiester, B., Silverman, M.A., Stein. G. (2008) The b amyloid peptide can act as a modular aggregation domain. Neurobiology of Disease,32(3):420-5
Fonte V., Kipp D.R., Yerg J., Merin D., Forrestal M., Wagner E., Link C.D. (2008) Suppression of in vivo b amyloid peptide toxicity by overexpression of the HSP-16 small chaperone protein. J Biol Chem. 283(2):784-91
Florez-McClure M.L., Fonte G., Hohsfield L., Bealor M., Link C.D. (2007) Decreased insulin signaling promotes the autophagic degradation of b-amyloid peptide in C. elegans. Autophagy 3(6):569-80.
Wu Y., Wu Z., Butko P., Christeen Y., Lambert, M.P., Klein W.L., Link C.D., Luo Y. (2006) Ab-induced pathological behaviors are suppressed by Ginkgo biloba extract and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci. 26(50):13102-13.
Link C.D., (2006) C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol. 41(10):1007-13.
Link C.D., Fonte V., Hiester B., Yerg J., Ferguson J., Csontos S., Silverman MA., Stein G. H. (2006) Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide. J Biol Chem. Jan 20;281(3):1808-16
Boyd-Kimball D, Poon HF, Lynn BC, Cai J, Pierce Jr WM, Klein JB, Ferguson J, Link CD, Butterfield DA. (2006) Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): Implications for Alzheimer's disease. Neurobiol Aging. 27(9):1239-49
Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. (2005) A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 58(2):277-89.
Link, C.D. (2005). Invertebrate models of Alzheimer’s Disease. Genes, Brain and Behavior, 4(3):147-56.
Gutierrez-Zepeda A, Santell R, Wu Z, Brwon M, Wu Y, Khan I, Link CD, Zhao B, Luo Y. (2005) Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci. 6(1):54.
Kapulkin V., Hiester B. G., Link C. D. (2005) Compensatory regulation among ER chaperones in C. elegans.
FEBS Lett. 579(14):3063-8.
Strayer, A., Wu, Z., Christen, Y., Link. C.D., & Luo, Y. (2003). Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginko biloba extract EGb761. FASEB J, 17, 2305-2307.
Drake J., Link C.D., Butterfield D.A. (2003) Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging 24:415-420.
Kampkotter A., Volkmann T.E., de Castro S.H., Leiers B., Klotz L.O., Johnson T.E., Link C.D., Henkle-Duhrsen K. (2003) Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans. J Mol Biol 325:25-37.
Leiers B., Kampkotter A., Grevelding C.G., Link C.D., Johnson T.E., Henkle-Duhrsen K. (2003) A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic Biol Med 34:1405-1415.
Link C.D., Taft A., Kapulkin V., Duke K., Kim S., Fei Q., Wood D.E., Sahagan B.G. (2003) Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging 24:397-413.
Strayer A., Wu Z., Christen Y., Link C.D., Luo Y. (2003) Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. Faseb J 17:2305-2307.
Borgonie G., Link C.D., Claeys M., Coomans A. (2003) Lysosomal and pseudocoelom routing protects Caenorhabditis elegans from ricin toxicity. Nematology 5: 339-350
Blumenthal T., Evans D., Link C.D., Guffanti A., Lawson D., Thierry-Mieg J., Thierry-Mieg D., Chiu W.L., Duke K., Kiraly M., Kim S.K. (2002) A global analysis of Caenorhabditis elegans operons. Nature 417:851-854.
Fonte V., Kapulkin V., Taft A., Fluet A., Friedman D., Link C.D. (2002) Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc Natl Acad Sci U S A 99:9439-9444.
GuhaThakurta D., Palomar L., Stormo G.D., Tedesco P., Johnson T.E., Walker D.W., Lithgow G., Kim S., Link C.D. (2002) Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res 12:701-712.
Link C.D., Johnson C.J. (2002) Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol 353:497-505.
Johnson T.E., Henderson S., Murakami S., de Castro E., de Castro S.H., Cypser J., Rikke B., Tedesco P, Link C.D, (2002) Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. Journal of Inherited Metabolic Disease 25: 197-206
Link C.D. (2001) Transgenic invertebrate models of age-associated neurodegenerative diseases. Mech Ageing Dev 122:1639-1649.
Link C.D., Johnson C.J., Fonte V., Paupard M., Hall D.H., Styren S., Mathis C.A., Klunk W.E. (2001) Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 22:217-226.
Johnson T.E., Cypser J., de Castro E., de Castro S., Henderson S., Murakami S., Rikke B., Tedesco P., Link C.D. (2000) Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Experimental Gerontology 35: 687-694
Butterfield D.A., Yatin S.M., Link C.D. (1999) In vitro and in vivo protein oxidation induced by Alzheimer's disease amyloid beta-peptide (1-42). Ann N Y Acad Sci 893:265-268.
Link C.D., Cypser J.R., Johnson C.J., Johnson T.E. (1999) Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell Stress Chaperones 4:235-242.
Yatin S.M., Varadarajan S., Link C.D., Butterfield D.A. (1999) In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42). Neurobiol Aging 20:325-330; discussion 339-342.
Fay D.S., Fluet A., Johnson C.J., Link C.D. (1998) In vivo aggregation of beta-amyloid peptide variants. J Neurochem 71:1616-1625.
Silverman, M., M. L. Blaxter and Link C.D. (1997). "Biochemical analysis of Caenorhabditis elegans surface mutants." Journal of
Nematology 29: 296-305.
Link C.D. (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A 92:9368-9372.
Borgonie G., van Driessche E., Link C.D., de Waele D., Coomans A. (1994) Tissue treatment for whole mount internal lectin staining in the nematodes Caenorhabditis elegans, Panagrolaimus superbus and Acrobeloides maximus. Histochemistry 101:379-384.
Link C.D., Silverman M.A., Breen M., Watt K.E., Dames S.A. (1992) Characterization of Caenorhabditis elegans lectin-binding mutants. Genetics 131:867-881.
Link C.D., Ehrenfels C.W., Wood W.B. (1988) Mutant expression of male copulatory bursa surface markers in Caenorhabditis elegans. Development 103:485-495.
Link C.D., Graf-Whitsel J., Wood W.B. (1987) Isolation and characterization of a nematode transposable element from Panagrellus redivivus. Proc Natl Acad Sci U S A 84:5325-5329.
Link C.D., Reiner A.M. (1983) Genotypic exclusion: a novel relationship between the ribitol-arabitol and galactitol genes of E. coli. Mol Gen Genet 189:337-339.
Link C.D., Reiner A.M. (1982) Inverted repeats surround the ribitol-arabitol genes of E. coli C. Nature 298:94-96.
Beam C.A., Himes M., Himelfarb J., Link C.D., Shaw K. (1977) Genetic evidence of unusual meiosis in the dinoflagellate Crypthecodinium cohnii. Genetics 87:19-32