Publications

  • 131) Dohrmann, P.R., Yuan, Q, , Sutton, M.D., and McHenry, C.S. (2016) DNA Polymerase III, but not Polymerase IV, Must be Bound to tau-Containing DnaX Complex to Enable Exchange into Progressing Replication Forks. J. Biol. Chem. 291, 11727-11735.
  • 130) Dohrmann, P.R., Correa, R., Frisch R.L., Rosenberg, S.M., McHenry, C.S. (2016) “The DNA polymerase III holoenzyme contains gamma and is not a trimeric polymerase.” Nucl. Acids Res. 44, 1285-1297.
  • 129) Lindow, J.C., Dohrmann, P.R., McHenry, C.S. (2015) “DNA Polymerase alpha Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Screen” J. Biol. Chem. 290, 16851-16860J. Biol. Chem. 290, 16851-16860.  
  • 128) Manhart, C.M., McHenry, C.S. (2015) “Identification of Subunit Binding Positions on a Model Fork and Displacements that Occur During Sequential Assembly of the E. coli Primosome.” J. Biol. Chem. 290, 10828-10839.
  • 127) McHenry, C.S. (2014) “Chemical biology of DNA replication.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.) Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_133-1.
  • 126) McHenry, C.S. (2014) “Many Bacteria use a Special Mutagenic Pol III in Place of Pol V.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.)Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_124-1.
  • 125) McHenry, C.S. (2014) “DnaX Complex Composition and Assembly within Cells.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.) Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_123-1.
  • 124) McHenry, C.S. (2014) “Cycling of the Lagging Strand Replicase During Okazaki Fragment Synthesis.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.) Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_132-1
  • 123) McHenry, C.S. (2014) “DNA Polymerase III Structure.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.) Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_131-1.
  • 122) McHenry, C.S. (2014)“Mechanism of Initiation Complex Formation.” In: Bell E, Bond J, Klinman J, Masters B, Wells R (eds.)  Molecular life sciences: an encyclopedic reference. Springer Science+Business Media New York. DOI: 10.1007/978-1-4614-6436-5_128-1.
  • 121) Yuan, Q. and McHenry, C. (2014) Cycling of the E. coli lagging strand polymerase is triggered exclusively by the availability of a new primer at the replication fork. Nucleic Acids Res42, 1747-1756.
  • 120) Antony, E., Weiland, E., Yuan, Q., Manhart, C.M., Nguyen, B., Kozlov, A.G., McHenry, C. and Lohmman, T.M. (2013) Multiple C-Terminal Tails within a Single E. coli SSB Homotetramer Coordinate DNA Replication and Repair. J. Mol. Biol.  425, 4802-4819.
  • 119) Ungermannova D., Lee J., Zhang G., Dallmann H.G., McHenry C. and Liu X. (2013) High-Throughput Screening Alpha Screen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCFSkp2-Cks1. J. Biomol Screen., 8, 910-20.
  • 118) Seco, E., Zinder, J., Manhart, C.M., Piano, A.L., McHenry, C. and Ayora, S. (2013) Bacteriophage SPP1 in vitro DNA Replication Strategies Promote Viral and Disable Host Replication.  Nucleic Acid Res., 41, 1711-1721.
  • 117) Manhart, C.M. and McHenry, C. (2013) The PriA Replication Restart Protein Blocks Replicase Access Prior to Helicase Assembly and Directs Template Specificity through its ATPase Activity.  J. Biol. Chem., 288, 3989-3999.
  • 116) McHenry, C. Bacterial DNA Replicases.  E. Bell, J. Bond, J. Klinman, B. Siler Masters, and R. Wells (Eds.),Molecular Life Sciences: An Encyclopedic Reference. Springer Science+Business Media, New York. DOI: 10.1007/978-1-4614-6436-5_54-2. 
  • 115) Dohrmann, P.R., Manhart, C.M., Downey, C.D. and McHenry, C. (2011) The Rate of Polymerase Release upon Filling the Gap between Okazaki Fragments is Inadequate to Support Cycling During Lagging Strand Synthesis.  J. Mol. Biol.414,15-27.
  • 114) McHenry, C. (2011) Bacterial Replicases and Related Polymerases.  Curr.Opin.Chem. Biol.15, 587-594.
  • 113) Downey, C.D., Crooke, E. and McHenry, C. (2011) Polymerase Chaperoning and Multiple ATPase Sites Enable the E. coli DNA Polymerase III Holoenzyme to Rapidly Form Initiation Complexes.  J. Mol. Biol., 412, 340-353.
  • 112) McHenry, C. (2011)  Breaking the Rules: Bacteria That Use Several DNA Polymerase IIIs. EMBO Rep12, 408-414.
  • 111) McHenry, C. (2011) DNA Replicases from a Bacterial Perspective.  Annu. Rev. Biochem., 80, 403-436.
  • 110) Wieczorek, .A, Downey, C.D., Dallmann, H.G. and McHenry, C. (2010) Only one ATP-binding DnaX Subunit is Required for Initiation Complex Formation by the Escherichia coli DNA Polymerase III Holoenzyme.  J. Biol. Chem., 285, 29049-29053.
  • 109) Dallmann, H.G.,Fackelmayer, O.J., Tomer, G., Chen, J.Y., Wiktor-Becker, A., Ferrara, T., Pope, C., Oliveira, M.T., Burgers, P.M.J., Kaguni, L.K. and McHenry, C. (2010) Parallel Multiplicative Target Screening Against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential. Biochemistry49, 2551-2562.
  • 108) Downey, C.D. and McHenry, C. (2010) Chaperoning of a Replicative Polymerase onto a Newly-Assembled DNA Bound Sliding Clamp by the Clamp Loader. Mol. Cell37,481-491.
  • 107) Sanders, G.M., Dallmann, H.G. and McHenry, C. (2010) Reconstitution of the B. subtilis Replisome with 13 Proteins including Two Distinct Replicases.  Mol. Cell37, 273-281.
  • 106) Yuan,Q. and McHenry, C. (2009) Strand Displacement by DNA Polymerase III Occurs through a tau-psi-chi Link to SSB Coating the Lagging Strand Template.  J. Biol. Chem., 284, 31672-31679.
  • 105) Guiles, J., Sun, X., Critchley, I.A., Ochsner, U., Tregay, M., Stone, K., Bertino, J., Green, L., Sabin, R., Dean, F., Dallmann, H.G., McHenry, C. and Janic, N. (2009) Quinazolin-2-ylamino-quinazolin-4-ols as Novel Non-nucleoside Inhibitors of Bacterial DNA Polymerase III.  Bioorg Med Chem Lett., 19, 800-802.
  • 104) Stano, N., Chen, J. and McHenry, C. (2006) A Coproofreading Zn+2-dependent Exonuclease within a Bacterial Replicase.  Nat. Struct. Mol. Biol.,13, 458-459.
  • 103) Wieczorek, A. and McHenry, C. (2006) The N-terminal php Domain of the alpha Subunit of the E. coli Replicase Binds the epsilon Proofreading Subunit.  J. Biol. Chem., 281, 12561-12567.
  • 102) Jarvis, T.C., Beaudry, A.A., Bullard, J.M., Ochsner, U., Dallmann, H.G. and McHenry, C., (2005) Discovery and Characterization of the Cryptic gamma Subunit of the Pseudomonad DNA Replicase.  J. Biol. Chem., 280, 40465-40473.
  • 101) Dohrmann, P.R. and McHenry, C., (2005) A Bipartite Polymerase–Processivity Factor Interaction: Only the Internal beta Binding Site of the alpha Subunit is Required for Processive Replication by the DNA Polymerase III Holoenzyme.   J. Mol. Biol., 350, 228-239.
  • 100) Jarvis, T.C., Beaudry, A.A., Bullard, J.M., Janjic, N. and McHenry, C. (2005) Reconstitution of a minimal DNA Replicase from Pseudomonas aeruginosa and Stimulation by Non-cognate Auxiliary Factors.  J. Biol Chem., 280, 7890-7900.
  • 99)  McHenry, C. (2003) Chromosomal Replicases as Asymmetric Dimers: Studies of Subunit Arrangement and Functional Consequences.  Mol. Microbiol., 49, 1157-1165.
  • 98)  Bullard J.M., Williams J.C., Acker W.K., Jacobi C,. Janjic N. and McHenry C. (2002) DNA Polymerase III Holoenzyme from Thermus thermophilus: Identification, Expression, Purification of Components and Use to Reconstitute a Processive Replicase.  J. Biol. Chem., 277, 13401-13408.
  • 97)  Bullard, J., Pritchard, A., Song, M.-S., Glover, B., Wieczorek, A., Chen, J., Janjic, N. and McHenry, C. (2002)  A Three Domain Structure for the delta Subunit of the DNA Polymerase III Holoenzyme delta Domain III Binds delta' and Assembles into the DnaX Complex.   J. Biol. Chem., 277, 13246-13256.
  • 96)  Muthuswami, R., Chen, J., Burnett, B., Thimmig, R., Janjic, N. and McHenry, C. (2002) The HIV Plus-Strand Transfer Reaction: Determination of Replication-Competent Intermediates and Identification of a Novel Lentiviral Element, the Primer Over-Extension Sequence.  J. Mol. Biol., 315, 311-323.
  • 95)  Song, M-S. and McHenry, C. (2001)  Carboxyl-terminal Domain III of the delta' Subunit of DNA Polymerase III Holoenzyme Binds DnaX and Supports Cooperative DnaX-Complex Assembly.   J. Biol. Chem., 276, 48709-48715.
  • 94)  Duan, C., Poticha, D., Stoeckli, T.C., Petropoulos, C.J., Whitcomb, J.M., McHenry, C. and Kuritzkes, D.R. (2001) Inhibition of Purified Recombinant Reverse Transcriptase from Wild-Type and Zidovudine-Resistant Clinical Isolates of Human Immunodeficiency Virus Type 1 by Zidovudine, Stavudine, and Lamivudine Triphosphates.  J. Infect. Dis., 184, 1336-1340.
  • 93)  Song, M-S, Dallmann, H.G. and McHenry, C. (2001) Carboxyl-terminal Domain III of the delta' Subunit of the DNA Polymerase III Holoenzyme Binds delta. J. Biol. Chem., 276, 40668-40679.
  • 92)  Glover, B., Pritchard, A. and McHenry, C. (2001) Tau Binds and Organizes Escherichia coli Replication Proteins through Distinct Domains:  Domain III, shared by gamma and tau, oligomerizes DnaX.   J. Biol. Chem.276, 35842-35846.
  • 91)  Pritchard, A.E. and McHenry, C. (2001)  Assembly of  DNA Polymerase III Holoenzyme:  Co-assembly  of gamma and tau is Inhibited by DnaX Complex Accessory Proteins but Stimulated by DNA polymerase III Core.   J. Biol. Chem., 276, 35217-35222.
  • 90)  Song, M-S, Pham, P., Olson, M., Carter, J., Franden, M., Schaaper, R. and McHenry, C. (2001)  The delta and delta' Subunits of the DNA Polymerase III Holoenzyme Are Essential for Initiation Complex Formation and Processive Elongation.   J. Biol. Chem., 276, 35165-35175.
  • 89)  Glover, B. and McHenry, C. (2001)  The DNA Polymerase III Holoenzyme:  An Asymmetric Dimeric Replicative Complex with Leading and Lagging Strand Polymerases.   Cell, 105, 925–934.
  • 88)  Gao, D. and McHenry, C. (2001) Tau Binds and Organizes Escherichia coli Replication Proteins through Distinct Domains:  Domain III, shared by gamma and tau, Binds delta-delta' and chi-psi.   J. Biol. Chem., 276, 4447-4453.
  • 87)  Gao, D. and McHenry, C. (2001) Tau Binds and Organizes Escherichia coli Replication Proteins through Distinct Domains:  Domain IV, Located within the Unique Carboxyl-terminus of tau, Binds the Replication Fork Helicase, DnaB.   J. Biol. Chem., 276, 4441-4446.
  • 86)  Gao, D. and McHenry, C. (2001) Tau Binds and Organizes E. coli Replication Proteins through Distinct Domains: Partial Proteolysis of Terminally Tagged tau to Determine Candidate Domains and to Assign Domain V as the alpha Binding Domain.   J. Biol. Chem., 276, 4433-4440.
  • 85)  Pritchard, A., Dallmann, G., Glover, B. and McHenry, C. (2000)  A Novel Assembly Mechanism for the DNA Polymerase III Holoenzyme DnaX Complex:  Association of delta-delta' with DnaX4 Forms DnaX3delta-delta'.   EMBO J., 19,  6536-6545.
  • 84)  Dallmann, H.G., Kim, S., Pritchard, A.E., Marians, K.J. and McHenry, C. (2000) Characterization of the Unique C-terminus of the E. coli tau DnaX Protein:  Monomeric C-tau binds alpha and DnaB and can Partially Replace tau in Reconstituted Replication Forks.  J. Biol. Chem., 275, 15512-15519.
  • 83)  Glover, B.P. and McHenry, C. (2000) The DnaX-binding Subunits delta' and psi Are Bound to gamma and Not tau in the DNA Polymerase III Holoenzyme. J. Biol. Chem., 275, 3017-3020.
  • 82)  Pham, P.T., Olson, M.W., McHenry, C. and Schaaper, R.M. (1999) Mismatch Extension by Escherichia coli DNA Polymerase III Holoenzyme.  J. Biol. Chem.,274, 3705-3710.
  • 81)  Pritchard, A.E. and McHenry, C. (1999)  Identification of the Acidic Residues in the Active Site of DNA Polymerase III.  J. Mol. Biol., 285, 1067-1080.
  • 80)  Glover, B.P. and McHenry, C. (1998) The chi-psi Subunits of DNA Polymerase III Holoenzyme Bind to Single-stranded DNA-binding Protein (SSB) and Facilitate Replication of an SSB-coated Template.  J. Biol. Chem.273, 23476-23484.  
  • 79)  Pham, P.T., Olson, M.W., McHenry, C. and Schaaper, R.M. (1998)  The Base Substitution and Frameshift Fidelity of Escherichia coli DNA Polymerase III Holoenzyme in Vitro.  J. Biol. Chem., 273, 23575-23584.
  • 78)  Marians, K.J., Hiasa, H., Kim, D.R. and McHenry, C. (1998) Role of the Core DNA Polymerase III Subunits at the Replication Fork: alpha Is the only Subunit Required for Processive Replication.  J. Biol. Chem., 273, 2452-2457.
  • 77)  Kim, D. R., Pritchard, A.E. and McHenry, C. (1997) Localization of the Active Site of the alpha Subunit of the Escherichia coli DNA Polymerase III Holoenzyme.  J. Bacteriol., 179, 6721-6728
  • 76)  McHenry, C., Seville, M. and Cull, M.G. (1997) A DNA Polymerase III Holoenzyme-like Subassembly from an Extreme Thermophilic Eubacterium.  J. Mol. Biol.272, 178-189.
  • 75)  Burnett, B. and McHenry, C.  (1997) Posttranscriptional Modification of Retroviral Primers is Required for Late Stages of DNA Replication.  Proc. Natl. Acad. Sci., USA 94, 7210-7215.
  • 74)  Seville, M., West, A., Cull, M. and McHenry, C. (1996) Fluorometric Assay for DNA Polymerases and Reverse Transcriptase.  BioTechniques, 21, 664-672
  • 73)  Kim, S., Dallmann, H.G., McHenry, C. and Marians, K.J. (1996) Tau Couples the Leading- and Lagging-strand Polymerases at the Escherichia coli DNA Replication Fork.  J. Biol. Chem., 271, 21406-21412.
  • 72)  Kim, D.R. and McHenry, C. (1996) Identification of the beta-Binding Domain of the alpha Subunit of Escherichia coli Polymerase III Holoenzyme.  J. Biol. Chem., 271, 20699-20704.
  • 71)  Kim, D.R. and McHenry,C. (1996) Biotin Tagging Deletion Analysis of Domain Limits Involved in Protein-Macromolecular Interactions:  Mapping the tau Binding Domain of the DNA Polymerase III alpha Subunit.  J. Biol. Chem., 27120690-20698.
  • 70)  Kim, D.R. and McHenry, C. (1996) In Vivo Assembly of Overproduced DNA Polymerase III:  Overproduction, Purification and Characterization of the alpha, alpha-epsilon and alpha-epsilon-theta Subunits.  J. Biol. Chem., 27120681-20689.
  • 69)  Kim, S., Dallmann, H.G., McHenry, C. and Marians, K. J. (1996) Tau Protects beta in the Leading-strand Polymerase Complex at the Replication Fork.  J. Biol. Chem.271, 4315-4318.
  • 68)  Pritchard, A.E., Dallmann, H.G. and McHenry, C. (1996) In Vivo Assembly of the tau-Complex of the DNA Polymerase III Holoenzyme Expressed from a Five-Gene Artificial Operon:  Cleavage of the tau-complex to Form a Mixed tau-gamma complex by the OmpT Protease.  J. Biol. Chem., 271, 10291-10298
  • 67)  Kim, S., Dallmann, H.G., McHenry, C. and Marians, K.J. (1996) Coupling of a Replicative Polymerase and Helicase:  A tau-DnaB Interaction Mediates Rapid Replication Fork Movement.  Cell, 84, 643-650.
  • 66)  Olson, M., Dallmann, H.G. and McHenry, C. (1995) DnaX-Complex of E. coli DNA Polymerase III Holoenzyme:  The chi-psi Complex Functions by Increasing the Affinity of tau and gamma for delta-delta' to a Physiologically Relevant Range.  J. Biol. Chem., 270, 29570-29577.
  • 65)  Dallmann, H.G. and McHenry, C. (1995) DnaX-Complex of Escherichia coli DNA Polymerase III Holoenzyme:  Physical Characterization of the DnaX Subunits and Complexes.  J. Biol. Chem., 270, 29563-29569.
  • 64)  Dallmann, H.G., Thimmig, R. and McHenry, C. (1995) DnaX-Complex of E. coli DNA Polymerase III Holoenzyme:  Central Role of tau in Initiation Complex Assembly and in Determining the Functional Asymmetry of Holoenzyme.  J. Biol. Chem., 270, 29555-29562.
  • 63)  Cull, M. and McHenry, C. (1995) Purification of E. coli DNA Polymerase III Holoenzyme, in DNA Replication Methods in Enzymology, Vol. 262, Chapter 3 (Campbell, J., volume ed.), pp 22-35, Academic Press, New York.
  • 62)  Reems, J., Wood, S. and McHenry, C. (1995) E. coli DNA Polymerase III Holoenzyme Subunits alpha, beta and gamma Directly Contact the Primer Template.  J. Biol Chem., 270, 5606-5613.
  • 61)  Reems, J. and McHenry, C. (1994) E. coli DNA Polymerase III Holoenzyme Footprints Three Helical Turns of Its Primer.  J. Biol. Chem., 269, 33091-33096.
  • 60)  You, J-C. and McHenry, C. (1994) HIV Nucleocapsid Protein Accelerates Strand Transfer of the Terminally Redundant Sequences Involved in Reverse Transcription.  J. Biol. Chem., 269, 31491-31495.
  • 59)  Hottiger, M., Podust, V., Thimmig, R., McHenry, C. and Hübscher, U. (1994) Strand Displacement Activity of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Heterodimer and Its Individual Subunits.  J. Biol. Chem., 269, 986-991. 
  • 58)  Carter, J., Franden, M., Lippincott, J. and McHenry, C. (1993) Identification, Molecular Cloning and Characterization of the Gene Encoding the chi Subunit of DNA Polymerase III Holoenzyme of Escherichia coli.  Mol. Gen. Genet., 241, 399-408.
  • 57)  Carter, J., Franden, M., Aebersold, R. and McHenry, C. (1993) Identification, Isolation, and Overexpression of the Gene Encoding the psi Subunit of DNA Polymerase III Holoenzyme.  J. Bacteriol., 175, 5604-5610.
  • 56)  Thimmig, R. and McHenry, C. (1993) HIV Reverse Transcriptase:  Expression in E. coli, Purification and Characterization of a Functionally and Structurally Asymmetric Dimeric Polymerase.  J. Biol. Chem., 268, 16528-16536.  
  • 55)  You, J-C. and McHenry, C. (1993) HIV Nucleocapsid Protein: Expression in E. coli, Purification and Characterization.  J. Biol. Chem., 268, 16519-16527.
  • 54)  Carter, J., Franden, M., Aebersold, R., Kim, D-R. and McHenry, C. (1993) Isolation, Sequencing and Overexpression of the Gene Encoding the theta Subunit of DNA Polymerase III Holoenzyme.  Nucleic Acids Res., 21, 3281-3286.
  • 53)  Carter, J., Franden, M., Aebersold, R. and McHenry, C. (1993) Identification, Isolation and Characterization of the Structural Gene Encoding the delta' Subunit of E. coli DNA Polymerase III Holoenzyme.  J. Bacteriol., 175, 3812-3822.
  • 52)  Carter, J., Franden, M., Aebersold, R. and McHenry, C. (1992) Molecular Cloning, Sequencing and Overexpression of the Structural Gene Encoding the delta Subunit of E. coli DNA Polymerase III Holoenzyme.  J. Bacteriol., 174, 7013-7025.
  • 51)  Wu, C.A., Zechner, E.L., Reems, J., McHenry, C., and Marians, K.J. (1992) Coordinated Leading- and Lagging-strand Synthesis at the Escherichia coli DNA Replication Fork: V.  Primase Action Regulates the Cycle of Okazaki Fragment Synthesis.  J. Biol. Chem., 267, 4074-4083.
  • 50)  Wu, C.A., Zechner, E.L., Hughes, A.J.,Jr., Franden, M., McHenry, C. and Marians, K.J.  (1992) Coordinated Leading- and Lagging-strand Synthesis at the Escherichia coli DNA Replication Fork: IV.  Reconstitution of an Asymmetric, Dimeric DNA Polymerase III Holoenzyme.  J. Biol. Chem., 267, 4064-4073.
  • 49)  Griep, M. A. and McHenry, C. (1992) Fluorescence Energy Transfer Between the Primer and the beta Subunit of the DNA Polymerase III Holoenzyme . J. Biol. Chem., 267, 3052-3059.
  • 48)  McHenry, C. (1991) DNA Polymerase III Holoenzyme:  Components, Structure and Mechanism of a True Replicative Complex.  J. Biol. Chem., 266, 19127-19130.
  • 47)  McHenry, C. (1992) DNA Replication (invited article) in Emerging Targets for Antibacterial and Antifungal Chemotherapy, (J. Sutcliffe and N. Georgopapadakou, eds.), pp. 37-67, Chapman & Hall, New York.
  • 46)  Flower, A. and McHenry, C., (1991) Transcriptional Organization of the Escherichia coli dnaX Gene. J. Mol. Biol., 220, 649-658.
  • 45)  Hughes, A., Bryan, S., Chen, H. Moses, R. and McHenry, C.  (1991)  Escherichia coli DNA Polymerase II is Stimulated by DNA Polymerase III Holoenzyme Auxiliary Subunits.  J. Biol. Chem.266, 4568-4573.
  • 44)  Reems, J., Griep, M. and McHenry, C. (1991)  The Proofreading Activity of DNA Polymerase III Responds Like Elongation Activity to Auxiliary Subunits.  J. Biol. Chem.266, 4878-4882.
  • 43)  Griep, M. and McHenry, C. (1990)  Dissociation of the DNA Polymerase III Holoenzyme beta2 Subunits is Accompanied by a Conformational Change at Distal Cysteines 333.  J. Biol. Chem.265, 20356-20363.
  • 42)  Griep, M. Reems, J., Franden, M. and McHenry, C. (1990)  Reduction of the Potent DNA Polymerase III Holoenzyme 3'--> 5' Exonuclease Activity by Template-Primer Analogs.  Biochemistry29, 9006-9014.
  • 41)  Flower, A. and McHenry, C. (1990)  The gamma Subunit of DNA Polymerase III Holoenzyme of Escherichia coli is Produced by Ribosomal Frameshifting. Proc. Natl. Acad. Sci. U.S.A., 87, 3713-3717.
  • 40)  McHenry, C., Griep, M. Tomasiewicz, H. and Bradley, M. (1989) Functions and Regulation of DNA Polymerase III Holoenzyme, An Asymmetric Dimeric DNA Polymerase, in Molecular Mechanisms in DNA Replication and Recombination (C. Richardson and I.R. Lehman, eds.), pp. 115-126, Alan R. Liss, Inc., New York.
  • 39)  Griep, M. and McHenry, C. (1989) Glutamate Overcomes the Salt Inhibition of DNA Polymerase III Holoenzyme.  J. Biol. Chem.264, 11294-11301.
  • 38)  Cull, M. and McHenry, C. (1990) Preparation of Extracts from Prokaryotes in Guide to Protein Purification, in Methods in Enzymology182, Chapter 12 (volume Deutscher, M., ed.), pp. 147-154, Academic Press, New York.  
  • 37)  McHenry, C. (1988)  The Asymmetric Dimeric Polymerase Hypothesis:  A Progress Report.   Biochem. Biophys. Acta (invited review), 951, 240-248.
  • 36)  McHenry, C. (1989)  Replication of the Human Immunodeficiency Virus in Molecular Biology of Chromosome Function (K. Adolph, ed.), Ch. 5, pp. 97-129, Springer-Verlag, New York.
  • 35)  Franden, M. and McHenry, C. (1988)  Detection of an Epitope, Not Required for Polymerization, That is Conserved between E. coli DNA Polymerases I and III and Bacteriophage T4 DNA Polymerase. Nucleic Acids Res., 16, 6353-6360.  
  • 34)  Griep M. and McHenry, C. (1988) The Dimer of the beta Subunit of Escherichia coli DNA polymerase III Holoenzyme is Dissociated into Monomers upon Binding Magnesium(II).  Biochemistry27, 5210-5215.
  • 33)  McHenry, C., Tomasiewicz, H., Griep, M., Fürste, P. and Flower, A. (1988)  DNA Polymerase III Holoenzyme:  Mechanism and Regulation of a True Replicative Complex in DNA Replication and Mutagenesis (Moses, R and Summers, W., eds.), pp. 14-26, American Society for Microbiology, Washington, D.C.
  • 32)  McHenry, C. (1988) DNA Polymerase III Holoenzyme of Escherichia coli.  Ann. Rev. Biochem., 57, 519- 550.
  • 31)  Santi, D., McHenry, C., Raines, R. and Ivanetich, K. (1987) Kinetics and Thermodynamics of the Interaction of 5-Fluoro-2'-Deoxyuridylate with Thymidylate Synthase.  Biochemistry26, 8606-8613.
  • 30)  McHenry, C., Flower, A.M. and Hawker, J.R. (1988) Coordination of Leading with Lagging Strand Synthesis by the Asymmetric Dimeric DNA Polymerase III Holoenzyme of E. coli, in Cancer Cells 6: Eukaryotic DNA Replication (Kelly, T. and Stillman, B., eds.), pp. 35-41, Cold Spring Harbor, New York.
  • 29)  Hawker, J.R. and McHenry, C. (1987)  Monoclonal Antibodies Specific for the tau Subunit of the DNA Polymerase III Holoenzyme of Escherichia coli:  Use to Demonstrate that tau is the Product of the dnaZX Gene and that both it and gamma, the dnaZ Gene Product, are Integral Components of the Same Enzyme Assembly.  J. Biol. Chem.262, 12722-12727.
  • 28)  Tomasiewicz, H. and McHenry, C. (1987)  Sequence Analysis of the Escherichia coli dnaE Gene.  J. Bacteriol.169, 5735-5744.
  • 27)  Oberfelder, R. and McHenry, C. (1987) Characterization of 2’ (3’)-Trinitrophenyl-ATP as an Inhibitor of ATP-dependent Initiation Complex Formation between the DNA Polymerase III Holoenzyme and Primed DNA.  J. Biol. Chem.262, 4190-4194.
  • 26)  Flower, A. and McHenry, C. (1986)  The Adjacent dnaZ and dnaX Genes of Escherichia coli are Contained within One Continuous Open Reading Frame. Nucleic Acids Res., 148091-8101.
  • 25)  Kwon-Shin, O., Bodner, J., McHenry, C. and Bambara, R. (1987)  Properties of Initiation Complexes Formed between Escherichia coli DNA Polymerase III Holoenzyme and Primed DNA in the Absence of ATP.  J. Biol. Chem.2622121-2130.
  • 24)  McHenry, C., Oberfelder, R., Johanson, K., Tomasiewicz, H. and Franden, M. (1987)  Structure and Mechanism of the DNA Polymerase III Holoenzyme, in DNA Replication and Recombination (Kelly, T. and McMacken, R., eds.),  pp 47-61, Alan R. Liss, Inc., New York.
  • 23)  Johanson, K., Haynes, T. and McHenry, C. (1986)  Chemical Characterization and Purification of the beta Subunit of the DNA Polymerase III Holoenzyme from an Overproducing Strain.   J. Biol. Chem.,261, 11460-11465.
  • 22)  LaDuca, R., Crute, J., McHenry, C. and Bambara, R. (1986)  The beta Subunit of the Escherichia coli DNA Polymerase III Holoenzyme Interacts Functionally with the Catalytic Core in the Absence of other Subunits.   J. Biol. Chem., 261, 7550-7557.
  • 21)  McHenry, C. (1985) DNA Polymerase III Holoenzyme of Escherichia coli: Components and Function of a True Replicative Complex. (invited review).  Mol. Cell. Biochem., 66, 71-85.
  • 20)  Wu, Y.H., Franden, M., Hawker, J.R. and McHenry, C. (1984) Monoclonal Antibodies Specific for the alpha Subunit of the Escherichia coli DNA Polymerase III Holoenzyme.   J. Biol. Chem., 259, 12117-12122.
  • 19)  Shepard, D., Oberfelder, R. Welch, M. and McHenry, C. (1984) Determination of the Precise Location and Orientation of the Escherichia coli dnaE Gene.   J. Bacteriol., 158, 455-459.
  • 18)  McHenry, C. and Johanson, K. (1984) DNA Polymerase III Holoenzyme of Escherichia coli:  An Asymmetric Dimeric Replicative Complex Containing Distinguishable Leading and Lagging Strand Polymerases in Proteins Involved in DNA Replication, (Hübscher, U., and Spadari, S., eds.), pp 315-319, Plenum Press.
  • 17)  Johanson, K. and McHenry, C. (1984) Adenosine 5'-0-(3-thiotriphosphate) Can Support the Formation of an Initiation Complex between the DNA Polymerase III Holoenzyme and Primed DNA.  J. Biol. Chem., 259, 4589-4595.
  • 16)  La Duca, R., Fay, P., Chuang, C., McHenry, C. and Bambara, R. (1983) Site-Specific Pausing of DNA Synthesis Catalyzed by Four Forms of Escherichia coli DNA Polymerase III.  Biochemistry, 22, 5177-5188.
  • 15)  Crute, J., La Duca, R., Johanson, K., McHenry, C. and Bambara, R. (1983) Excess beta Subunit Can Bypass the ATP Requirement for Highly Processive Synthesis by the Escherichia coli DNA Polymerase III Holoenzyme.  J. Biol. Chem., 258, 11344-11349.
  • 14)  Welch, M. and McHenry, C. (1982) Cloning and Identification of the Product of the dnaE Gene of Escherichia coli.  J. Bacteriol., 152, 351-356.  
  • 13)  Johanson, K. and McHenry, C. (1982) The beta Subunit of the DNA Polymerase III Holoenzyme Becomes Inaccessible to Antibody after Formation of an Initiation Complex with Primed DNA.   J. Biol. Chem., 257, 12310-12315.
  • 12)  Fay, P., Johanson, K., McHenry, C. and Bambara, R. (1982) Size Classes of Products Synthesized Processively by Two Subassemblies of Escherichia coliDNA Polymerase III Holoenzyme.   J. Biol. Chem., 257, 5692-5699.
  • 11)  McHenry, C. (1982) Purification and Characterization of Escherichia coli DNA Polymerase III': Identification of tau as a Subunit of the DNA Polymerase III Holoenzyme.   J. Biol. Chem., 257, 2657-2663
  • 10)  Johanson, K. and McHenry, C (1981) Role of the beta Subunit of the Escherichia coli DNA Polymerase III Holoenzyme in the Initiation of DNA Elongation in Structure and DNA - Protein Interactions of Replication Origins (D. Ray, ed.), pp. 425-436, Academic Press, New York.
  • 9)   McHenry, C. and Kornberg, A. (1981) DNA Polymerase III Holoenzyme, in The EnzymesNucleic Acids, Vol. 14, Pt. A, Ch. 3 (P. Boyer, ed.), pp. 39-50, Academic Press, New York.
  • 8)   McHenry, C. (1980) Multiple Forms of DNA Polymerase III of Escherichia coli in:  Mechanistic Studies of DNA Replication and Genetic Recombination (B. Alberts, ed.), pp. 569-577, Academic Press, New York.
  • 7)   Fay, P. Johanson, K., McHenry, C. and Bambara, R. (1981) Size Classes of Products Synthesized Processively by DNA Polymerase III and DNA Polymerase III Holoenzyme of Escherichia coli.   J. Biol. Chem., 256, 976-983.
  • 6)   Johanson, K. and McHenry, C. (1980) Purification and Characterization of the beta subunit of the DNA Polymerase III Holoenzyme of Escherichia coli.  J. Biol. Chem., 255, 10984-10990.
  • 5)   McHenry, C. and Crow, W. (1979) DNA Polymerase III Escherichia coli: Purification and Identification of Subunits.   J. Biol. Chem., 254, 1748-1753.
  • 4)   McHenry, C. and Kornberg, A. (1977) DNA Polymerase III Holoenzyme of Escherichia coli:  Purification and Resolution into Subunits.   J. BiolChem., 252, 6478-6484 and correction of publishers inversion, left to right, of figure 3, vol 253, p 645.
  • 3)   Santi, D., McHenry, C. and Sommer, H. (1974) Mechanism of Interaction of Thymidylate Synthetase with 5-Fluorodeoxyuridylate.   Biochemistry, 13, 471-481.
  • 2)   Santi, D., McHenry, C. and Perriard, E. (1974) A Filter Assay for Thymidylate Synthetase Using 5-Fluoro-2'-deoxyuridylate as an Active Site Titrant.  Biochemistry, 13, 467-470.  
  • 1)   Santi, D. and McHenry, C. (1972) 5-Fluorodeoxyuridylate:  Covalent Complex with Thymidylate Synthetase.   Proc. Nat. Acad. Sci., 69, 1855-1857.