About
I am a first-year APPM graduate student currently working with David Bortz on methods for analyzing trajectories of single molecules. I received a B.S. in Mathematical Biology from the University of Pittsburgh in 2015. In my spare time I bake bread, play guitar, and climb.
Contact
Email: lewis.r.baker coloradoedu
Research
I am interested in developing methods to estimate chemical observables from experiments and simulations. My current work involves analysis of single molecule trajectories of a class of biomolecules called membrane targeting proteins. These proteins bind to constituent lipids of cell membranes and are involved in numerous biochemical processes, including chemotaxis, collective cell migration, and cell proliferation/growth.
Central to understanding the role of membrane targeting proteins in these processes is the ability to measure the number of high-affinity protein-lipid contacts under a given set of conditions. To this end, I am developing tools to infer details about the binding behavior of proteins based on their movement.
Teaching
Teaching Assistant:
APPM1350, Calculus 1 for Engineers (Fall 2015)
APPM1360, Calculus 2 for Engineers (Spring 2016, Summer 2016)
COEN1360, Calculus 2 Workgroup (Spring 2016)
Publications
Garlena, R.A., Lennox, A.L., Baker, L.R.,, Parsons, T.E., Weinberg, S.M., Stronach, B.E.. Pvr receptor tyrosine kinase promotes tissue closure by coordinating corpse removal and epidermal zippering, Development, 142(19):3403-15, 2015. DOI: 10.1242/dev.122226.