Thumbnail for Lamson et al. 2021

Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors

Nov. 16, 2020

We explore different types of analytic models for crosslinkers and compare them to simulation.

Thumbnail image from Moore et al. 2020

Chiral self-sorting of active semiflexible filaments with intrinsic curvature

May 24, 2020

We present Brownian dynamics simulation results of driven semiflexible filaments with intrinsic curvature and investigate how the interplay between filament rigidity and radius of curvature can tune the self-organization behavior in homochiral systems and heterochiral mixtures.

Thumbnail image from Moore et al. 2020

Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness

Sept. 25, 2019

We use simulations of driven filaments with tunable soft repulsion and rigidity in order to better understand how the interplay between filament flexibility and steric effects can lead to different active steady states.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

Spindle images.

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

Jan. 20, 2017

Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.

Model cartoon

Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture

June 24, 2016

Recent work has found that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic instability and rotational diffusion are not well understood.

Filaments and motor image

Microscopic origins of anisotropic active stress in motor-driven nematic liquid crystals

Nov. 23, 2015

We study a physical model of filaments, crosslinking motors, and static crosslinkers to dissect the microscopic mechanisms of active stress generation in a two-dimensional system of orientationally aligned rods.

Simulation snapshot

Multiscale modeling and simulation of microtubule/motor protein assemblies

Oct. 7, 2015

Microscopic motor activity causes polarity-dependent interactions between motor proteins and microtubules in reconstituted cytoskeletal active matter.

Phase diagram

Hysteresis, reentrance, and glassy dynamics in systems of self-propelled rods

Sept. 30, 2015

Non-equilibrium active matter made up of self-driven particles with short-range repulsive interactions exhibits collective motion and nonequilibrium order-disorder transitions.