Schematic of nuclear pore complex

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

Sept. 15, 2015

We used nuclear magnetic resonance spectroscopy to show that FG repeats are highly dynamic IDPs, stabilized by the cellular environment. Fast transport is supported because the rapid dynamics of transport factor-FG interactions.

Model cartoon

Multiscale polar theory of microtubule and motor-protein assemblies

Jan. 30, 2015

Microtubules and motor proteins can form new “bioactive” liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics.

model cartoon

Regulation of chromosome speeds in mitosis

Sept. 6, 2013

When chromosomes are being separated in preparation for cell division, their motions are slow relative to the speed at which many motor enzymes can move their cellular cargoes and at which microtubules depolymerize.

data plot

Biophysics of filament length regulation by molecular motors

April 16, 2013

Regulating physical size is an essential problem that biological organisms must solve, but it is not well understood what physical principles and mechanisms organisms use to sense and regulate their size.

journal cover

Linear aggregation and liquid-crystalline order: comparison of Monte Carlo simulation and analytic theory

Dec. 31, 2010

Many soft-matter and biophysical systems are composed of monomers that reversibly assemble into rod-like aggregates that can then order into liquid-crystal phases.

model cartoon

Microtubule depolymerization by the kinesin-8 motor Kip3p: a mathematical model

April 30, 2009

Proteins from the kinesin-8 family promote microtubule depolymerization, a process thought to be important for the control of microtubule length in living cells.

model schematic

A two-state model for helicase translocation and unwinding of nucleic acids

Dec. 31, 2008

Helicases are molecular motors that unwind double-stranded nucleic acids. Here we model a helicase motor that can switch between two states, which could represent two different points in the ATP hydrolysis cycle.

network cartoon

Activating and inhibiting connections in biological network dynamics

Dec. 4, 2008

The balance between activating and inhibiting connections is important in determining whether network dynamics reach steady state or oscillate.

experimental schematic

Elasticity of short DNA molecules: theory and experiment for contour lengths of 0.6-7 micrometers

Dec. 31, 2007

The wormlike chain (WLC) model currently provides the best description of double-stranded DNA elasticity for micron-sized molecules.

TFIIA structural model

TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability

Dec. 31, 2007

TFIIA induces a conformational change within the TBP/TATA complex that enhances its stability under both in vitro and physiological salt conditions. We present a refined model for the effect that TFIIA has on DNA conformation that takes into account potential changes in bend angle as well as twist angle.