We used nuclear magnetic resonance spectroscopy to show that FG repeats are highly dynamic IDPs, stabilized by the cellular environment. Fast transport is supported because the rapid dynamics of transport factor-FG interactions.
When chromosomes are being separated in preparation for cell division, their motions are slow relative to the speed at which many motor enzymes can move their cellular cargoes and at which microtubules depolymerize.
Regulating physical size is an essential problem that biological organisms must solve, but it is not well understood what physical principles and mechanisms organisms use to sense and regulate their size.
Helicases are molecular motors that unwind double-stranded nucleic acids. Here we model a helicase motor that can switch between two states, which could represent two different points in the ATP hydrolysis cycle.
TFIIA induces a conformational change within the TBP/TATA complex that enhances its stability under both in vitro and physiological salt conditions. We present a refined model for the effect that TFIIA has on DNA conformation that takes into account potential changes in bend angle as well as twist angle.