Thumbnail of the nuclear pore complex from Maguire et al. 2019

Design principles of selective transport through biopolymer barriers

July 30, 2019

We develop a model motivated by features of the nuclear pore complex (NPC) which provides a framework to control binding-induced selective transport in bipolymeric materials.

Model schematic for sticky and slippery obstacles.

Effects of soft interactions and bound mobility on diffusion in crowded environments: a model of sticky and slippery obstacles

June 12, 2017

There are many biological systems in which tracer particles diffuse in a crowded environment. We implemented a lattice Monte Carlo model to analyze the effects of binding kinetics, bound motion, and obstacle size on tracer diffusive in the presence of soft obstacles.