Thumbnail for Lamson et al. 2021

Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors

Nov. 16, 2020

We explore different types of analytic models for crosslinkers and compare them to simulation.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

Model cartoon

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

May 17, 2017

Pushing forces generated by microtubule polymerization are sufficient to promote spindle pole separation and the assembly of bipolar spindle in the absence of molecular motors.

Spindle images.

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

Jan. 20, 2017

Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.