Thumbnail image from Moore et al. 2019 PRL

Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness

Sept. 25, 2019

Jeffrey M. Moore, Tyler N. Thompson, Matthew A. Glaser, Meredith D. Betterton (2019). arXiv: 1909.11805 . Download In active matter systems, self-propelled particles can self-organize to undergo collective motion, leading to persistent dynamical behavior out of equilibrium. In cells, cytoskeletal filaments and motor proteins exhibit activity and self-organization into complex...

Thumbnail image from Maguire 2019 BPJ submission

Bound-state diffusion due to binding to flexible polymers in a selective biofilter

Aug. 25, 2019

We demonstrate that bound mobility via tethered diffusion can be engineered into a synthetic gel using protein fragments derived from the nuclear pore complex.

Thumbnail image form Kuan 2019 BioRxiv posting

Length regulation of microtubule antiparallel overlaps by molecular motors

Aug. 25, 2019

We develop a theory of steady-state overlap length which depends on the filament plus-end motor concentration, determined by a balance between motor arrival and motor departure in the absence of motor-driven sliding.

Thumbnail of the nuclear pore complex from Maguire et al. 2019

Design principles of selective transport through biopolymer barriers

July 30, 2019

We develop a model motivated by features of the nuclear pore complex (NPC) which provides a framework to control binding-induced selective transport in bipolymeric materials.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

Thumbnail image for Wall and Hough 2018 BiophysJ

In-Cell NMR within Budding Yeast Reveals Cytoplasmic Masking of Hydrophobic Residues of FG Repeats

April 19, 2019

In-cell NMR in S. cerevisiae is a novel way of looking at disordered proteins in a crowded cellular environment. The methodology has been developed here, which could be broadly applicable to other protein systems. In an example, the non-specific interactions of the FG Nup construct, FSFG-K, with the cytoplasm is similar to previously found bacterial interactions using NMR relaxation techniques. This work was recently published in Biophysical Journal.

Ants image

Collective clog control: Optimizing traffic flow in confined biological and robophysical excavation

Aug. 16, 2018

Groups of interacting active particles, insects, or humans can form clusters that hinder the goals of the collective. We find that digging performance can be robustly optimized within the constraints of narrow tunnels by individual idleness and retreating.

Model schematic for sticky and slippery obstacles.

Effects of soft interactions and bound mobility on diffusion in crowded environments: a model of sticky and slippery obstacles

June 12, 2017

There are many biological systems in which tracer particles diffuse in a crowded environment. We implemented a lattice Monte Carlo model to analyze the effects of binding kinetics, bound motion, and obstacle size on tracer diffusive in the presence of soft obstacles.

Model cartoon

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

May 17, 2017

Pushing forces generated by microtubule polymerization are sufficient to promote spindle pole separation and the assembly of bipolar spindle in the absence of molecular motors.

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