Thumbnail image from Moore et al. 2020

Chiral self-sorting of active semiflexible filaments with intrinsic curvature

May 24, 2020

We present Brownian dynamics simulation results of driven semiflexible filaments with intrinsic curvature and investigate how the interplay between filament rigidity and radius of curvature can tune the self-organization behavior in homochiral systems and heterochiral mixtures.

Thumbnail image from Moore et al. 2019 PRL

Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness

Sept. 25, 2019

We use simulations of driven filaments with tunable soft repulsion and rigidity in order to better understand how the interplay between filament flexibility and steric effects can lead to different active steady states.

Thumbnail image from Moore et al. 2019

Driven flexible filament paper posted to arXiv

Sept. 25, 2019

Our paper "Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness" was posted on the arXiv server today.

Thumbnail for chromosome paper biorxiv news article

Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Torque balance thumbnail for ase1 paper

Cross-linker-mediated spindle assembly theory paper published in Biophysical Journal

May 7, 2019

Our paper " Theory of Cytoskeletal Reorganization during Cross-Linker-Mediated Mitotic Spindle Assembly " was published in the May 7, 2019 edition of Biophysical Journal. Our video was highlighted on the front page of the journal's website .

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

Biophysical Journal logo

Spindle assembly theory paper accepted by Biophysical Journal

March 6, 2019

Our paper "Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly" was accepted for publication at Biophysical Journal.

Model overview

Spindle assembly theory paper posted on biorxiv

Sept. 22, 2018

Our paper "Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly" was posted on the biorxiv preprint server today.

Group photograph

Group members hiked and presented at retreat

June 18, 2018

Members of the group went to the mountains for hiking and the group research retreat. We identified a promising location for our new headquarters (see photo).

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