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Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

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Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

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3D electron tomographic and biochemical analysis of ER, Golgi and trans Golgi network membrane systems in stimulated Venus flytrap (Dionaea muscipula) glandular cells

April 19, 2019

Gergely, Z. R., Martinez, D. E., Donohoe, B. S., Mogelsvang, S., Herder, R., & Staehelin, L. A. (2018). Journal of Biological Research-Thessaloniki, 25 (1). doi:10.1186/s40709-018-0086-2 The insect-trapping leaves of Dionaea muscipula provide a model for studying the secretory pathway of an inducible plant secretory system. The leaf glands were induced...

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Zach Gergely received poster award

Jan. 8, 2018

Zach Gergely's poster at the Rocky Mountain Yeast Meeting received a poster award. Congratulations!

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Zach Gergely and Chris Edelmaier presented posters at ASCB-EMBO

Dec. 4, 2017

Two members of the group presented posters at the American Society for Cell Biology/EMBO 2017 meeting. Chris Edelmaier's poster was titled "Minimal ingredients for coupled spindle assembly and chromosome bi-orientation in a computational model of fission yeast mitosis" and Zach Gergely's was "The effects of microtubule length, dynamics and bundling...

Diffusion image.

Kinetochore capture paper highlighted on Biophysical Journal website

Feb. 7, 2017

Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was published in final form today by the Biophysical Journal and highlighted on the Biophysical Journal website.

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Spindle assembly modeling paper published by Science Advances

Jan. 20, 2017

Robert Blackwell's paper "Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast" was published by Science Advances .

Spindle images.

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

Jan. 20, 2017

Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.

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Zach Gergely's paper published by Molecular Biology of the Cell

Nov. 7, 2016

Zachary Gergely's paper "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast" was published in final form by Molecular Biology of the Cell.

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Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture

June 24, 2016

Recent work has found that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic instability and rotational diffusion are not well understood.

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