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Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Simulation snapshot

Crosslinker-mediated spindle assembly paper published by Nature Communications

May 17, 2017

Our collaborative paper with Phong Tran's lab, "Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast," was published by Nature Communications .

Model cartoon

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

May 17, 2017

Pushing forces generated by microtubule polymerization are sufficient to promote spindle pole separation and the assembly of bipolar spindle in the absence of molecular motors.

Robert Blackwell

Robert Blackwell awarded Humboldt fellowship

March 14, 2017

Alum Robert Blackwell has received a Humboldt Research Fellowship for his postdoctoral work in Germany.

Diffusion image.

Kinetochore capture paper highlighted on Biophysical Journal website

Feb. 7, 2017

Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was published in final form today by the Biophysical Journal and highlighted on the Biophysical Journal website.

Photo of Robert Blackwell

Robert Blackwell awarded APS biological physics thesis research prize

Jan. 23, 2017

Robert Blackwell has been awarded the 2016 Award for Outstanding Doctoral Thesis Research in Biological Physics by the American Physical Society.

Spindle images

Spindle assembly modeling paper published by Science Advances

Jan. 20, 2017

Robert Blackwell's paper "Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast" was published by Science Advances .

Spindle images.

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

Jan. 20, 2017

Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.

Model cartoon

Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture

June 24, 2016

Recent work has found that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic instability and rotational diffusion are not well understood.

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