Our paper " Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling " was published in the Feb 13, 2020 edition of eLife today.
We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.
Two members of the group presented posters at the American Society for Cell Biology/EMBO 2017 meeting. Chris Edelmaier's poster was titled "Minimal ingredients for coupled spindle assembly and chromosome bi-orientation in a computational model of fission yeast mitosis" and Zach Gergely's was "The effects of microtubule length, dynamics and bundling...
Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was published in final form today by the Biophysical Journal and highlighted on the Biophysical Journal website.
Robert Blackwell's paper "Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast" was published by Science Advances .
Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.
Zachary Gergely's paper "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast" was published in final form by Molecular Biology of the Cell.
Recent work has found that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic instability and rotational diffusion are not well understood.
