Vaginal Absorption of Chemicals

Study Goals

The objective of this study is to review available scientific literature to determine if surfactants and other chemicals administered intravaginally can be absorbed systematically or negatively impact vaginal cells or tissues.

Study Impact

 Vaginally used products can contain toxic chemicals such as per- and polyfluoroalkyl substances, surfactants, metals, and others. Chronic dermal exposure to such chemicals can lead to adverse health effects, however the effects of vaginal exposure are unknown. This review will support future research that aims to evaluate absorption and impact of toxic chemicals from commonly used vaginal products, such as menstrual products, lubricants, spermicides, and others. 

Related Publications

HV Thumu, JA Shearston. Vaginal absorption of surfactants and chemicals: a narrative review. International Society for Environmental Epidemiology and International Society of Exposure Science Joint Conference, Atlanta, GA, USA. August 17-20, 2025. Conference abstract and poster.