mcintosh
Recent work has shown that the C-terminal tail is particularly important to kinesin-5 motor function and mitotic spindle assembly. We characterized a series of kinesin-5/Cut7 tail truncation alleles in fission yeast. Our observations suggest that the C-terminal tail of Cut7p contributes to both sliding force and midzone localization.
Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was published in the Feb 13, 2020 edition of eLife today.
Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.
We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.
Members of the group went to the mountains for hiking and the group research retreat. We identified a promising location for our new headquarters (see photo).
Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was published in final form today by the Biophysical Journal and highlighted on the Biophysical Journal website.
Robert Blackwell's paper "Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast" was published by Science Advances.
Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.
Zachary Gergely's paper "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast" was published in final form by Molecular Biology of the Cell.
Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was posted on the arXiv preprint server today.