zhou

We collaborated with the Detweiler lab to apply image quantification tools to their study of novel potential antibiotic compounds.

Recent work has shown that the C-terminal tail is particularly important to kinesin-5 motor function and mitotic spindle assembly. We characterized a series of kinesin-5/Cut7 tail truncation alleles in fission yeast. Our observations suggest that the C-terminal tail of Cut7p contributes to both sliding force and midzone localization.