Thumbnail image form Kuan 2019 BioRxiv posting

Length regulation of microtubule antiparallel overlaps by molecular motors

Aug. 25, 2019

We develop a theory of steady-state overlap length which depends on the filament plus-end motor concentration, determined by a balance between motor arrival and motor departure in the absence of motor-driven sliding.

Hui-Shun Kuan photo

Hui-Shun Kuan's paper published in Science, covered by New York Times

Aug. 16, 2018

Hui-Shun Kuan's paper with Daniel Goldman's group at Georgia Tech on traffic jam avoidance in fire ant tunnel digging has been published in Science and covered in the New York Times , Washington Post , Houston Chronicle , SF Gate , Scientific American , Science News , Ars Technica , BBC , Cosmos , Discover , Popular Mechanics , and Quartz .

Ants image

Collective clog control: Optimizing traffic flow in confined biological and robophysical excavation

Aug. 16, 2018

Groups of interacting active particles, insects, or humans can form clusters that hinder the goals of the collective. We find that digging performance can be robustly optimized within the constraints of narrow tunnels by individual idleness and retreating.

Phase diagram

Phase-plane analysis of the totally asymmetric simple exclusion process with binding kinetics and switching between antiparallel lanes

April 3, 2016

Inspired by experiments on the motion of kinesin-4 motors on antiparallel microtubule overlaps, we analyze a model incorporating the TASEP on two antiparallel lanes with binding kinetics and lane switching.

Model cartoon

Motor protein accumulation on antiparallel microtubule overlaps

Sept. 24, 2015

Biopolymers serve as one-dimensional tracks on which motor proteins move. These phenomena have inspired theoretical models of one-dimensional transport, crowding, and jamming.

model cartoon

Regulation of chromosome speeds in mitosis

Sept. 6, 2013

When chromosomes are being separated in preparation for cell division, their motions are slow relative to the speed at which many motor enzymes can move their cellular cargoes and at which microtubules depolymerize.

data plot

Biophysics of filament length regulation by molecular motors

April 16, 2013

Regulating physical size is an essential problem that biological organisms must solve, but it is not well understood what physical principles and mechanisms organisms use to sense and regulate their size.

model cartoon

Microtubule depolymerization by the kinesin-8 motor Kip3p: a mathematical model

April 30, 2009

Proteins from the kinesin-8 family promote microtubule depolymerization, a process thought to be important for the control of microtubule length in living cells.

model schematic

A two-state model for helicase translocation and unwinding of nucleic acids

Dec. 31, 2008

Helicases are molecular motors that unwind double-stranded nucleic acids. Here we model a helicase motor that can switch between two states, which could represent two different points in the ATP hydrolysis cycle.

Model cartoon

Opening of nucleic-acid double strands by helicases: Active versus passive opening

Jan. 19, 2005

his paper presents a theoretical study of the coupling between helicase translocation and nucleic acid unwinding.