Neurophysiology of Movement Laboratory

Carlson 202G

Department of Integrative Physiology
University of Colorado
Boulder, CO 80309-0354
phone: 303-492-4965
fax: 303-492-6778

Research Interests

The neuromuscular mechanisms that mediate the acute adjustments and chronic adaptations experienced by humans in response to physical activity. Current projects address three main topics:
  1. Aging - adaptations in neuromuscular properties with advancing age: (a) association between indices of health status and neuromuscular performance in healthy older adults; (b) PET-based imaging of glucose uptake by muscle during fatiguing contractions; (c) modulation of spinal reflex pathways during the performance of steady contractions.

  2. Handedness - control strategies used by left-handed individuals as indicated by motor unit recordings.

  3. Multiple sclerosis - the associations between MRI-based estimates of brain structure and function with the fatigue reported by individuals with multiple sclerosis.

Personnel

Opportunities for Undergraduates

  • The requirements for undergraduate students who want a research experience in our Laboratory are:
    • A major in integrative physiology

    • Either have completed or be concurrently enrolled in IPHY 4720 (Neurophysiology)

    • Obtain UROP funding or enroll in independent study (IPHY 4860) for 8-10 hours/week for at least one semester.

  • For more information, contact Diba Mani at (dibamani8@gmail.com)

Videos

Recent Publications

  • Gordon NM, Rudroff T, Enoka JA, Enoka RM. Handedness but not dominance influences variability in endurance time for sustained, submaximal contractions. Journal of Neurophysiology 1008: 1501-1510, 2012.

  • Jordan K, Jesunathadas M, Sarchet DM, Enoka RM. Long-range correlations in motor unit discharge times at low forces are modulated by visual gain and age. Experimental Physiology 98: 546-555, 2013.

  • Pascoe MA, Gould JR, Enoka RM. Motor unit activity at recruitment when young and old adults support compliant loads. Journal of Neurophysiology 109: 1055-1064, 2013.

  • Rudroff T, Kalliokoski KK, Block DE, Gould JR, Klingensmith WC III, Enoka RM. PET/CT imaging of age- and task-associated differences in muscle activity during fatiguing contractions. Journal of Applied Physiology 114: 1211-1219, 2013.