Integrative Physiology of Aging Laboratory
The research goals of the Integrative Physiology of Aging Laboratory are to determine:
- important changes in physiological function with aging;
- modulation of those changes by biological factors (e.g., adiposity, vitamin D/estrogen status) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
- the efficacy of interventions, both lifestyle and pharmacological (including "nutraceuticals"), for reversing adverse changes in physiological function with aging;
- the integrative (systemic to molecular) biological mechanisms that mediate physiological changes with aging and the effects of modulating influences and interventions on those changes.
Within this context of the integrative physiology of aging, a primary focus is "vascular aging", in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A recently added direction of interest involves assessing decreases in motor and cognitive function with aging and the ability of potential anti-aging interventions to improve age-associated reductions in motor/cognitive performance.
A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, and cell culture using cross-sectional, intervention, and longitudinal study designs. Emphasis is placed on the integrative nature of the physiological and pathophysiological processes involved from a mechanistic perspective.
Our research on human subjects is performed in the University of Colorado at Boulder Clinical Translational Research Center (CTRC). If you are interested in participating, please review the Volunteers Needed page and contact one of the investigators.
The laboratory provides scientific training from the undergraduate to postdoctoral levels, and is supported by individual investigator (R01 and R37), fellowship (F31, F32, K01) and institutional training grant (T32) awards from the National Institutes of Health.
See our Facebook page to learn more about activities in our laboratory.
Opportunities for Undergraduates
To learn more about
research opportunities for undergraduates in our laboratory, see the undergraduate research application page
. Our needs change each semester so if we are not currently bringing in new undergrads, please check back.
- Senior Professor: Douglas
R. Seals, Ph.D.
- Postdoctoral Fellows: Dov Ballak, Ph.D., Jamie Justice, Ph.D., Tom LaRocca, Ph.D., Chris Martens, Ph.D.
- Doctoral Students: Rachel Gioscia-Ryan, M.S., Cody Johnson, M.S., Rachelle Kaplon, M.S., Jessica Santos-Parker, M.S.
- Masters Students: Lauren Cuevas, B.S., Blair Denman, B.A., Natalie de Picciotto, B.A., Sierra Hill, B.S., Kara Lubieniecki, B.S., Molly McNamara, M.S., Jamie Richey, B.A.
- Concurrent BA/MS Program: Talia Strahler.
- Undergraduate Students: Hannah Beck, Nina Bispham, Chase Daugherty, Victoria Vorwald.
- Staff Research Assistants: Candace Bassett, B.A., Jonathan Herrera, M.S., Laura Stauber, B.A., Cindy Seals, B.A., Melanie Zigler, M.S.
- Collaborators: Chris Gentile, Ph.D., and Mike Pagliassotti, Ph.D., Colorado State University; Wendy Kohrt, Ph.D., Robert Schwartz, M.D., Kerrie
Moreau, Ph.D., Kristen Jablonski, Ph.D. and Michel Chonchol, M.D., UC-Denver Anschutz Medical Campus; Nichole Reisdorph, Ph.D., National Jewish Health, Denver; and Simon Melov, Ph.D., Buck Institute for Research on Aging, Novato, CA.
Back row: Melanie Zigler, Chase Daugherty, Hannah Beck, Nina Bispham
Third row: Kara Lubieniecki, Jamie Richey, Natalie de Picciotto, Blair Denman, Sierra Hill, Molly McNamara, Talia Strahler, Lauren Cuevas
Second row: Candace Bassett, Cody Johnson, Jessica Santos-Parker, Rachelle Kaplon, Rachel Gioscia-Ryan
Front row: Jonathan Herrera, Doug Seals, Chris Martens, Jamie Justice, Laura Stauber