Convergent Total Synthesis of Potent Thiopeptide Antibiotics; Lactocillin, Micrococcin P1, and Thiocillin
- Student Recipient: Wyatt Powell, Chemistry / Biochemistry
- Faculty Mentor: Maciej Walczak
- Grant Information: 2017 Summer, Individual Grant
- Project Description: This project objective is to develop a convergent synthetic strategy for preparing three naturally occurring thiopeptide antibiotics; lactocillin, micrococcin p1, and thiocillin. This research objective contributes to a larger project that aims to develop new antibiotics by studying the biology of the three targets, so additional therapeutically useful analogues can be generated using the convergent synthetic strategy. This proposed project is responding to an increasing need for investigation of new antibiotics as antibiotic-resistant bacteria are rapidly emerging, threatening millions of people worldwide.