Thumbnail for chromosome paper biorxiv news article

Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Group photograph

Group members hiked and presented at retreat

June 18, 2018

Members of the group went to the mountains for hiking and the group research retreat. We identified a promising location for our new headquarters (see photo).

Diffusion image.

Kinetochore capture paper highlighted on Biophysical Journal website

Feb. 7, 2017

Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was published in final form today by the Biophysical Journal and highlighted on the Biophysical Journal website.

Spindle images

Spindle assembly modeling paper published by Science Advances

Jan. 20, 2017

Robert Blackwell's paper "Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast" was published by Science Advances .

Spindle images.

Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast

Jan. 20, 2017

Microtubules, motors, and cross-linkers are important for bipolarity, but the mechanisms necessary and sufficient for spindle assembly remain unknown. We describe a physical model that exhibits de novo bipolar spindle formation.

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Zach Gergely's paper published by Molecular Biology of the Cell

Nov. 7, 2016

Zachary Gergely's paper "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast" was published in final form by Molecular Biology of the Cell.

Model cartoon

Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture

June 24, 2016

Recent work has found that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore capture in fission yeast, but the relative contributions of dynamic instability and rotational diffusion are not well understood.

Cartoon of kinetichore diffusion and capture inside nuclear envelope

Kinetochore capture preprint posted on arXiv

June 24, 2016

Our paper "Contributions of microtubule dynamic instability and rotational diffusion to kinetochore capture" was posted on the arXiv preprint server today.

Cell image

Zach Gergely's paper published online by Molecular Biology of the Cell

May 9, 2016

Zachary Gergely's paper "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast" was published online by Molecular Biology of the Cell. .

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