New paper on predicting protein phase separation posted to bioRxiv with new predictor available online

Oct. 14, 2022

Our new paper on predicting protein phase separation, Intrinsically disordered regions that drive phase separation form a robustly distinct protein class , has been posted on bioRxiv. The ParSe v2 predictor is now available here .

Overview of approach, including relationship between polymer scaling exponent and phase separation

Beta turn propensity and a model polymer scaling exponent identify intrinsically disordered phase-separating proteins

Oct. 14, 2022

Paper relating polymer scaling exponent to the propensity for intrinsically disordered proteins to phase separate.

A schematic of the post-translational modifications of tubulin tails.

C-Terminal Tail Polyglycylation and Polyglutamylation Alter Microtubule Mechanical Properties

Oct. 14, 2022

We found that microtubule post-translational modifications affect bending rigidity.

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Bound-state diffusion in biofilters paper accepted to Biophysical Journal

Nov. 14, 2019

Our paper " Bound-state diffusion due to binding to flexible polymers in a selective biofilter " was accepted for publication at Biophysical Journal.

Thumbnail from Maguire et al. 2019 PRE

Nuclear pore complex paper published in PRE

Oct. 30, 2019

Our paper " Design principles of selective transport through biopolymer barriers " was published in the 30 October 2019 edition of PRE today.

APS logo for PRE acceptance of Maguire et al 2019

Nuclear pore complex biofiliter paper accepted to PRE

Sept. 11, 2019

Design principles of selective transport through biopolymer barriers paper has been accepted to Physics Review E .

Thumbnail image from Maguire 2019 BPJ submission

Bound-state diffusion in biofilters paper posted to bioRxiv

Aug. 25, 2019

Our paper "Bound-state diffusion due to binding to flexible polymers in a selective biofilter" was posted on the bioRxiv server.

Thumbnail image from Maguire 2019 BPJ submission

Bound-state diffusion due to binding to flexible polymers in a selective biofilter

Aug. 25, 2019

We demonstrate that bound mobility via tethered diffusion can be engineered into a synthetic gel using protein fragments derived from the nuclear pore complex.

Nuclear core complex thumbnail from Maguire et al. 2019

Nuclear pore complex paper posted to bioRxiv

July 30, 2019

Our paper "Design principles of selective transport through biopolymer barriers" was posted on the BioRxiv server.

Thumbnail of the nuclear pore complex from Maguire et al. 2019

Design principles of selective transport through biopolymer barriers

July 30, 2019

We develop a model motivated by features of the nuclear pore complex (NPC) which provides a framework to control binding-induced selective transport in bipolymeric materials.

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