Dr. Sanders research has significantly impacted our understanding of Neural Disease and Degeneration, particularly with regard to the role of cortical projection neurons in dysfunctional sensorimotor and memory circuits. From her previous work designing signal processing solutions for imaging missile systems, she brings high quality, novel approaches for identifying drivers of neurodegeneration and pathological behavior. Her lab develops and incorporates cutting edge techniques for in vivo imaging, neuromodulation, electrophysiology, and genetic manipulation to accelerate advancements in understanding neural circuit plasticity mechanisms in normal and pathological states.
Sanders, T.H.*, Weiss, J., Hogewood, L., Chen, L., Paton, C., McMahan, R.L. and Sweatt, J.D., 2019. Cognition-Enhancing Vagus Nerve Stimulation Alters the Epigenetic Landscape. Journal of Neuroscience, 39(18), pp.3454-3469.
Poplawski S.G., ..., Sanders T.H., et al., 2020. An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement. Molecular Therapy-Nucleic Acids. 19:1399-412.
Sanders, T.H.*, 2019. Phase discontinuities underlie increased drowsiness and diminished sleep quality in older humans. bioRxiv, p.696658. bioRxiv 696658
Sanders, T.H.*, 2017. Stimulation of cortico-subthalamic projections amplifies resting motor circuit activity and leads to increased locomotion in dopamine-depleted mice. Frontiers in integrative neuroscience, 11, p.24.
Sanders, T.H.* and Jaeger, D., 2016. Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice. Neurobiology of disease, 95, pp.225-237.