MSE Areas: Vascular biomaterials, nanomaterials, biological materials, hierarchical structure, controlled biomolecule release
Dr Tan’s laboratory is mainly interested in the interdisciplinary research at the cross-section of nano-materials and material mechanics with vascular medicine. The main research goal of the lab is to improve fundamental understanding as to how biomaterial properties, ranging from nano-scale molecule signaling and mechanics to macro-scale mechanics, play critical roles in remodeling or regenerating blood vessels through local and global regulation of epigenetic environments. Also, in parallel with improved understanding, new therapeutic approaches for cardiovascular diseases are being developed.
Selected Publications and Accomplishments
GaN Nanowire Functionalized with Atomic Layer Deposition Techniques for Enhanced
Immobilization of Biomolecules, Langmuir, 2010, 26 (23), 18382–18391.
Roles of genipin crosslinking and biomolecule conditioning in collagen-based biopolymer: Potential for vascular media regeneration, Journal of Biomedical Material Research A, 2011, 97A, 16-26.
Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers, Acta
Biomaterialia, 2012, 8(4), 1440-1449.
2010 Quantitative Research Development Career-Transition Award, NIH
2008 DAPRA Young Investigator Award, DARPA