MSE Areas: Biomaterials, tissue engineering, polymer chemistry, photopolymerization, hydrogels
Research in the Bryant laboratory combines scaffold development, bioreactors and animal models to address a number of important questions in mechanobiology and tissue engineering. Our research efforts focus on developing materials to help understand the role of biochemical and biophysical cues involved in homeostasis, regeneration and disease for musculoskeletal tissues (e.g., cartilage, bone, cartilage-bone interface, and tendon). We are also interested in elucidating how the host responds to tissue engineering scaffolds when placed in the body and designing novel strategies to improve healing and enhance tissue regeneration and integration. Lastly our group also investigates strategies to control the local architecture of scaffolds for guided tissue growth for engineering tissues like skeletal and cardiac muscle.
Selected Publications and Accomplishments
H.R.C. Screen, S.R. Byers, A.D. Lynn, V. Nguyen, D. Patel, S.J. Bryant. Characterization of a Novel Fiber Composite Material for Mechanotransduction Research of Fibrous Connective Tissues. Advanced Functional Materials. 20(5): 738-747 (2010).
A.K. Blakney, M.D.Swartzlander, S.J. Bryant. The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels. J Biomed Mater Res Part A: 100A: 1375–1386, (2012). Winner of the Society for Biomaterials Outstanding Student Award: Undergraduate Category.
G.D. Nicodemus and S.J. Bryant, Review: Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Engineering Part B: Review, 14(2): 149-165(2008).
Leverhulme Visiting Professor (2012)
Biotechnology and Bioengineering Daniel I.C. Wang Award (2010)
Provost Faculty Achievement Award, CU Boulder (2010)
NSF Faculty Early CAREER Award (2009)”