A.J. Zaug, C.J. Lim*, C.L. Olson, M.T. Carilli, K.J. Goodrich, D.S. Wuttke*, T.R. Cech*, "CST does not evict elongating telomerase but prevents initiation by ssDNA binding," *co-corresponding authors, Nucleic Acids Research, 2021, gkab942, doi: 10.1093/nar/gkab942

N.R. Lloyd and D.S. Wuttke, “Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro,” PLOS ONE, 2021, 16(2): e0237956, doi: 10.1371/journal.pone.0237956 

C.J. Lim, A.T. Barbour, A.J. Zaug, K.J. Goodrich,  A.E. McKay, D.S. Wuttke*, and T.R. Cech*, “The structure of human CST reveals a decameric assembly bound to telomeric DNA,” *co-corresponding authors, Science, 2020, 368(6495): 1081-1085, doi: 10.1126/science.aaz9649

M.Y. Nakamoto, N.C. Lammer, R.T. Batey,* D.S. Wuttke,* "hnRNP K recognition of the B motif of Xist and other biological RNAs," *co-corresponding authors, Nucleic Acids Research, 2020, gkaa677, doi: 10.1093/nar/gkaa677

A.C. Carter, J. Xu, M.Y. Nakamoto, Y.W. Wei, B.J. Zarnegar, Q. Shi, J.P. Broughton, R.C. Ransom, A. Salhotra, S.D. Nagaraja, R. Li, D.R. Dou, K.E. Yost, S.W. Cho, A. Mistry, M.T. Longaker, P.A. Khavari, R.T. Batey, D.S. Wuttke, H.Y. Chang, "Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation," eLIFE, 2020, 9:e54508, doi: 10.7554/eLife.54508.

Z.E. Holmes, D.J. Hamilton, T. Hwang, N.V. Parsonnet, J.L. Rinn, D.S. Wuttke* and R.T. Batey*, "The Sox2 transcription factor binds RNA," *co-corresponding authors, Nature Communications2020, 11:1805, doi: 10.1038/s41467-020-15571-8

M. Pashini, C.M. Reyes, A.E. Gillespie, E.K. Mandell, K. A. Lewis, L.W. Glustrom, T.O. Sharpee, D. S. Wuttke and V. Lundblad, "Replication fork collapse drives telomere homeostasis in wild type cells,” in revision.

M.Y. Nakamoto*, J. Rudolph*, D.S. Wuttke, and K. Luger, "Nonspecific binding of RNA to PARP1 and PARP2 does not lead to catalytic activation," *co-first authors, Biochemistry2019, 58(51):5107-5111, doi: 10.1021/acs.biochem.9b00986.

N.V. Parsonnet, N.C. Lammer, Z.E. Holmes, R.T. Batey*, and D.S. Wuttke*, "The glucocorticoid receptor DNA-binding domain recognizes RNA hairpin structures with high affinity," *co-corresponding authors, Nucleic Acids Research2019doi: 10.1093/nar/gkz486.

K.A. Lewis, S.E. Altschuler, and D.S. Wuttke, "Measuring low-picomolar apparent binding affinities by minigel electrophoretic mobility shift," Methods Mol Biol., 2019, 1855: 341-354. 

L.W. Glustrom, K. Lyon, M. Paschini, C.M. Reyes, N.V. Parsonnet, T.B. Toro, V. Lundblad, and D. S. Wuttke, “Single stranded telomere binding protein employs a dual rheostat for binding affinity and specificity that drives function," Proc. Natl. Acad. Sci. USA, 2018, 115(41): 10315-10320.

N. R. Lloyd and D. S. Wuttke, “Discrimination against RNA backbones by a ssDNA binding protein," Structure, 2018, 26(5): 722-733.

M. A. McKercher, X. Guan, Z. Tan, and D. S. Wuttke, "Diversity in peptide recognition by the SH2 domain of SH2B1," Proteins 2018, 86(2): 164-176.

R. A. Hom and D. S. Wuttke, “Human CST prefers G-rich but not necessarily telomeric sequences," Biochemsitry 2017, doi: 10.1021/acs.biochem.7b00584.

M. A. McKercher and D. S. Wuttke, “Calorimetric Measurement of SH2 Domain Ligand Affinities,” Methods in Molecular Biology, 2017, 1555, 291-305.

M. A. McKercher and D. S. Wuttke, “NMR Chemical Shift Mapping of SH2 Peptide Interactions,” Methods in Molecular Biology, 2017, 1555, 269-290. 

M. A. McKercher, X. Guan, Z. Tan and D. S. Wuttke, “Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of PLCg1," Biochemistry2017, 2225-2237.

N. R. Lloyd and D. S. Wuttke, “Tying Up the Ends: Plasticity in the Recognition of ssDNA at Telomeres,” Biochemistry, 2016, 55, 5326-40.

A. Pinzaru, R. A. Hom, A. Beal, A. F. Philips, E. Ni, T. Cardozo, N. Nair, J. Choi, D. S. Wuttke, A. Sfeir, and E. L. Denchi, “Telomere replication stress induced by POT1 inactivation is a novel tumor promoting mechanism,” Cell Rep., 2016, 15, 2170-84.

N. R. Lloyd and D. S. Wuttke, Less is more: structures of difficult targets with minimal constraints,” Structure, 2014, 22, 1223-4.

T. H. Dickey and D. S. Wuttke, “The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3’ end availability,” Nucleic Acids Res., 2014, 42, 9656 – 65.

T. Rao, J. W. Lubin, G. S. Armstrong, T. M. Tucey, V. Lundblad, and D. S. Wuttke, “Structure of Est3 reveals a bimodal surface with differential roles in telomere replication,” Proc. Natl. Acad. Sci. USA, 2014, 111, 214-8.

K. A. Lewis, D. A. Pfaff, J. N. Earley, S. E. Altschuler, and D. S. Wuttke, “The Tenacious Recognition of Yeast Telomere Sequence by Cdc13 is Fully Exerted by a Single OB-Fold Domain,” Nucleic Acids Res., 2014, 42, 475-84.

T. H. Dickey, S. E. Altschuler and D. S. Wuttke, “Single-stranded DNA-binding Proteins: Multiple Domains for Multiple Functions,” invited review, Structure, 2013, 21, 1074-84.

S. E. Altschuler, K. A. Lewis, and D. S. Wuttke, “Practical Strategies for the Evaluation of High-Affinity Protein/Nucleic Acid Interactions,” J. Nucleic Acids Investigation, 2013, 4, e3.

J. W. Lubin, T. Rao, E. K. Mandell, D. S. Wuttke and V. Lundblad, “Dissecting Protein Function: An Efficient Protocol for Identifying Separation-of-Function Mutations That Encode Structurally Stable Proteins.Genetics, 2013, 193, 715-25.

T. H. Dickey, M. A. McKercher, and D. S. Wuttke,Nonspecific Recognition Is Achieved in Pot1pC through the Use of Multiple Binding Modes,” Structure, 2013, 21, 121-32.

S. E. Altschuler, J. E. Croy, and D. S. Wuttke, “A Small Molecule Inhibitor of the S. pombe Pot1 binding to telomeric DNA,” Biochemistry, 2012, 51, 7833-45.

K. A. Lewis and D. S. Wuttke, “Telomerase and Telomere-Associated Proteins: Structural insights into mechanism and evolution,” Structure, 2012, 20, 28-39.

L. Jones Braun, A. M. Eldridge, J. Cummisky, K. Arthur, and Deborah S. Wuttke, “The Role of Adjuvant in Mediating Antigen Structure and Stability,J. Pharm. Sci., 2012, 101, 1391-9.

R. M. Mitton-Fry and D. S. Wuttke, “1H, 13C and 15N resonance assignments of the DNA-binding domain of the essential protein Cdc13 complexed with single-stranded telomeric DNA,” J. Biomol. NMR, 2002, 22, 379-380.

S. E. Altschuler, T. H. Dickey, and D. S. Wuttke, “Schizosaccharomyces pombe Protection of Telomeres 1 Utilizes Alternate Binding Modes To Accommodate Different Telomeric SequencesBiochemistry, 2011, 50, 7503-15.

E. K. Mandell, A. D. Gelinas, D. S. Wuttke, V. Lundblad, “Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain,”. Biochemistry, 2011, 50, 6289-91.

J. R. Alford, A. C. Fowler, D. S. Wuttke, B. A. Kerwin, R. F. Latypov, J. F. Carpenter, T. W. Randolph, “Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange.J. Pharm. Sci., 2011, 100, 4215.

J. Lee, E. K. Mandell, T. Rao, D. S. Wuttke and V. Lundblad, “Investigating the role of the Est3 protein in yeast telomere replication,” Nucleic Acids Res., 2010, 38, 2279-2290.

A. D. Gelinas, M. Paschini, F. E. Reyes, A. Héroux, R. T. Batey, V. Lundblad and D. S. Wuttke, “Telomere capping proteins are structurally related to RPA with an additional telomere-specific domainProc. Natl. Acad. Sci. USA, 2009, 106, 19298-19303.

J. E. Croy, S. E. Altschuler, N. E. Grimm, and D. S. Wuttke, “Nonadditivity in the recognition of single-stranded DNA by the Schizosaccharomyces pombe protection of telomeres 1 DNA-binding domain, Pot1-DBD,” Biochemistry, 2009, 48, 6864-6875.

J. E. Croy and D. S. Wuttke, “Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pN,” J. Mol. Biol., 2009, 387, 935-938.

D. C. Zappulla, J. N. Roberts, K. Goodrich, T. R. Cech, and D. S. Wuttke, “Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p,” Nucleic Acid Res., 2009, 37, 354-367.

J. E. Croy, J. L. Fast, N. E. Grimm, and D. S. Wuttke, “Thermodynamic characterization of specific single-stranded telomeric DNA binding to the S. pombe, Protection of telomeres 1 (POT1), protein, Biochemistry, 2008, 47, 4345-4358.

A. E. Eldridge and D. S. Wuttke, “Probing the mechanism of recognition of ssDNA by the Cdc13-DBD,” Nucleic Acid Res., 2008, 36, 1624-33.

D. L. Theobald and D. S. Wuttke, “Accurate structural correlations from maximum likelihood superpositions,” PLOS Comp. Biology, 2008, e43.

J. R. Alford, S. Kwok, J. N. Roberts, D. S. Wuttke, B. S. Kendrick, J. F. Carpenter, T. W. Randolph, “Physical characterization of recombinant human Interleukin-1 receptor antagonist monomer-dimer equilibrium at high protein concentrations,” J. Pharm. Sciences, 2008, 97, 3035-50.

D. M. Strauss and D. S. Wuttke, “Characterization of protein-protein interactions critical for poliovirus replication:  analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase,” J. Virol., 2007, 6369-6378.

D. L. Theobald and D.S. Wuttke, “Empirical Bayes hierarchical models for regularizing maximum likelihood estimation in the matrix Gaussian Procrustes problem,” Proc. Natl. Acad. Sci., 2006, 103, 18521-18527.

J. R. Croy and D. S. Wuttke, “Themes in ssDNA recognition by telomere end-protection proteins,” TIBS, 2006, 31, 516-525.

J. E. Croy, E. R. Podell, and D. S. Wuttke, “A new model for Schizosaccharomyces pombe telomere recognition: The telomeric single-stranded DNA binding activity of Pot11-389”, J. Mol. Biol., 2006, 361, 80-93.

D. L. Theobald and D. S. Wuttke, "THESEUS: Maximum likelihood superpositioning and analysis of macromolecular structures," Bioinformatics, 2006, 22, 2171-2.

A. M. Eldridge, W. A. Halsey, and D. S Wuttke, “Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13,” Biochemistry, 2005, 45, 871-879.

D. L. Theobald and D. S. Wuttke, “Divergent evolution within protein superfolds inferred from profile-based phylogenetics” J. Mol. Biol., 2005, 354, 722-737.

S. A. Jacobs, E. R. Podell, D. S. Wuttke and T. R. Cech, “Soluble domains of telomerase reverse transcriptase identified by high-throughput screening,” Protein Science, 2005, 14, 2051-2058.

D. L. Theobald and D. S. Wuttke, “Prediction of multiple tandem OB-folds in telomere end-binding proteins Pot1 and Cdc13Structure, 2004, 12, 1877-1879.

D. S. Wuttke, “Targeting the End: The Structure of the Ku80 C-Terminal Domain,” Structure, 2004, 12 55-356.

R. M. Mitton-Fry, E. M. Anderson, L. W. Glustrom, D. L. Theobald and D. S. Wuttke, “Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13,” J. Mol. Biol., 2004, 338, 241-255.

D. L. Theobald, R. B Cervantes, V. Lundblad and D. S. Wuttke, “Homology Among Telomeric End-Protection ProteinsStructure, 2003, 11, 1049-1050.

D. M. Strauss, L. W. Glustrom and D. S. Wuttke, “Towards a Further Understanding of the Poliovirus Replication Complex:  The Solution Structure of the Poliovirus 3A Protein,” J. Mol. Biol., 2003, 330, 225-234.

E. M. Anderson and D. S. Wuttke, “Site-Directed Mutagenesis Reveals the Thermodynamic Requirements for Single-Stranded DNA Recognition by The Telomere-Binding Protein Cdc13,” Biochemistry, 2003, 42, 3751-3758.

D. L. Theobald, R. M. Mitton-Fry and D. S. Wuttke, “Nucleic Acid Recognition by OB-Fold Proteins,” Annu. Rev. Biophys. and Biomol. Struct., 2003, 32, 115-33.

D. D. Ojennus, S. E. Lehto and D. S. Wuttke, “Electrostatic Interactions in the Reconstitution of an SH2 Domain from Constituent Peptide Fragments,” Protein Science, 2003, 12, 44–55.

E. M. Anderson, W. A. Halsey and D. S. Wuttke, “Delineation of the High-Affinity Single-Stranded Telomeric DNA-Binding Domain of S. cerevisiae Cdc13,Nucleic Acids Research, 2002, 30, 4305-4313.

R. M. Mitton-Fry, E. M. Anderson, T. R. Hughes, V. Lundlblad and D. S. Wuttke, “Conserved Structure for Single-Stranded Telomeric DNA Recognition,” Science, 2002, 296, 145 - 147.

L. W. Glustrom, R. M. Mitton-Fry and D. S. Wuttke, “Environmental Estrogens and Breast Cancer: The Importance of Hydroxylated Intermediates,” reviewed letter, J. Natl. Cancer Institute, 2002, 94, 68-69.

D. D. Ojennus, M. R. Fleissner and D. S. Wuttke, “Reconstitution of a Native-Like SH2 Domain from Disordered Peptide Fragments Examined by Multidimensional Heteronuclear NMR,” Protein Science, 2001, 10, 2162-2175.

D. D. Ojennus, R. M. Mitton-Fry and D. S. Wuttke, “Induced Alignment and Measurement of Dipolar Couplings in an SH2 Domain Through Direct Binding with Filamentous Phage,J. Biomol. NMR, 1999, 14, 175-179.

M. P. Foster, D. S. Wuttke, K. R. Clemens, W. Jahnke, I. Radhakrishnan, L. Tennant, M. Reymond, J. Chung and P. E. Wright, “Chemical Shift as a Probe of Molecular Interfaces:  NMR Studies of DNA Binding by the Three Amino Terminal Zinc Finger Domains from Transcription Factor IIIA,” J. Biomol. NMR, 1998, 12, 51-71.

D. S. Wuttke, M. P. Foster, D. A. Case, J. M. Gottesfeld and P. E. Wright, “Solution Structure of the First Three Zinc Fingers of TFIIIA Bound to the Cognate DNA Sequence: Determinants of Affinity and Sequence Specificity,J. Mol. Biol., 1997, 273, 183-206.

M. P. Foster, D. S. Wuttke, D. A. Case, J. M. Gottesfeld and P. E. Wright, “Domain Packing and Dynamics in the DNA Complex of the Amino-Terminal Zinc Fingers of Transcription Factor IIIA,” Nature Struct. Biol., 1997, 4, 605-608.

M. J. Bjerrum, D. R. Casimiro, I-J. Chang, A. J. Dibilio, H. B. Gray, M. G. Hill, R. Langen, G. Mines, L. K. Skov, J. R. Winkler and D. S. Wuttke, “Electron Transfer in Ruthenium-Modified Proteins,” J. Bioeng. Biomem., 1995, 3, 295 - 302.

M. Meier, R. van Eldik, I-J. Chang, G. A. Mines, D. S. Wuttke, J. R. Winkler and H. B. Gray, "Pressure Effects on the Rates of Intramolecular Electron Transfer in Ruthenium-Modified Cytochrome c.  Role of the Intervening Medium in Tuning Distant Fe2+:Ru3+ Electronic Couplings,” J. Am. Chem. Soc., 1994, 116, 1577-1578.

D. S. Wuttke, H. B. Gray, S. L. Fisher and B. Imperiali, “Semisynthesis of Bipyridyl-Alanine Cytochrome c Mutants: Novel Proteins with Enhanced Electron-Transfer Properties,J. Am. Chem. Soc., 1993, 115, 8455-8456.

D. S. Wuttke and H. B. Gray, “Protein engineering as a tool for understanding electron transfer,” Curr. Opin. Struct. Biol., 1993, 3, 555-563.

D. S. Wuttke, M. J. Bjerrum, J. R. Winkler and H. B. Gray, “Electron-Tunneling Pathways in Cytochrome c,” Science, 1992, 256, 1007-1009.

D. S. Wuttke, M. J. Bjerrum, I-J. Chang, J. R. Winkler and H. B. Gray, "Electron Tunneling in Ruthenium-Modified Cytochrome c,” Biochimica Biophysica Acta, 1992, 1101, 168-170.