Benjamin Seelbinder
B.S./M.S. Otto Von Guericke Universität Magdeburg
Ph.D. Student

My research focus lies in the subfield of nuclear mechanosensation. The cell nucleus is known to have the special function of containing, maintaining and interpreting the genomic information that forms the bases of every individual. Despite that, it experiences an enormous amount of deformation in everyday tasks, especially in mechanically challenged tissues like the heart, muscles, skin and tendons. It is unclear how the nucleus protects the integrity of the genomic DNA and maintains its highly structured organization that is necessary for proper gene decryption during such events. Even more, the interconnection of the nucleus through the cytoskeleton leads to an elevated strain forwarding and suggests an active role of the nucleus in mechanosensation. Some hypothesis postulate the nucleus as a master-regulator that integrates all mechanical cues and orchestrates a cell response accordingly. To this date, it is unclear if and to what extend the nucleus is involved in mechanosensation and what the underlying mechanisms of sensing and processing mechanical cues are. Solving these questions will open a new perspective on curing disease, engineering tissue replacements and mechanosensation as a whole.