Thumbnail image from Kuan Betterton 2019 BioRxiv posting

Length regulation of microtubule overlaps paper posted to bioRxiv

Aug. 25, 2019

Our paper "Length regulation of microtubule antiparallel overlaps by molecular motors" was posted on the bioRxiv server.

Thumbnail image from Maguire 2019 BPJ submission

Bound-state diffusion due to binding to flexible polymers in a selective biofilter

Aug. 25, 2019

We demonstrate that bound mobility via tethered diffusion can be engineered into a synthetic gel using protein fragments derived from the nuclear pore complex.

Thumbnail image form Kuan 2019 BioRxiv posting

Length regulation of microtubule antiparallel overlaps by molecular motors

Aug. 25, 2019

We develop a theory of steady-state overlap length which depends on the filament plus-end motor concentration, determined by a balance between motor arrival and motor departure in the absence of motor-driven sliding.

Nuclear core complex thumbnail from Maguire et al. 2019

Nuclear pore complex paper posted to bioRxiv

July 30, 2019

Our paper "Design principles of selective transport through biopolymer barriers" was posted on the BioRxiv server.

Thumbnail of the nuclear pore complex from Maguire et al. 2019

Design principles of selective transport through biopolymer barriers

July 30, 2019

We develop a model motivated by features of the nuclear pore complex (NPC) which provides a framework to control binding-induced selective transport in bipolymeric materials.

Thumbnail for chromosome paper biorxiv news article

Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

Torque balance thumbnail for ase1 paper

Cross-linker-mediated spindle assembly theory paper published in Biophysical Journal

May 7, 2019

Our paper " Theory of Cytoskeletal Reorganization during Cross-Linker-Mediated Mitotic Spindle Assembly " was published in the May 7, 2019 edition of Biophysical Journal. Our video was highlighted on the front page of the journal's website .

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

Biophysical Journal logo

Spindle assembly theory paper accepted by Biophysical Journal

March 6, 2019

Our paper "Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly" was accepted for publication at Biophysical Journal.

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