Mini-microscope for deep brain imaging
Electrical, Computer and Energy Engineering
A team of researchers from the University of Colorado Boulder and University of Colorado Anschutz have demonstrated a microscope that fits on the head of a freely behaving mouse and can peer deeply inside the brain.
The microscope, known as the 2P-FCM, uses an electrowetting lens being developed by Bright and Gopinath. The scope is mounted on the head of a freely moving mouse, where a high-powered, fiber optic light can view and control neural activity as it happens. The lens is liquid and can change shape when electricity is applied. The device enables deep brain imaging and better understanding of animal behaviors, such as spatial navigation, sleep and social interactions.