Faculty Advisor: Kent Hutchison
Understanding the etiology and course of alcohol use disorders by combining neuroimaging methods with genetic analyses; DNA methylation in response to long term alcohol use, including the implication of cardiovascular exercise as a protective or reparative factor; neurobiological correlates of craving and response inhibition, and the relationship between incubation of craving and relapse.
2013-2016 National Science Foundation, Graduate Research Fellowship Program (NSF GRFP)
Beverly Sears Graduate Student Grant Award, 2016
HC Karoly, SL Hagerty, BJ Weiland, KE Hutchison (2015). Advancing Addiction Research through the Integration of Genetics and Neuroimaging. The Wiley Handbook on the Cognitive Neuroscience of Addiction, 407.
Gardiner, C. K., Karoly, H. C., & Bryan, A. D. (2016). Commentary: Differential associations between obesity and behavioral measures of impulsivity. Frontiers in Psychology, 7, 949. http://dx.doi.org/10.3389/fpsyg.2016.00949
Karoly HC, YorkWilliams SL, & Hutchison, KE (2015). Clinical Neuroscience of Addiction: Similarities and Differences Between Alcohol and Other Drugs. Alcoholism Clinical and Experimental Research 39 (11), 2073-2084.
Karoly HC, Bryan AD, Weiland BJ, Mayer A, Dodd A & Feldstein Ewing SW (2015). Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents. Developmental Cognitive Neuroscience, 16, 5-15.
Karoly HC, Callahan T, Schmiege SJ, & Feldstein Ewing SW (2015). Evaluating the Hispanic Paradox in the Context of Adolescent Risky Sexual Behavior: The Role of Parent Monitoring. Journal of Pediatric Psychology: jsv039.
Littlewood, R.A., Claus, E.D., Arenella P., Bogenschutz, M., Karoly H., Feldstein Ewing, S.F., & Hutchison K.E (2014). Dose specific effects of olanzapine in the treatment of alcohol dependence. Psychopharmacology, 1-8.
Karoly HC, Hagerty, SL, & Hutchison, KE (2014). Developing Neurobiological Endophenotypes that Reflect Failure to Control Alcohol Consumption and Dependence. Current Addiction Reports, 1(1), 10-18.
Karoly, H. C., Weiland, B. J., Sabbineni, A., & Hutchison, K. E. (2014). Preliminary functional MRI results from a combined stop-signal alcohol-cue task. J Stud Alcohol Drugs, 75(4), 664-673.
Feldstein Ewing, S. W., Karoly, H., & Hutchison, K. E. (2014). Commentary on Culverhouse et al. (2014): How genomics can bring us towards health equity. Addiction, 109(5), 823-824.
Harlaar, N, Bryan, AD, Thayer, RE, Karoly, HC, Oien, N., & Hutchison, KE. (2013). Methylation of a CpG Site Near the ALDH1A2 Gene is Associated with Loss of Control Over Drinking and Related Phenotypes. Alcoholism: Clinical and Experimental Research.
Karoly, HC, Harlaar, N, & Hutchison, KE. (2013). Substance use disorders: a theory‐driven approach to the integration of genetics and neuroimaging. Annals of the New York Academy of Sciences, 1282(1), 71-91.
Karoly, HC, Stevens, CJ, Thayer, RE, Magnan, RE, Bryan, AD, & Hutchison, KE. (2013). Aerobic Exercise Moderates the Effect of Heavy Alcohol Consumption on White Matter Damage. Alcoholism: Clinical and Experimental Research, 37(9), 1508-1515.
Karoly, HC, Stevens CJ, Magnan RE, Harlaar, N, Bryan AD, & Hutchison KE (2012), Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session Among Sedentary Adults. Journal of Cancer Epidemiology, 2012: 1-12.
Karoly, HC, & Hutchison KE (2012): Does Stress Contribute to the Incubation of Craving? Biological Psychiatry,71:39.
Karoly H.C., Thayer R.E., Hagerty S.L., & Hutchison K.E. (2016, September). TLR4 methylation moderates the relationship between alcohol use severity and gray matter. Poster presentation at the International Society for Biomedical Research on Alcoholism/European Society for Biomedical Research on Alcoholism World Congress, Berlin, Germany.
Bidwell L.C., *Karoly H.C., Bryan A.D. & Hutchison K.E. (2016, September). DRD2 promoter methylation is associated with D2 receptor isoform expression, D2 c11-raclopride binding in-vivo and functional activation of reward circuits. Poster presentation at the International Society for Biomedical Research on Alcoholism/European Society for Biomedical Research on Alcoholism World Congress, Berlin, Germany.
Gardiner C.K., Thayer R.E., Sabbineni A., Karoly H.C., Gillman A.S., Claus E.W., Hutchison K.E. & Bryan A.D. (2016, September). Neural activity in reward and control regions during intertemporal monetary choices is associated with alcohol use and sexual risk. Poster presentation at the International Society for Biomedical Research on Alcoholism/European Society for Biomedical Research on Alcoholism World Congress, Berlin, Germany.
Stevens C.J., Montanaro E., Gardiner C.K., Karoly H.C., Bryan A.D., & Hutchison K.E. (2016, April). Relationship between smoking urge constructs and cigarette use following varenicline or placebo treatment. Poster presentation at the Society for Behavioral Medicine Conference, Washington DC.
Karoly HC, Bryan AD, Weiland BJ, Mayer A, Dodd A & Feldstein Ewing SW. Examining Incentive Responding in the Nucleus Accumbens in Adolescent Substance Users. Poster presentation at the International Society for Integrative Developmental Cognitive Neuroscience (Flux) Congress in Leiden, Netherlands, September 2015.
Karoly HC, Weiland, BJ, Sabbineni, A & Hutchison, KE. Differential alcohol cue reactivity during stop and go trials in a sample of heavy drinkers. Poster presentation and oral presentation at the Research Society on Alcoholism Meeting, San Antonio, Tx, June 2015
Karoly HC, Bryan AD, Weiland BJ, Mayer A, Dodd A & Feldstein Ewing SW. Nucleus accumbens activation and incentive processing: a comparison across substances of abuse in adolescents. Poster presentation at the Research Society on Alcoholism Meeting, San Antonio, Tx, June, 2015.
Karoly HC, Weiland BJ, Sabbineni A, & Hutchison, KE (2014). Measuring the Relationship Between Aerobic Exercise and Functional Connectivity in Executive Control and Salience Networks Among Heavy Drinkers. Poster presentations at the Research Society on Alcoholism meeting, Bellevue, Washington, June, 2014.
Karoly, HC. Aerobic Exercise is Associated with Functional Connectivity in Executive Control Networks Among Heavy Drinkers. Presentation at the Society for Behavioral Medicine meeting, Philadelphia, PA, April 2014.
Karoly HC, Weiland BJ, Sabbineni A, & Hutchison, KE (2013): Preliminary Functional MRI Results from a Combined Stop-Signal/Alcohol-Cue Exposure Task. Poster presentation at the Organization for Human Brain Mapping meeting, Seattle, Washington, June, 2013.
Karoly HC, Monnig M, Harlaar N, Thayer RE & Hutchison KE (2012) Genetic variation in HTR2A and PTPRB are associated with alcohol dependence and white matter integrity in the posterior thalamic radiata. Poster presentation at the Research Society on Alcoholism, San Francisco, CA.
Karoly HC, Blaine SK, Martinez AJ, and Hutchison KE (2011). CRHR1 SNP (rs242924) predicts affective response to intravenous alcohol infusion. Poster presentation at the Research Society on Alcoholism, Atlanta, GA.
YorkWilliams S, Karoly HC, Jones JD, and Ruscio AM, (2010). The Role of Harm Avoidance in Generalized Anxiety Disorder and Social Anxiety Disorder Comorbidity. Poster presentation at World Congress of Behavioral and Cognitive Therapies conference, Boston, MA.
Karoly HC and Bale TL, (2009). Alterations in 5-HT Pathways in Stress Sensitive Knockout Mice. Poster presentation at University of Pennsylvania Biological Basis of Behavior Department Honors Symposium, Philadelphia, PA.
Karoly HC, (2005). Preferences for Motivational Self-Statements: Effects of Running Distance and Gender. Poster presentation at the American Psychological Society 17th annual convention, Los Angeles, CA.