Ryan Gill
Wilfred and Caroline Slade Endowed Professor

Office: SEEC C379 
Mailbox: 027 UCB


Ph.D., University of Maryland at College Park, 1997-1999
MS, University of Maryland at College Park, 1995-1997
BS, The Johns Hopkins University, 1989-1993


  • 2015 Keynote Address, American Chemical Society Synthetic Biology Track
  • 2015 Keynote Address, Peptalk, Synthetic Biology Track
  • 2012 Research Rockstar, Colorado Cleantech Industry Association
  • 2011 Founder’s Award, Opxbio
  • ​2011 Provost's Faculty Achievement Award
  • 2011 Associate Editor of Biotechnology and Bioengineering
  • 2009 Visiting Professor, École Polytechnique Federal de Lausanne
  • 2008 University of Colorado Faculty Fellowship
  • 2007 DuPont Young Professor Award
  • 2007 Rising Star Award, Big 12 Center for Economic Development, Innovation and Commercialization
  • 2006 Provosts Award for Achievement, University of Colorado at Boulder
  • 2005 Patten Assistant Professor Endowed Chair, University of Colorado
  • 2005 National Science Foundation CAREER Award
  • 2005 National Institutes of Health CAREER (K) Development Award
  • 2004 Subaru Educator Spotlight Award
  • 2003 CU-Boulder, Dept. of Chemical Engineering, Undergraduate Advising Award
  • 2001 Vern Norviel Junior Faculty Award

Selected Publications

  • Warner, J., Reeder, P., Karimpour-Fard, A., Andrews, L., and Gill, R.T. 2010. Rapid profiling of a microbial genome using mixtures of barcoded oligonucleotides. Nature Biotechnology. 28:856-862
  • Singh, A., Fard, A.K., and Gill, R.T. 2010. rpoS and relA mediated DNA repair increases DNA mutation rate in redox-impaired Escherichia coli. Applied and Environmental Microbiology.
  • Prior, J., Lynch, M.D., and Gill, R.T. 2010. Broad-host range vectors for protein expression across Gram-negative hosts. Biotechnology and Bioengineering. In press.
  • Warnecke, T., Lynch, M.D., Karimpour-Fard, A., Lipscomb, M.L., and Gill,, R.T. 2010. Rapid decomposition and re-engineering of a complex phenotype through genomic-scale mapping of fitness altering genes. Metabolic Engineering. Appeared Jan 5, 2010 online.
  • Singh, A., Lynch, M.D, and Gill, R.T. 2009. Genes restoring redox balance in fermentation deficient E. coli. Metabolic Engineering. 11:347-354.
  • Prior, J., Shokati, T., Christians, U., and Gill.R.T.2009. Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac. Applied Microbiology and BIotechnology Appeared on line July 2009.
  • Warner, J., Patnaik, R., and Gill. R.T. 2009. Current genomic approaches in strain engineering. Current Opinion in Microbiology.12:223-230.
  • Mills, T., Sandoval, N. and Gill. R.T. 2009. Lignocellulosic hydrolysate toxicity in Escherichia coli. Biotechnology for Biofuels. 2:26.
  • Struble, J. and Gill, R.T.* 2009. Genome-scale identification of cryptic aminoglycoside resistance genes in Pseudomonas aeruginosa. PLOS-One. Appeared on-line July, 2009.
  • Struble, J., Handke, P., and Gill, R.T.* 2009. Construction of Genomic Libraries. Desk Encyclopedia of Microbiology. Editor: M. Schaechter. 3rd Edition.
  • Karimpour-Fard, A., Leach, S., Gill, R.T., and Hunter, L. 2008. Predicting protein interactions in bacteria: which method is best depends on task. BMC-Bioinformatics. 9:397. (IF=3.5)
  • Lynch, M., Warnecke, T. and Gill, R.T.2007. SCALEs:SCalar Analysis of Library Enrichments. Nature Methods. 4:87-93.

Research Interests

Directed Genome Evolution: New Tools and Applications 
Our research falls within the general fields of metabolic engineering, synthetic biology, directed evolution, and genomics and is targeted primarily towards the development biorefining processes for the sustainable production of fuels, commodity chemicals, and pharmaceuticals. We are generally focused on the development of new i) tools for strain engineering (i.e. genome engineering), ii) methods for efficiently determining the genetic basis of so engineered strains (i.e. functional genomics), and iii) frameworks for rationalizing relationships identified between genome structure and function. Our specific projects include:

• Creation, development, and demonstration of novel genome-engineering tools.
• Metabolic engineering for sustainable and fungible bio-diesel production
• Metabolic engineering for sustainable and fungible bio-gasoline production
• Creation, development, and demonstration of new approaches for antimicrobial discovery
• Genome-engineering to improve cellulosic biofuels production

Our research is supported through a number of sources including current or previous grants from the NSF, NIH, DOE, State of Colorado, University of Colorado, Colorado Center for Biorefining and Biofuels, the Cystic Fibrosis Foundation, Agilent, Shell, Dupont, and Opx Bioproducts.