William Old
Assistant Professor
Molecular Cellular and Developmental Biology

Porter B331


Ph.D., 2000, Department of Chemistry University of Colorado, Boulder


Dr. Old is an Assistant Professor in the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado at Boulder. His long term research goals are focused on understanding the signaling networks that regulate cell growth, communication and migration in multicellular organisms, and how these networks become dysregulated and drive cancer. Specifically, he uses biological mass spectrometry to study complex biological systems, with an emphasis on the role of metabolic and signaling networks in human disease. His lab is developing methods to map and integrate multi-omic datasets to rapidly determine the mechanism by which drugs and genetic perturbations affect cellular behavior. His research is sponsored by the National Cancer Institute and the University of Colorado, Boulder. Dr. Old has recently received a $14.5 million dollar DARPA cooperative agreement to fund SPARTA: Subcellular Pan-Omics for Advanced Rapid Threat Assessment.

Licensing of yeast centrosome duplication requires phosphoregulation of sfi1 
Avena, J. S., Burns, S., Yu, Z., Ebmeier, C. C., Old, W. M., Jaspersen, S. L., and Winey, M. 2014.

Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases 
Marholz, L. J., Chang, L., Old, W. M., and Wang, X. 2014

Profiling Chlamydomonas Metabolism under Dark, Anoxic H-Producing Conditions Using a Combined Proteomic, Transcriptomic, and Metabolomic Approach. J Proteome Res.
3. Subramanian, V., Dubini, A., Astling, D. P., Laurens, L. M., Old, W.M., Grossman, A. R., Posewitz, M. C., and Seibert, M. 2014

Identification of Global Ferredoxin Interaction Networks in Chlamydomonas reinhardtii. 
4. Peden, E.A., Boehm, M., Mulder, D.W., Davis, R., Old, W.M., King, P.W., Ghirardi, M.L., and Dubini, A. 2013.

The Non-Coding B2 RNA Binds to the DNA Cleft and Active-Site Region of RNA Polymerase II.
5. Ponicsan, S. L., Houel, S., Old, W. M., Ahn, N. G., Goodrich, J. A., and Kugel, J. F. 2013.